I just posted this update to my profile:
UPDATE: June 5, 2023: I am continuing to take Orgovyx and my most recent PSA was again. <.02 in April. Also in April, I restarted my experiment with Estradiol patches as a treatment for osteoporosis and ADT SEs. I started on one 0.25 patch twice per week. Today was 6 weeks and I had Estradiol and Testosterone blood tests. Estradiol was <24 and Testosterone was 16, where it has been since I began Orgovyx in late 2021. As of June 5, I continue to experience some nipple tenderness which began after the second week on the patch.
This seems like a decent E2 blood level so far. I'm also wondering how long does the nipple tenderness persist?