Treatment Options PSA Increasing While on Lupron

[dac500]

I have been on intermittent ADT (Lupron/Eligard) from November 2018. During the last Lupron cycle my stopped going down. I got the first shot of this cycle in July, 2022 when my PSA was 0.56. By October it went down to 0.29 when got another shot. However, in January 2023 my PSA went up by a small amount to 0.32.

I am going for another shot on Monday, April 24. Should another ADT like Zytiga be added if PSA continues increasing by a small amount? Say to 0.40. Or should I wait until PSA rises considerably.

If PSA shows sign of going down, should I continue only with Lupron until PSA is undetectable (<0.1)?

[dac500]

Correction my PSA stopped going down...

[tango65]

Your PSA is stable at 0.3.

If it goes up to 0.4-0.5, consider requesting a PSMA PET/CT and if mets can be visualized you should consider a new plan of treatment. Adding Zytiga could be a good option.