ADT (Lupron) and creatine?

[Gs-rider]

57 yo Swede here. Diagnosed nine months ago 4+3. I am on Lupron after RALP (unclear margins) and 35 times ERBT. I do serious weight training and supplement with Whey protein. I am curious about creatine supplement. intake. Is it safe? I have not read anything against, but nothing that makes me feel totally safe about it eather. Any studies on creatine with PCa and ADT out there? Thank you for tips on this matter.

[mrscruffy]

I have been taking creatine and BCCA's for years. I have been taking Ostarine for about a year now. All approved by my MO

[Captain_Dave]

I Googled 'Creatine Prostate Cancer' and there are several articles. This is the title of one article "Higher Creatinine Levels Linked to Increased Prostate Cancer Risk"

Link to article: renalandurologynews.com/hom...

[Seasid in reply to Captain_Dave]

In the USA in Florida they have a clinical trial with creatine monohydrate. Maybe you should contact the clinical trial official and ask your question. The trial participants are all mPC people:

cancer.gov/about-cancer/tre...

I am personally reluctant to take creatine as it can help our body to produce DHT and that is a very powerful androgen which is not welcome to prostate cancer sufferers. I also wish to know the proper safe answer to your question about creatine monohydrate and PC.

[Seasid in reply to Seasid]

My MO wasn't happy that I want to use creatine monohydrate.

[Seasid in reply to Seasid]

Resistance Training with or without Creatine Monohydrate Supplement in Improving Body Composition and Health Outcomes in Patients with Metastatic Prostate CancerTRIALSTATUS: ACTIVE

Description

This trial studies how well resistance training with or without creatine monohydrate supplement works in improving body composition and health outcomes in patients with prostate cancer that has spread to other places in the body (metastatic). Resistance training, with or without creatine monohydrate supplement, may help to improve feelings of tiredness and overall physical function in patients with prostate cancer.

[Seasid in reply to Captain_Dave]

Could you please remove your link as it could only confuse people as creatinine is not the same as creatine. Therefore your link is not appropriate to this discussion.

[32Percenter in reply to Seasid]

The info may still be relevant. Creatine is broken down into creatinine before it clears the body, so are elevated creatine levels in the body through supplementation possibly a cause of this correlated risk?

Years before prostate cancer I had high creatinine levels after a physical-related blood test. My GP was anxious but after I told him about my creatine use, I washed out for a month and tested again. Creatinine levels then came back normal.

[Seasid in reply to 32Percenter]

I understand what you are saying but still I would treat your information about creatinine study as possibly not relevant.

But I definitely lost my will to supplement with creatine monohydrate and to take the advice of my MO. My problem is that creatine could be beneficial to my bones and it would help me with my osteoporosis.

[TuffNuttoCrack]

my suggestion, switch to other plant based protein supplements. I would make a suggestion but I would likely be banned for promotion. Find one that is less than a dozen ingredients. The first letter of one I use starts with a letter after e. Not a bodybuilder but someone working their tail off to get muscles like yours. Best Tuff Nut

[j-o-h-n]

Greetings Gs-rider.

Hey if guys ingest dog wormer and don't let out a bark about it....then taking creatine to build up your strength means........ there's no two wheys about it.........

(p.s. Please update your bio, it helps)...

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 10/08/2023 6:09 PM DST

[Mike1971]

I’ve been thinking about supplementing with creatine as well, but found the following which makes me reconsider:

aacrjournals.org/cancerres/...

In prostate cancer, the concept of resistance training is being considered to tackle androgen deprivation therapy induced loss of lean body mass. Hence, creatine supplementation is studied as an ongoing lifestyle intervention in a clinical trial for prostate cancer (19). Our observation of increased cellular proliferation in tumors from Ptenpc−/− Spry2pc−/−mice following creatine supplementation for only eight weeks highlights the need to assess creatine supplementation in patients with prostate cancer with caution. Consistent with our findings, dietary uptake, or GATM-mediated de novo synthesis of creatine, enhanced cancer metastasis and shortened mouse survival

[Gs-rider in reply to Mike1971]

Thank you Mike1971! It is this kind of reports that makes me unsure. I will stay with resistanse training and a wise diet.

[Mgtd in reply to Gs-rider]

Me too.

[32Percenter in reply to Mike1971]

IGF-1 is great for muscle growth, but also for tumor growth. Same with MTOR.

Would increasing ATP through creatine or D-ribose supplementation have a similar effect? Possibly. Aren't most cancer cells anaerobic and thrive on glucose and ATP?

[Mike1971 in reply to 32Percenter]

Hi 32Percenter,

I don’t know the answers to your questions, but I do like the idea behind your username 👍

[Derf4223]

Having PCa and ADT-related LT SE's is a game of tradeoffs. Lots of exercise seems to be the best odds-improver with no downside. My MO has said that there are no supplements that affect PCa and has no issue with my taking creatine, taurine, HMB, and L-theanine. On ADT we also experience bone loss. My DEX scan after a few months on ADT = osteopenic, and my MO said I had no chance of offsetting bone loss without Prolia. I won't know how that worked until the next DEX scan next year, but also take Calcium, D3, K2 and magnesium.

[32Percenter]

If the risk is there, why do it?

Even though the marketing behind creatine would lead people to believe they'll see "steroid-like" gains, the actual effects of creatine are relatively mild. I used it for years on and off, and at best saw a 5-10% increase in strength (and that was with full natty testosterone, when exercise response is strongest). It also went away after I stopped taking it.

If you're concerned it might stimulate your cancer, only to squat 220lbs instead of 200lbs for a transient period, the risk vs. reward isn't worth it IMHO.

[Cactus297]

As far as I know whey protein is an inexpensive biproduct of dairy. Not so good for lactose intolerance. I think non gmo or non dairy organic protein would be a better alternative but this is just my humble opinion not from a doctor and I am sensitive to dairy and also a woman.

[Mascouche]

For a little over a year I've been supplementing with a protein mix that contains HMB in it. It doesn't help in young adults but with older folks it appears to reduces muscle loss with or without exercising though exercise is preferable of course.

en.m.wikipedia.org/wiki/%CE...