Could Morphine accelerate prostate cancer progression?

[markrichardson]

Is anyone of the opinion that Morphine can accelerate breast, prostate or other cancer progression? I was looking up wether morphine can activate mast cells and found the following:

“We demonstrate that morphine does not influence cancer initiation, but it stimulates the progression of spontaneously developed breast tumours and shortens the survival of tumour-bearing mice. MOR-ir was undetectable in small tumours, but larger tumours demonstrated dense MOR-ir that co-localized with vascular and non-vascular compartments of the tumours. Morphine also promoted lymphangiogenesis, mast cell activation, and degranulation, and in the tumour microenvironment, it increased the levels of inflammatory cytokines, tryptase, and SP; the combination of these effects may underlie morphine-induced tumour progression.”

ncbi.nlm.nih.gov/pmc/articl....

[MouseAddams]

oh man… we’re damned if we do and damned if we don’t. Hubby uses morphine for his pain and can’t function without it. The pain is so bad he can’t move. He has tried oxy with no effect except to make him a zombie. However this study seems to show that the morphine is causing the mets he already has are sped up in growth by it. Including the ones in his liver?

[j-o-h-n]

Greetings marko.... If possible please update your bio......The info there will help us help you and it will help us too. All info is voluntary but here are some examples: age? location? psa number? meds? where being treated and etc. Thank you and to dick and his son.

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 10/13/ 2023 3:55 PM DST -- Ex wife's birthday.