I'm a 70 year old, healthy person who has faced no major health issues (or addressed them quickly.) I'm retired and live alone.
After pushing for PSA test, I had 6 in 6/22 and 20 in 8/22. Biopsy in 9/22 showed Gleason 4+5=9 and classified as stage 4. Bone scan and Cat showed small metastices in spine, hip, lung, & shoulder. Other than urinary incontinence, no other symptoms.
Quickly started Lupron and added Abiraterone by December. Switched insurance/institutions and went to regional cancer center. Added docetaxel and have finished 4./6 treatments. Next is tomorrow and final in May.
In November, I found that I have the Braca 2 gene. I am Ashkenazi Jew. Maternal grandfather died of breast cancer, and mother died of Pancreatic cancer with a few weeks of diagnosis.
PSA had gone up to 20 (but I'm told that the finasteride I'd been taken means I should consider that as 40.
PSA went down to .03 and has remained low.
Side effects have been weakness, mouth ulcers, complete loss of taste, hair loss, two UTIs and two digestive infections (entamoeba and C. difficile....all quickly treated.).
I have heard good and bad things about the quick reduction in PSA.
After I finish chemo (docetaxyl) in May, I might join a medical trial which will compare adding a Parp inhibitor while ADT is still working.
I have been growing culinary mushrooms at home, and have also been successful with Reishi, LionsMane, Turkeytail as well. I can test to be certain I am producing what I expect. And I am confident that I can grow other types.
It is hard for me to fully understand the studies, but I think I have only read good things about adding mushrooms (button and trametes) to treatment with few if any side effects. I realize there are factors that I do not fully understand.
My own doctors spoke with the Pharmacist and recommended against adding mushrooms. I believe they have all been open minded, but they are human, and I don't know how much they have researched.
I can accept that they may not be good for me. But if there are no problems and they may help, I'd lean towards adding Trametes versicolor (TurkeyTail). I'd use both ethanol and water to extract what I can and take the resulting extract. I would also dehydrate and grind to add to my meals.
Can anyone provide me with insight re adding Turkey Tail and how? I would want to bring supporting data to my Oncologist. I appreciate any information. I realize that research may not apply to MY situation.
Personal, anecdotal information is also appreciated, but of less value.
Thank you.
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DoubleBlind
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Not about mushrooms (I have no opinion about that), but I have an observation about your therapy. I certainly encourage the PARP inhibitor trial. Just today, I ran across the following trial:
Sorry i can't point you to studies, but i researched them when i was diagnosed 7 years ago, and all i can say is how amazing all the different mushrooms are you mentioned, sounds like your doing an amazing job with what your doing, i like to get as many of them down me as possible, i like to think of it like this, the Chinese have been using medicinal mushrooms for 5000 years, you don't do something that long if they don't do anything, its not to say they'll cure you but they can be a big help in your overall well being, you can use them as adjunctive treatments along with medical treatments to enhance the treatment and to help with side effects, i personally try to get as much down me as i can, i feel they will only help 😀
Can't say much about mushrooms but they seem to improve immune system. I would recommend that you add lycopenes to your diet to assist the ADT in your fight against APC.
I met with MSKCC Alternative Medicine Oncologist and he suggested Turkey Tail above others I was taking at the time (Reishi Spore Oil being one)... Polysaccharides have some powerful effect. Interestingly, it's always a conundrum as just like SOC drugs, finding what works for "YOU" is the trick!
In Japan, turkey tail extract also goes by the name Kawaratake. Today PSK is available for use for cancer patients in Japan. In that country, it is commonly prescribed as a cancer treatment, sometimes in conjunction with more traditional methods such as chemotherapy, surgery, and radiation.
PSK: Popular Japanese Cancer Treatment STILL Not Approved in t…
WebMar 2, 2017 · PolysaccharideK (PSK) is the best known active compoundin turkey tail mushrooms. In Japan, PSK is an approved mushroom product used to treat cancer. How …
WebJul 29, 2022 · Polysaccharide K (PSK) is the best known active compound in turkey tail mushrooms. In Japan, PSK is an approved mushroom product used to treat cancer. How …
Creatine has been identified as an important metabolic regulator conserving bioenergy to power CD8 T cell antitumor reactivity in a tumor microenvironment; creatine supplementation has been shown to enhance antitumor T cell immunity in multiple preclinical mouse tumor models and, importantly, to synergize with other cancer immunotherapy modalities, such as the PD-1/PD-L1 blockade therapy, to improve antitumor efficacy.
Author: Bo Li, Lili Yang
Publish Year: 2021
Creatine in T Cell Antitumor Immunity and Cancer Immunotherapy
Remember that synergy is a powerful factor. There was a study funded by a non-profit that found that large amounts of green tea, curcumin, pomegranate and cruciferous supps did little to kill cultured prostate cancer cells. The men had blood drawn after eating the supps which was used to kill prostate cancer cells. When small amounts of all the sups were given in combination, surprisingly, the men's blood killed the prostate cancer cells at a high rate. Pomi-T is likely based on that study. Funded by a non-profit, the money ran out with just these four supps combined.
Another study mentioned in the article below about the combining these four supplements.
WebJun 10, 2013 · After six months, the researchers found that PSA levels were 63% lower among those taking capsules containing essence of pomegranate, turmeric, green tea …
Bromelain not only helps one digest and absorb one's foods but also is an anti-inflammatory. Supplement manufacturers add piperine to hard to digest supps for a reason--it helps one's body absorb the nutrients. Black pepper is a spice that I enjoy on many foods, especially salads. Broccoli sprouts are perhaps the number one cancer killer as a vegetable. Mustard was found to increase the absorption of broccoli sprouts as a high-quality olive oil helps us to absorb nutrients too. Garlic, an allium, is said to be number two cancer killer. Kyolic claims that their supp is superior to fresh garlic as it is aged to increase it's potency. Blueberries are said to be the number one cancer killing fruit.
