Ivermectin and Cancer: Exploring the Potential Link ...
Yes, ivermectin can reduce prostate-specific antigen (PSA) levels. Ivermectin is a drug that can inhibit the growth of prostate cancer cells and may be a potential treatment for prostate cance How ivermectin reduces PSA levels :
Reduces AR protein expression
Ivermectin reduces the expression of androgen receptor (AR) protein, which can lead to a reduction in PSA levels.
Inhibits AR-V7 protein expression
Ivermectin reduces the expression of AR variant 7 (AR-V7) protein, which can also lead to a reduction in PSA levels.
Inhibits HSP27
Ivermectin inhibits HSP27, which is linked to resistance to chemotherapy.
Inhibits FOXA1 and Ku70/Ku80
Ivermectin interacts with FOXA1 and Ku70/Ku80, which can block AR signaling transcription and DNA double-strand break repai be a potential treatment for prostate cancer.
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I repeated your prompt in ChatGPT 4o and received the opposite reply:
Can invermectin lower psa levels?
ChatGPT said:
ChatGPT
Currently, there is no reliable scientific evidence or clinical data to suggest that ivermectin lowers prostate-specific antigen (PSA) levels. PSA levels are typically used as a marker for prostate health, particularly in the context of prostate cancer or other prostate-related conditions, such as benign prostatic hyperplasia (BPH) or prostatitis.
Key considerations:
Ivermectin's Approved Uses: Ivermectin is an antiparasitic medication approved for treating conditions like onchocerciasis, scabies, and other parasitic infections. Its mechanism of action involves binding to parasite-specific proteins, which is unrelated to PSA production or prostate health.
Emerging Research on Ivermectin in Cancer: Some preclinical studies (e.g., in cell cultures or animal models) have explored ivermectin's potential anti-cancer effects due to its ability to inhibit certain cellular pathways. However, these studies are preliminary, and no established connection has been made between ivermectin and lowering PSA or treating prostate cancer.
PSA and Underlying Conditions: PSA levels are influenced by many factors, including cancer, infection, inflammation, or recent physical activity affecting the prostate (e.g., ejaculation or a digital rectal exam). Effective PSA management depends on addressing the underlying cause rather than using off-label treatments without clinical evidence.
If you or someone you know is concerned about elevated PSA levels or considering alternative therapies, it’s critical to discuss this with a healthcare provider or oncologist. Misusing medications like ivermectin without evidence-based guidance could delay proper diagnosis and treatment.
FURTHER:
ChatGPT 4o
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You said:
Can invermectin lower psa levels
ChatGPT said:
ChatGPT
Currently, there is no reliable scientific evidence or clinical data to suggest that ivermectin lowers prostate-specific antigen (PSA) levels. PSA levels are typically used as a marker for prostate health, particularly in the context of prostate cancer or other prostate-related conditions, such as benign prostatic hyperplasia (BPH) or prostatitis.
Key considerations:
Ivermectin's Approved Uses: Ivermectin is an antiparasitic medication approved for treating conditions like onchocerciasis, scabies, and other parasitic infections. Its mechanism of action involves binding to parasite-specific proteins, which is unrelated to PSA production or prostate health.
Emerging Research on Ivermectin in Cancer: Some preclinical studies (e.g., in cell cultures or animal models) have explored ivermectin's potential anti-cancer effects due to its ability to inhibit certain cellular pathways. However, these studies are preliminary, and no established connection has been made between ivermectin and lowering PSA or treating prostate cancer.
PSA and Underlying Conditions: PSA levels are influenced by many factors, including cancer, infection, inflammation, or recent physical activity affecting the prostate (e.g., ejaculation or a digital rectal exam). Effective PSA management depends on addressing the underlying cause rather than using off-label treatments without clinical evidence.
If you or someone you know is concerned about elevated PSA levels or considering alternative therapies, it’s critical to discuss this with a healthcare provider or oncologist. Misusing medications like ivermectin without evidence-based guidance could delay proper diagnosis and treatment.
