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I wonder if body builders using creatine get less cancer

Graham49 profile image
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J Exp Med. 2019 Dec 2;216(12):2869-2882. doi: 10.1084/jem.20182044. Epub 2019 Oct 18.

Creatine uptake regulates CD8 T cell antitumor immunity.

Di Biase S#1, Ma X#1, Wang X1, Yu J1, Wang YC1, Smith DJ1, Zhou Y1, Li Z1, Kim YJ1, Clarke N1, To A1, Yang L2,3,4,5.

Author information

Abstract

T cells demand massive energy to combat cancer; however, the metabolic regulators controlling antitumor T cell immunity have just begun to be unveiled. When studying nutrient usage of tumor-infiltrating immune cells in mice, we detected a sharp increase of the expression of a CrT (Slc6a8) gene, which encodes a surface transporter controlling the uptake of creatine into a cell. Using CrT knockout mice, we showed that creatine uptake deficiency severely impaired antitumor T cell immunity. Supplementing creatine to WT mice significantly suppressed tumor growth in multiple mouse tumor models, and the combination of creatine supplementation with a PD-1/PD-L1 blockade treatment showed synergistic tumor suppression efficacy. We further demonstrated that creatine acts as a "molecular battery" conserving bioenergy to power T cell activities. Therefore, our results have identified creatine as an important metabolic regulator controlling antitumor T cell immunity, underscoring the potential of creatine supplementation to improve T cell-based cancer immunotherapies.

© 2019 Di Biase et al.

PMID: 31628186 PMCID: PMC6888972 DOI: 10.1084/jem.20182044

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Graham49
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rocket09 profile image
rocket09

Great , Thanks.

keepinon profile image
keepinon

I am on about month 10 of Lupron +Z+P. I lift weights 3 times a week and have been able to maintain most of my strength but my arms have become the arms of a skinny 12 year old. In your opinion would creatine be a good thing to add?

Kuanyin profile image
Kuanyin

I think this is a two-fer: help conserve muscle mass while building up immunity. I have sent a copy of the article to my MO to see whether or not their might me a downside, at least for my particular situation.

--K

GeorgeGlass profile image
GeorgeGlass in reply toKuanyin

What did your ammo have to say?

Kuanyin profile image
Kuanyin in reply toGeorgeGlass

Hi George,

He offered no objections. Actually, it was my own concerns that led me to not take it. My two concerns are (1) it would increase my blood creatinine which is a measure of kidney function--in other words taking creatine might mask a kidney problem (Creatinine clearance (CrCl) is the volume of blood plasma cleared of creatinine per unit time. It is a rapid and cost-effective method for the measurement of renal function. Both CrCl and GFR can be measured using the comparative values of creatinine in blood and urine. Glomerular Filtration Rate.); (2) I am 81, what results can I seriously look forward to? Going to the gym, up until now, three times a week was sufficient to maintain functional strength, anything else, I have my weight-training son to assist.

--K.

GeorgeGlass profile image
GeorgeGlass in reply toKuanyin

Make sense. Thanks K. My creatinine test came back today. It was on the lowest possible number in the normal range. Thus, I think I have some leeway room to take 5mg a day and see how it goes. I need a little more iron and zinc too. Good that you and your son are working out together. Nice.

George

keepinon profile image
keepinon

Thanks for the reply. I will probably pass on it for now. Taking enough stuff already.

dentaltwin profile image
dentaltwin

Ahh, creatine (AKA "Krebiozen")--I'm getting a flashback to my youth!

en.wikipedia.org/wiki/Krebi...

GeorgeGlass profile image
GeorgeGlass

Has anyone discovered any new info on adding creatine? Will it change a1c and blood glucose levels? Did the MO have an opinion? Is anyone using while on adt?

GeorgeGlass profile image
GeorgeGlass

Nalakrats, do you see any issue with taking creatine while on ADT?

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