Began my 3rd round of chemo 3 weeks ago with same combo of Docetaxel/Carboplatin as the prior 12 infusions. This time Med Onc suggested we continue Xtandi, which had been used on a rechallenge basis after the prior 2 rounds of chemo, but NEVER during chemo.
Results were impressive. PSA dropped from 2.8 to .5 with this combination. Xtandi on pure rechallenge basis had brought PSA down from 48 to 2.8.
Combination of Xtandi and chemo gives me renewed hope for a durable remission if liver mets are positively impacted. Will know for sure in a couple of weeks with next liver MRI.
Best Wishes. Never Give In.
Mark, Atlanta
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vandy69
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Thanks for the link. I have been heavily treated with every drug, proton beam radiation, and now 3rd round of chemo. 7+ years since dx with multiple lymph node mets, mets in liver 2 years ago, and still here!
That’s wonderful, Mark. Your multiple rounds are inspirational. I’ve so far been on an almost 3 year round 1 (docetaxel+carboplatin +bicalutamide followed by lupron+Zytiga). It’s encouraging to see things like this when/if my Mets/psa change down the road. Keep the faith! Doug✌️
I am currently on a trail using Jevtana and Xtandi, Consists of 10 cycles reduced Jevtana dose with ongoing Xtandi. My psa was rising rapidly back when I was on another chemo and I had liver problems with Zytiga. With the Jevtana and Xtandi my psa has dropped from 10.88 to .50 and my scans are showing no progression. I am getting the impression from the trial coordinator that things are going well for me and many others on this combination of prior approved FDA treatments. Nice thing is with prior approved FDA treatments they should be able to approve the combination of the two at a much faster rate.
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