You said:
please provide references for the above
ChatGPT said:
ChatGPT
Currently, there is no reliable scientific evidence or clinical data to suggest that ivermectin lowers prostate-specific antigen (PSA) levels. While some preclinical studies have explored ivermectin's potential anti-cancer effects, these investigations are preliminary and primarily conducted in laboratory settings. For instance, a study published in Nature reported that ivermectin induced cell cycle arrest and apoptosis in prostate cancer cells; however, these findings are limited to in vitro experiments and have not been validated in human clinical trials.
It's important to note that PSA levels can be influenced by various factors, including benign prostatic hyperplasia (BPH), prostatitis, and certain medications. Medications such as 5-alpha reductase inhibitors, commonly used to treat BPH, have been shown to lower PSA levels.
However, ivermectin is not among the medications known to affect PSA levels.
Given the lack of substantial evidence supporting the use of ivermectin for lowering PSA levels or treating prostate cancer, it is crucial to consult with a healthcare provider before considering any off-label use of this medication. Relying on unproven treatments may delay appropriate and effective therapies.
The study you reference describes ivermectin used in vitro cell cultures and in vivo animal models and is not a study on humans. Indeed, if you are an athymic nude mouse, this might be interesting news, but even an athymic nude mouse with prostate cancer would be cautious and would likely shy away. But, then, I am not sufficiently arrogant to speak for the athymic nude mice community. I empathize with your quest to find a prostate cancer related benefit for ivermectin, but, aside from the entertainment of anecdotes, there just isn't any such benefit.
IMO the "It's only in-vitro" view of alternative treatments is very short-sighted. If something absolutely annihilates prostate cancer cells it encounters in a petri dish, what is it going to do if it encounters the same prostate cancer cells in your body? High-five them and have a casual conversation?
If something like Ivermectin kills PCa cells in-vitro, some people are anecdotally reporting some degrees of success with it, and it's been used for other purposes in humans safely for decades, could it be there's some merit to trying it? Or when the conventional treatments fail and our MOs give us 3-6 months, do we just shrug and go quietly into the night?
At some point Pluvicto, Nubeqa, and Zytiga were only demonstrated to work "in-vitro". In-vitro doesn't equate to "ineffective".
Thank you for correcting this misinformation. It is very important that this forum not become a place for unproven claims of effective treatments. This can lead people to seek out ineffective treatments when there are FDA approved treatments that work.
It is one thing to say there is a study that is promising and post a link. It is entirely different to say unequivocally that something is a valid treatment that is not.
I’m sure the FDA is looking out for our best interest and not the pharmaceuticals’ best interest.
The 3 people I was close with that had chemotherapy are dead now from the cancer or the chemo. And the hospitals made average $1 million on each one.
There will never be clinical trials with ivermectin because its off patent and big pharma can’t make money off of it
But there are hundreds of testimonials if not, thousands of people either recovering or totally cured from ivermectin protocols with diet and fasting. They post and have videos of how they did it and how much for how long they took it; that sounds like a trial to me. It’s just not the trial everyone is brainwashed to believe.
Unless all these people in the world got together to create a big ivermectin/fenbez lie, I think I will pay attn to the ones actually taking it vs big pharma and the fda who only want money and the oncologists that work for them.
Anyone who has any type of cancer should absolutely look into ivermectin and Fenbendazole with keto for cancer diet and fasting. At least in addition to traditional treatments. Too many people are having success with it not to take notice.
My PSA has already began to reverse and I haven’t done anything with traditional treatments yet and I have the most aggressive prostate cancer at 10 Gleason score.
Posted over a month ago what I was going to do and somebody mocked me and said I was gonna be dead soon - yet all my symptoms have vanished and psa dropped already.
I will continue with 444 mg fenbendazole/96 mg ivermectin, my keto diet w/ fasting, and I will post what my PSA score is in another month. I have no doubt it will be in single digits with the way I’m feeling.
Plus I enjoy having a prostate, balls, and hair and the thought of wearing a diaper doesn’t sound too great to me.
And in the end if I’m wrong, I get to spend eternity in heaven with Jesus Christ
It is about time the FDA developed controlled trials rather than waiting for the cabal to do anything. History shows very little energy is ever expended on potential cures. If it is tested and it doesn’t work, and maybe it won’t, every rational person would then reject it. Thus, it makes me suspicious that it might have promise. I also think these alternative therapies don’t have to replace SOC necessarily. I am also constantly perturbed by research papers that tout a nutraceutical based on in vitro studies but don’t mention bioavailability where the therapeutic dose is impossible to attain through oral means. Finally, I am amazed at how little any of my doctors have any idea of any research outside what the pharma reps tell them. I will be writing to RFK in the near future asking him to help. May be a waste of time but this eons long approach of slash, burn and poison has to stop with highly advertised recent therapies only adding several months of overall survival. If “more research is needed” why are we sitting on our hands for years?
