Treatment Considerations for Prostate... - Advanced Prostate...

Advanced Prostate Cancer

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Treatment Considerations for Prostate Cancer Progressing After Combination Therapy for mCSPC

tango65 profile image
23 Replies

A summary of approved treatments for metastatic PC.

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tango65
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23 Replies
SPEEDYX profile image
SPEEDYX

Thanks Tango

...nice to have a concise informative picture on treatment's

tango65 profile image
tango65 in reply to SPEEDYX

Best of luck in your journey!!

Shanti1 profile image
Shanti1

Yes, this is helpful Tango- thanks!

tango65 profile image
tango65 in reply to Shanti1

Best of luck!!

dockam profile image
dockam

Mahalo for that 💙

Had Lupron/Casodex and 15 Taxotere sessions in 2015. PSA went from 840.2 to 0.1 in 2017.

On Lupron/ Abiraterone since 01/2020 with T <3 PSA up to 4.9 🙄

So my next step would be Cabazitaxel plus?

I've also heard of adding Carboplatin to it.

Fight on Brothers

Randy

Shanti1 profile image
Shanti1 in reply to dockam

Mostly on this forum it seems that Carboplatin is suggested as an addition for those who have DNA repair mutations, for those who may have small cell/neuroendocrine variety and I have also seen that carboplatin is often added for those who have liver mets. However, Patrick recently posted this study: healthunlocked.com/advanced..., which may make one consider it, even without the situations above. I guess one has to weigh potential benift with a much tougher chemo regimen. Something to discuss with the MO.

in reply to Shanti1

I discussed it my MO and he said he would wait until a phase 3 trial before considering Carboplatin for anything other than NEPC or DNA repair mutations like BRCA2. He said it's a tough regimen.

Shanti1 profile image
Shanti1 in reply to

Thanks for the insight

NOCanceros profile image
NOCanceros

Thanks for the information.

Very useful.

3totango with John Travolta ....youtube

Niceday

Newyork6264 profile image
Newyork6264

Great summary. Thank you.

j-o-h-n profile image
j-o-h-n

I'm into colors too...... thanks.......

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 08/15/2020 11:20 AM DST

monte1111 profile image
monte1111 in reply to j-o-h-n

I could send you some coloring books if you'd like. Only used once.

j-o-h-n profile image
j-o-h-n in reply to monte1111

Thanks.... got any used cut out books???..........

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 08/15/2020 5:57 PM DST

monte1111 profile image
monte1111 in reply to j-o-h-n

Funny. I do have some popup books that will pop your eyes out.

j-o-h-n profile image
j-o-h-n in reply to monte1111

Edible?

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 08/15/2020 6:03 PM DST

monte1111 profile image
monte1111 in reply to j-o-h-n

They used to be.

j-o-h-n profile image
j-o-h-n in reply to monte1111

Who licked them?

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 08/15/2020 6:08 PM DST

monte1111 profile image
monte1111

Something that is probably only of interest to me: I believe I am still Metastatic Hormone Sensitive. Psa <0.1, no progression or new lesions last scan. I started Xtandi after 8 cycles of chemo, August of 2017. FDA approval for Xtandi for MHSPca was December 2019. I'm not complaining, since Xtandi plus Lupron and etc. has worked 3 years and including chemo almost 3 and a half years. I'm just like almost everyone else here; waiting for the next best thing. Let's hope more options are added soon.

tango65 profile image
tango65 in reply to monte1111

I wonder why did they put you in Xtandi after chemo. Was the PSA going up?

monte1111 profile image
monte1111 in reply to tango65

I went from high of 59.9 psa when I started chemo to about 7.0 when I started Xtandi. Then slowly downward to <0.1 Also prescribed Prednisone with the Xtandi. Much later, after reading this site, I objected to Prednisone and quit taking it. I'm just going to say that maybe I was a laboratory rat, and leave it at that.

tango65 profile image
tango65 in reply to monte1111

After they stopped chemo did the PSA went up? If it did and you were on ADT with a testosterone less than 50, then the cancer was castration resistant and Xtandi is an adequate treatment.

monte1111 profile image
monte1111 in reply to tango65

My PSA has never gone up. Always down (so far). My testosterone has never been tested. (My bone density has never been tested either. I have a T12 compression fracture and cancer in several other spinal sites, pelvic sites and vertebrae. Skull was mentioned in prior scan. ) According to bone scan: all is stable. Abdominal lymph nodes are no longer mentioned.

immunity1 profile image
immunity1

Thanks, useful summary. I especially support the idea of novel sequential treatments for mCRPC, or at least trying different families of drugs with a time period beween repeats, in order to eliminate different proposed clones of cancer cells.

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