There is much to read about and accessible on the net. Remember, if it sounds too good to be--Ahh you know the rest!
Do what is needed with your doctors but remember that diet can help. Eat that which cancer doesn't like and strengthens the immune system and avoid the foods that feed cancer and weaken the immune system
Good for you taking Turkey Tail mushrooms that you grow yourself so they are organic.
many of us have studied mushrooms and the healing effect they can produce. I have studied ABM, maitake, Reishi, and Shitake. all 4 provide a superior source of nutritional support for your immune system. I plan to write about healing mushrooms in another one of my posts.
If your doctors are saying no to mushrooms, I say find better doctors. I am not convinced fully that mushrooms are the answer to every medical problem but saying not to take them is like saying don't eat vegetables. I took various mushroom supplements with high PSK while doing radiation to help immune system. Had no problems but of course I did not also do the same without them. I made it a point to find supplements that were extracted with both water and alcohol and not just ground up fruiting bodies, just as you are doing.
Wonderful reply !!!!!!. Yes mushrooms are a vegetable you can eat.. Doctors are NOT trained in nutrition. they learn cut, burn and poison. My little nutritionist joke. cut is surgery, burn is radiation and drugs is poison.
I'm not saying drs are bad. I have had many drs in my family and one surgeon so .....I respect them. I'm just full of humor. lol🦊
“My little nutritionist joke. cut is surgery, burn is radiation and drugs is poison.”
Dear god, seriously?
Most of the guys with stage 4 cancer in here would be dead if it weren’t for drugs. What a horrible philosophy to spread. Many other drugs for many conditions provide benefit without any toxicity.
Are some cancer drugs like taxotere poison? Sure, but they still save lives, or at least prolong them.
You can’t cure advanced prostate cancer with mushrooms and vegan diets. I’m still not sure what kind of cancer you claim to have had cured by juicing ala Chris Wark, but even that guy had surgery to remove his cancer.
Yes, I wrote that I respect drs and it was just a little humor. In fact, my aunt the surgeon, would tell her patients that she was going to cut them, then burn the cancer tissue and finally poison them with drugs.........she got them to laugh which is something. I wish you much happiness in your heart. :)💜💜
my home apothecary is full of so many different mushrooms I have wild harvested over the years. Still on the hunt for shagy mane which needs immediate immersion in alcohol. I alway hit my mushrooms gills up with the sun or in fall i use both the sun and an iquana lamp to increase the vit D. I have 30 shiitake logs and am already getting shrooms which is really early this year.
The two faces of Coprinus comatus—Functional properties and potential hazards
3.3. Anticancer potentialCC extract can modulate viability and proliferation of cancer cells. Zaidman et al. proved that ethyl acetate extract from CC inhibited proliferation of androgen‐sensitive human prostate adenocarcinoma cells LNCaP, through decreasing transcriptional activity of androgen receptors (AR). Coprinus comatus extract decreased activity of luciferase—enzyme which reveals AR transcriptional equal to the level of prostate‐specific antigen (PSA), which is a glycoprotein marker used for staging and screening of prostate cancer. The treatment with CC ethyl acetate extract inhibited PSA level by 77% (Zaidman et al., 2008). Dotan, Wasser, and Mahajna indicated that hexane extract showed the strongest antiandrogenic effect compared with ethyl acetate, chloroform, or ethanol extracts from CC (Dotan et al., 2011). The extract decreased PSA mRNA and AR protein level in LNCaP cells, inhibited colony formation in LNCaP cells and AR transcription activity in MDA‐kb2 cells. The study presented CC as an antiandrogenic modulator that could improve treatment of prostate diseases
White button mushroom (WBM) (Agaricus bisporus) is a potential prostate cancer (PCa) chemopreventative and therapeutic agent. Our clinical phase I trial of WBM powder in patients with biochemically recurrent PCa indicated that WBM intake reduced the circulating levels of prostate-specific antigen (PSA). We hypothesized that WBM exerts its effects on PCa through the androgen receptor (AR) signaling axis. Therefore, we conducted a reverse translational study with androgen-dependent PCa cell lines (LNCaP and VCaP) and patient-derived-xenografts (PDX) from a prostate tumor (TM00298). In both LNCaP and VCaP cells, western blots and qRT-PCR assays indicated that WBM extract (6~30 mg/mL) suppressed DHT-induced PSA expression and cell proliferation in a dose-dependent manner. Immunofluorescence analysis of AR revealed that WBM extract interrupted the AR nuclear-cytoplasmic distribution. PSA promotor-luciferase assay suggested that WBM extract inhibited DHT-induced luciferase activity. RNA-Seq on WBM-treated LNCaP cells confirmed that WBM treatment suppressed the androgen response pathways and cell-cycle control pathways. Our PDX showed that oral intake of WBM extract (200 mg/kg/day) suppressed tumor growth and decreased PSA levels in both tumors and serum. In the present study, we also identified a conjugated linoleic acid isomer (CLA-9Z11E) as a strong AR antagonist by performing LanthaScreen™ TR-FRET AR Coactivator Interaction Assays. The inhibitory effect of CLA-9Z11E (IC50: 350 nM) was nearly two times stronger than the known AR antagonist, cyproterone acetate (IC50: 672 nM). The information gained from this study improves the overall understanding of how WBM may contribute to the prevention and treatment of PCa.
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