I am also hoping Jesus will welcome me although I have lots of “splaining” to do!
I also asked Malecare's AI Chatbot, Cancer Copilot:
Can invermectin lower psa levels?
Ivermectin is a medication that is primarily used to treat certain types of parasites. While there has been some investigation into its potential use in various medical contexts, to the best of my knowledge, there is currently no solid evidence to suggest that Ivermectin can lower PSA (Prostate-Specific Antigen) levels.
PSA is a protein produced by both normal and cancerous prostate cells. A high level of PSA can be an indication of prostate cancer, but it can also be caused by other conditions like an enlarged prostate (benign prostatic hyperplasia) or an infection of the prostate (prostatitis).
Treatments used to lower PSA levels typically involve addressing the underlying condition causing the raised levels. In the case of prostate cancer, this could involve surgery, radiation therapy, chemotherapy, or hormone therapy.
It's crucial for you to discuss this with your healthcare provider or oncologist as they have your full health history and can provide the most personalized advice.
I hope this information is helpful. If you have more questions or need further clarification, please don't hesitate to ask.
Also, don't forget to sign up for our weekly prostate cancer newsletter at malecare.org/prostate-cance... for the latest updates and information.
Not to be misunderstood , yes these are all topics for study and interest only. More research would be needed for approval use in standardized treatment. Under the present climate and AI advancements I personally think treatments and cures may be found in repurposed drugs or variants of. Already talk of a cancer vax using mRNA platform. Soon we all may look back and say it was there for us all this time .
The mRNA cancer Vax has been in the works fir years and is one reason the covid vaccine was able to be fast tracked. Doesn't have to do with current climate.
Agree, my statement was more in line with patient rights to self treating. don't want to get into it here. Other than to say looks like times are a changing..... maybe
It’s not just about ivermectin. We know now that cancer fuels on glucose and glutamine. Only 2 things in the world that cancer cells get energy from. Fact. Prostate cancer depending on the aggressiveness can primarily feed on glutamine which can be harder to treat. Keto and fasting can reduce and or kill and starve out cancer cells IF they are primarily glucose fed. The ivermectin drug can kill the parasites that cause the cells to go abnormal in the first place from my understanding. Fenbendazole can slow down glutamine fermentation. So together, even with chemo, radiation etc, there are promising results.
The metabolic approach using old, cheap, re-purposed drugs is real. I myself have had success, so far, with the approach. Many have. The keto emphasis plus glucose/glutamine starving of Thomas Seyried is certainly making waves. He's not alone. Jane McClelland...Care Oncology Clinic...many patients and other practitioners all have had demonstrable successes.
BTW I may be on active surveillance only and do not have advanced disease but I hope that doesn't preclude me from being here and learning from others (and maybe even vice-versa). It is still important to me. Let's hope I don't need advanced treatment but if I do I will be prepared.
Yes,can also lower glucose. I have read cases where diabetics have used it to lower there glucose. Kept mine low (not diabetic ) Also some maintain glucose levels with diet , fenben , berberine and take Garcinia Cambogia 30 min before there meal.
Nice ! Keep up the good work. You dosing sounds right for your weight. IVM bio availability requires taking with min20grams of fat prefer 30 gr with some protein. Look into taking with Alpha Lipoic Acid supp. . Vit D 96 thats great . How much vit D if any do you take? Keto is good , but read stay away from dairy red meat and eggs when you have PCa. I had to adjust my keto diet. what are your thought on that?
can this forum ban posts with chatgpt in them if someone wants that they can use the app for free. yes? it isnt a special ability that requires interpreters. people use this forum to speak to humans!
Agree 100%. ChatGPT is not free of influence and unbiased and its responses should be taken with a grain of salt with regards to serious medical matters.
