Cabazitaxel, can you return for a second round.

[docbulldog]

I was only on this chemo, Cabazitaxel, for three infusions, then was approved for Pluvicto . PSA was creeping up slowly during that time, from 63-141.

Has anyone gone back to it and had success with 8-10 infusions?

I am now being treated with docetaxel(50%) and carboplatin, both at a reduced percentage, because of a low platelet count and fairly severe neuropathy. I have received five infusions, spaced out over four weeks primarily, having started January 30. My PSA has gone from 758 down to 176. Onc want to go with Carboplatin only in 4 weeks.

[Tall_Allen]

This clinical trial combines Xofigo with a reduced chemo dosage:

classic.clinicaltrials.gov/...

[docbulldog in reply to Tall_Allen]

I was hoping to get away from Docetaxel since it adds more neuropathy to already challenged feet. PSA went from 20.13 to 30.21 and settled out at 13.33 after 7 months and 10 infusions. Two monthes later it rose to 62.84, so I guess I can say it was helping but causing exploding neuropathy. I guess I had better rethink it's use.

I had several visiting Onc's during this time period and wasn't keeping track of my own treatment. And because of the 3 different Onc's with different discussions during treatment I think I became complacent....My Bad! ... one had me switch to dexametasone after 5 infusions.... not sure good or bad.

I will get my new resident Onc on this trial information.

Thanks for your imput TA.

[Ian99 in reply to docbulldog]

Are you using frozen socks and mittens during the chemo sessions?

[docbulldog in reply to Ian99]

I sent them back, tried one time but was not impressed. Maybe I should reconsider if i continue with docetaxel.

[docbulldog in reply to docbulldog]

I will be on a Cabazitaxel infusion with no Docetaxel starting next week. Hopefully that chemo does not caused more neuropathy. Also, hoping my PSA will continue to drop but I am wondering if it is the Docetaxel that has been pushing that down.

[Ian99]

I had chemo 9 years ago and was not told about this. I have neuropathy equally in both feet ever since. It may not be SOC in some health services but it has been shown time and again to work. I strongly recommend it.

Here is an article from a Times of London journalist recounting her own experience.

Relief for cancer patients is being frozen out

thetimes.co.uk/article/5970...

Good luck.

[docbulldog]

I was told yesterday that continuing with chemo would be devastating to my cells, so I am now off treatment.

I will meet with my Onc in 3 weeks and go over a lab I'll have prior to the visit.

Hoping there is something new in the making, I'm not ready to give up on a successful treatment.