Treatment Considerations for Prostate Cancer Progressing After Combination Therapy for mCSPC

[tango65]

A summary of approved treatments for metastatic PC.

urotoday.com/conference-hig...

[SPEEDYX]

Thanks Tango

...nice to have a concise informative picture on treatment's

[tango65 in reply to SPEEDYX]

Best of luck in your journey!!

[Shanti1]

Yes, this is helpful Tango- thanks!

[tango65 in reply to Shanti1]

Best of luck!!

[dockam]

Mahalo for that 💙

Had Lupron/Casodex and 15 Taxotere sessions in 2015. PSA went from 840.2 to 0.1 in 2017.

On Lupron/ Abiraterone since 01/2020 with T <3 PSA up to 4.9 🙄

So my next step would be Cabazitaxel plus?

I've also heard of adding Carboplatin to it.

Fight on Brothers

Randy

[Shanti1 in reply to dockam]

Mostly on this forum it seems that Carboplatin is suggested as an addition for those who have DNA repair mutations, for those who may have small cell/neuroendocrine variety and I have also seen that carboplatin is often added for those who have liver mets. However, Patrick recently posted this study: healthunlocked.com/advanced..., which may make one consider it, even without the situations above. I guess one has to weigh potential benift with a much tougher chemo regimen. Something to discuss with the MO.

[Hidden in reply to Shanti1]

I discussed it my MO and he said he would wait until a phase 3 trial before considering Carboplatin for anything other than NEPC or DNA repair mutations like BRCA2. He said it's a tough regimen.

[Shanti1 in reply to Hidden]

Thanks for the insight

[NOCanceros]

Thanks for the information.

Very useful.

3totango with John Travolta ....youtube

Niceday

[Newyork6264]

Great summary. Thank you.

[j-o-h-n]

I'm into colors too...... thanks.......

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 08/15/2020 11:20 AM DST

[monte1111 in reply to j-o-h-n]

I could send you some coloring books if you'd like. Only used once.

[j-o-h-n in reply to monte1111]

Thanks.... got any used cut out books???..........

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 08/15/2020 5:57 PM DST

[monte1111 in reply to j-o-h-n]

Funny. I do have some popup books that will pop your eyes out.

[j-o-h-n in reply to monte1111]

Edible?

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 08/15/2020 6:03 PM DST

[monte1111 in reply to j-o-h-n]

They used to be.

[j-o-h-n in reply to monte1111]

Who licked them?

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 08/15/2020 6:08 PM DST

[monte1111]

Something that is probably only of interest to me: I believe I am still Metastatic Hormone Sensitive. Psa <0.1, no progression or new lesions last scan. I started Xtandi after 8 cycles of chemo, August of 2017. FDA approval for Xtandi for MHSPca was December 2019. I'm not complaining, since Xtandi plus Lupron and etc. has worked 3 years and including chemo almost 3 and a half years. I'm just like almost everyone else here; waiting for the next best thing. Let's hope more options are added soon.

[tango65 in reply to monte1111]

I wonder why did they put you in Xtandi after chemo. Was the PSA going up?

[monte1111 in reply to tango65]

I went from high of 59.9 psa when I started chemo to about 7.0 when I started Xtandi. Then slowly downward to <0.1 Also prescribed Prednisone with the Xtandi. Much later, after reading this site, I objected to Prednisone and quit taking it. I'm just going to say that maybe I was a laboratory rat, and leave it at that.

[tango65 in reply to monte1111]

After they stopped chemo did the PSA went up? If it did and you were on ADT with a testosterone less than 50, then the cancer was castration resistant and Xtandi is an adequate treatment.

[monte1111 in reply to tango65]

My PSA has never gone up. Always down (so far). My testosterone has never been tested. (My bone density has never been tested either. I have a T12 compression fracture and cancer in several other spinal sites, pelvic sites and vertebrae. Skull was mentioned in prior scan. ) According to bone scan: all is stable. Abdominal lymph nodes are no longer mentioned.

[immunity1]

Thanks, useful summary. I especially support the idea of novel sequential treatments for mCRPC, or at least trying different families of drugs with a time period beween repeats, in order to eliminate different proposed clones of cancer cells.