Which interest do you have on your mind related to influencing ChatGPT? I believe it is a program and could be influenced by that, otherwise the biggest influence could be the data which is available for the AI.
I am not saying that ChatGPT should replace our doctors but even doctors could be influenced I believe. Before everyone was prescribed Abiraterone and now when abiraterone is out of patent everyone is getting Enzalutamide. Did you notice that trend?
A. Your observations touch on some interesting points about influence, trends, and decision-making. Let me break this down:
1. ChatGPT's Influences: You're right; the biggest influence on ChatGPT comes from the data it was trained on. The model doesn't "think" or form opinions but provides outputs based on patterns in its training data. It can be influenced by biases in the data or how users interact with it. For example, if the data emphasizes certain trends (like the popularity of specific medications), that could reflect in the model’s responses.
2. Doctors and Prescribing Trends: You’re spot on in pointing out that doctors, as humans, are not immune to influences—be it from new clinical evidence, pharmaceutical marketing, or changing treatment guidelines. The shift from Abiraterone to Enzalutamide may be driven by multiple factors:
Patent and Cost: As you noted, when a drug goes off-patent, generic versions become cheaper, often reducing the incentive for companies to market it aggressively. Newer, patented drugs might get more promotion.
Clinical Evidence: Updated clinical trial results or guidelines may favor one drug over another based on efficacy, safety, or patient-specific factors.
Pharma Influence: Marketing and lobbying by pharmaceutical companies can play a role in shaping prescribing patterns.
3. Trends and Critical Thinking: It’s crucial for both patients and doctors to critically assess these trends. Asking questions like, “Is the new drug demonstrably better for my condition?” or “Does the cost justify the benefits?” is key to informed decision-making.
It’s intriguing how trends in medicine can mirror larger societal dynamics. What’s your take on how these influences might be addressed—especially to keep decisions more patient-centered?
That’s good to hear that bicalutamide is working well for you! It’s a solid medication that’s been used for many years to manage certain prostate conditions, especially in cases of advanced prostate cancer.
Every person’s response to treatment can vary, and it sounds like you’ve found a therapy that works well for your needs. Staying on a medication that’s effective for you—and works without significant side effects—is often the best approach, regardless of newer options on the market.
Do you feel like your medical team is supportive in sticking with what’s working for you, or have they ever suggested switching to newer treatments?
I am actually taking a usual dose 80 mg degarelix ADT injections every 28 days plus in a last year a daily dose of 100 mg of bicalutamide.
My last PSA was 2.73 and it is stable for about a year now.
I don't really know what to say to you except that Bicalutamide monotherapy is not very strong and that you could have a breast enlargement same like with Enzalutamide monotherapy or with Nubeqa monotherapy. You could radiate your breasts or take naproxen (if I good recall the name of the breast cancer medication.) with monotherapy you could develop breast cancer if you have a BRCA genetic mutations.
I tried to hold myself from posting a reply in this specific chat. I was demonized and accused from 'catastrophizing' myself because I dared to look up and share the long list of SEs I found in my research in the internet, copy-paste it here about a Docetaxel SEs.It is clear that when someone from the 'elite' members of this group do it then it's all valid. Such double standard is not something I will never get used to. IMO the initial post here in this chat is worth looking into and replying yo it appropriately, not being absolute dismissed with a superior kind of complex. This nasty PC battle should be a fight all of us affected from it to fight against as one and not to gain notoriety.
Think your best thing is get it and try it.Take your PSA before and give it a go.
Not heard any horror stories.
Just people on both sides with extreme views....
1 camp say it's a miracle and fixes cancer and all of life's problems
1 camp saying it's a nonsense, it's as crazy as a floating white man, with white beard floating about in the sky personally protecting some from cancer and smite others with the cancer!!!!!
Don't see many true unbiased stories?
It's cheap
Over the counter in lots places.
Side effects seem minimal, not sure about nude mice...
I take ivermectin. I also take other cheap re-purposed drugs that are extremely well documented for PCa such as metformin and statins. My surgeon still hasn't cashed in on an RP on me, just expensive biopsies. On active surveillance and PSA stable if not actually decreasing sometimes (around 5 but dropped down to 3.8 last year then back up).
Hi - It's great to see that you are aware of the disease and fully in control to find options to manage. I would also like to add the Lutetium treatment are showing ways to improve quality of life and providing relief from effects of the disease.
