Xofigo should stop or continue.

[11redtomato_41]

86-year-old, Dx with advanced prostate cancer in 2018, done, Zytiga with prednisone, EBRT, Xtandi, Earlida, Nubequa and Docetaxel chemo up to 4th done, then, had to stopped because psa continue rising from 1420 from 845 in a 4weeks. Akl Phos also climb up to 1194 from 706 in 4wks.

His bone pain become worse and terribly tired, and no appetite. His health declines every day and now may not be able to walk by himself in matter of 1 or 2 days because of pain and weakness in legs. Xofigo seems not helping at all and what to do. See RO in a week.

Thank you in advance

[HopingForTheBest1]

Sorry to hear about his worsening condition and experienced side effects. Age is definitely a factor as to the effectiveness of treatments. At this point it becomes how well his body can handle their side effects. Make use of palliative care to deal with pain.

[Frigataflyer in reply to HopingForTheBest1]

I am 79 and was diagnosed in december 2018 when my PSA was 176. Since then i have taken Casodex, Zytiga, Enzalutamide ,20 shots of radiation, two courses of Docetaxel, in one course the Docetaxel was combined with carboplatin. My PSA nadir was 2.05. But now my PSA is raging ( increase from 48 to 316 in five weeks).

My guts are in terrible shape from being carpet bombed by meds over the years and I have painful inflammation in my abdomen.

At this point I am giving up on meds, trying to repair my gut and exploring palliative care and voluntary cessation of eating and drinking.

[Margoto in reply to Frigataflyer]

It is a difficult decision, but most likely a wise one. Best of luck for a more comfortable life.

[11redtomato_41 in reply to HopingForTheBest1]

Thank you so much indeed. Will discuss with RO in a week. So thankful to you.

[11redtomato_41 in reply to HopingForTheBest1]

Thank you so much for your sincere advice. Found pain killer helps him. Thank you.

[MateoBeach]

So sorry. Discuss home hospice care.

[11redtomato_41 in reply to MateoBeach]

Thank you for a good advice that may help me the plan.

Bless you.