Is anyone of the opinion that Morphine can accelerate breast, prostate or other cancer progression? I was looking up wether morphine can activate mast cells and found the following:
“We demonstrate that morphine does not influence cancer initiation, but it stimulates the progression of spontaneously developed breast tumours and shortens the survival of tumour-bearing mice. MOR-ir was undetectable in small tumours, but larger tumours demonstrated dense MOR-ir that co-localized with vascular and non-vascular compartments of the tumours. Morphine also promoted lymphangiogenesis, mast cell activation, and degranulation, and in the tumour microenvironment, it increased the levels of inflammatory cytokines, tryptase, and SP; the combination of these effects may underlie morphine-induced tumour progression.”