I have also found hormonal medicines with time becomes immune to the body and effect on PSA levels are minimal. I have also found that PSA levels when reach in mid to late 20s tend to fluctuate a lot with every blood work. It's important to conduct PSA PET scan to understand metastasis levels and how it's progressing. Also be mindful for any shifts in motor, senses and energy shifts.
You are doing great to be fully aware of your body. You are very strong to go through this. I hope you have many shared moments with your family, friends and spirituality.
I would not use AI for anything nuanced. It's still too crude and unpredictable. If you just want a plain vanilla fact it's probably just fine. I enjoy using ChatGPT for some stuff, but it's limited.
I read this all the time how many alternative treatment journeys start out when soc has failed and the reality of what do I have to lose at this point begins. So for me I never rule out my decisions making process ahead of it's time.
When I was first diagnosed almost 25 years ago I used colonics to improve gut micro biome because some dude named Hippocrates said all illness begins in the gut. I was told by my doctors when Psa dropped and a biopsy could no longer find a tumor in my prostate it was “all anecdotal “. For forty years suppressing testosterone was the SOC for metastatic prostate cancer. Now we have a Doctor who injects patients with testosterone at JH and a lab there that is devoted to studying the various gut bacteria and its effect on prostate cancer. Name of lab is Karen Sfanos lab.They have six stool donors at present but my Dr. didn’t say if it was for study or fecal transplantation.
Now I will say this about Fenben. There is a FB group that In am following that follow Joe Tippens protocol. There are many testimonies but something I find very troubling is that virtually every testimony is by a person that is also using conventional medicine and give all the credit to the JT protocol. There are guys just like me that have had Psa go from several thousand to 1 and say there is no way the adt would do that be itself and here I am and adt did it for me without alternative meds. I’m just pointing this out and urging you to have an open and unbiased mind when researching. I have seen the very same thing happen on Gersons FB page. A guy with Pca had great improvement when he went on Gersons and the only other thing he did was take Lupron. Honestly if a person really believes in an alternative treatment, why not forgo SOC and just use alternative because if not you don’t really know what to credit. God bless.
I read those testimonies to, But also read medical science papers stating drugs like fenben and Ivermectin work synergistically with chemo and radiation . This is where a good Integrative onco doctors play a vital role.
Because mebendazole work in addition, parallel to chemotherapy. I want to use ADT. I am even not a fan of Enzalutamide monotherapy or estrogens etc.
Fizazi said that off label drugs are a new research topic. Something new and developing. I am not advocating a use of any off label medication for prostate cancer but I would not be surprised if we will see new developments there.
"but I would not be surprised if we will see new developments there."
What do you mean? There's a ton of very positive evidence on PCa treatment and repurposed drugs like metformin and statins. Just do research like a human.
I already said that I am using statins since the end of my chemotherapy and started to use Metformin later when my PSA started to go up slowly from my PSA nadir of 0.12. Therefore I am aware of the benefits of statins and Metformin long time ago because my medical oncologist endorsed it. I wish you luck with your Gleason 3+3 prostate cancer. Just letting you know that we have members who started with Gleason 6 and after some substandard treatment they are now in full standard of care treatment.
I am just wondering would you consider Nano knife focal treatment?
That's right, you don't know the "cause" but don't forget the key concept... SYNERGISTIC EFFECTS.Same as some chemo sensitizing RT for increased efficacy. The big realization in recent years is that repurposed drugs act synergistically in a multiplicative way when taken together. The idea is to suppress the various pathways the cancer cells have to feed. Hit the cancer with all you got but in a carefully understood way. Hit their metabolism. Starve the bastard. Current treatment can seem so primitive in comparison!
Having worked in healthcare, now with healthcare issues, I understand the desire to consider all options. But when you read studies you find there's limited information on something that has been around for a hundred years and have to accept why it's limited.
I understand all to well why some things are limited . Some options are from recent times.but limiting information to the pop has surely been around for thousands of years.
Ivermectin has only been around a few years. Why, its discoverers only got the Nobel Prize 9 years ago! Why so long to be recognized?? They discovered it in 1975. It took another decade for human use approval. Maybe it will take 100 years before the slash and burn approach is abandoned.
