Diagnosed 11-9-21. PSA 1998, ALK PHOS 750, Gleason 4+5. Lots of mets mostly bone. 11-17-21 started treatment. 3 month Lupron injection followed 2 days later with 4 month Zometa and 1st of 6 cycles of docetaxel. At 2nd chemo PSA 301, ALK P 1730. At completion of chemo 4-8-22 PSA 2.45, ALK P 280. Today I am still on the Lupron / Zometa treatment with PSA .32 (PSA has continued to drop some every blood test), ALK P 81. I do take low dose Morphine for the pain. After reading on the site it seems a more aggressive approach to drop my PSA would have been best. My pain is beginning to increase so it might be to late anyway. My question is, should I be doing more or is what I’m doing good until a scan or blood work shows something different. Thanks.
Should I be doing more. : Diagnosed 1... - Advanced Prostate...
Should I be doing more.
What have your follow-up scans showed? Any new mets? Any shrinkage of existing ones? As per PEACE-1 trials, current SOC is triplet therapy for newly diagnosed; but too late for that. Have you asked about 2nd layer of ADT - Zytiga, Xtandi.....
You should add either Abiraterone, Enzalutamide, Apalutamide or Darolutamide to lupron. This is the standard of care for you. You could also get your bones radiated to mitigate the pain.
I think this would be a good time for Xofigo. Here are some good combinations to discuss with your oncologist:
prostatecancer.news/2021/02...
Xofigo is also for when one is still hormone resistant ?
Xofigo is only for those who are hormone resistant. Triplet is for those who are newly diagnosed as metastatic and hormone sensitive.
Thank you for the reply’s. My scans have stayed pretty much the same. Stable and similar to prior exams seems to be a common term in my CT and bone scans. I will discus these options with my doctor. Thanks again.
Sounds like things are going well. I too, had six docetaxel treatments over 18 weeks, 44 months ago, still no detectable PSA. Only additions I had were daily Protectival tablet, three times daily, and the Care Oncology Protocol (CareOncology.com). Hope this is helpful!
Add second tier.....erleada or such.....
PSA incr-should continue Zytiga ?&bone mets incr but ok CT //OTC pills now-- what dr. manages pain progression?
Results are in!
Preparation Thoughts if PSA Rises