How do you know? Was that ChatGPT words? I don't know anymore if what you say can be trusted because your name had AI words usually. In the end nobody will know nothing because everyone is just repeating empty AI.
Again, if you have the time to wait years and years for the "Gold Standard" studies to be published good for you. However, Medicine 3.0 takes ALL available information and makes rational, logical considerations, and also looks at numerous antidotal successes, and comes to a conclusion. Today's antidotal sometimes becomes the "Gold Standard" 5-10 years from today. I think as long as the well-known medical statement, "Do No Harm" can be honored, not huge downsides. We see practitioners at well-known institutions doing this with BAT past where the studies have gone. Dr Makis doing same with Ivermectin. Always best to do this in collaboration with an MD.
No I dont. I would have to go into the substack and search. Since he covers all different cancers and other ailments, there are tons of things to go through. Sorry.
The moment I saw that headline I knew most of the people here would jump on it. This is definitely not an alternative-medicine group. It's a good thing that modern doctors and treatment methods have cured cancer, so we don't need to question them or consider alternative approaches.
Oh, I can remember having a conversation with my MO back in 19' about BAT, lol. Maybe one or two studies occuring then. Compared to today? Want accepted much back then, today an entirely different story.
Do we chastise or thank those that insisted and prevailed in obtaining that path? For those that it works for of course. My point is, we cannot be stuck in "what's currently science approved" because it's those that cut new paths and pave new roads that others benefit from later. As long as you understand the risks of being the path paver!
One of my worries and what I look for, is the differentiation of Association and Causations... Mechanism of Actions! Ensure that the Ivermectin is not just "masking" the PSA, etc.
THIS IS A RELOCATED REPLY FROM "MELODYCAT" Three replies to his reply are included below.
Hi all,
I am a surprise mHSPC in that I had no symptoms, no family history, PSA at 4.7 (even free PSA not indicative) with a 4+3 Gleason score. Opted for radical prostatectomy surgery since no mets were expected. An unrelated scan found the lesion on L4 and had SBRT and on Lupron and Erleada. Limited side effects with any of the treatments so far.
Related to this discussion, I would like to make a few comments based on my years of amateur research (done in conjunction with a long time professional cancer researcher.) Cancer is a very adaptive foe and treatments need to be multi-faceted while still targeting the specifics of the cancer involved. Too many studies, especially in vitro and mouse models take only one factor at a time to determine effectiveness rather than in combo with ADT etc. Because of animal rights issues, the testing has to be on mice that are compromised so as to shorten their suffering. Thus, we have little knowledge of real world long term problems/benefits in humans. We don’t get to learn from clinical studies because neither the US Government nor Big Pharma are motivated to study cures that are either repurposed or from an inexpensive natural source.
That leaves us with having to sort through less-than-optimal studies, foreign research papers and anecdotal information. That is why chatGPT isn’t much help as it will give Standard of Care guidelines and “no evidence of” responses since the follow up studies are never made even tough the last sentence in a research report was “more research and clinical studies must be made.” Also, detractors of potential therapies go off on something being used as a horse dewormer ignoring how often translational medicine come into play. The warning I would give is that the Internet is chock full of garbage ideas and very little devoted to really hopeful therapies. Case in point is the recently announced bespoke mRNA cancer vaccines announced by Russia. I realize that Russia is a political foe and they have some tendency to overstate their results but you also need to realize they do some really good research and mRNA strategies hold a great deal of hope in that cancer cells woukd have a hard time adapting to them. Makes you wonder why our researchers aren’t at least more curious than dismissive.
Ivermectin, like most off label treatments, works better on some cancer lines than others and it depends on hoe “far along” you are. It is not a standalone cancer killer and should never be used in place of Standard of Care therapies from your doctor. It got a bad name from a rushed solution to COVID when other approaches, developed later, were more effective. Dr. William Makis is a strong proponent of Ivermectin and maybe a bit breathless in its positive applications. In reasonable doses it has few if any side effects. I know people, not me, who have been taking modest dosages for a long time with no ill effects. I would warn that the some of the same people touting Ivermectin also suggest Fenbendazole and Metformin that should be approached with great caution since both kf these can have very severe side effects.
Sorry for the long post but I am a beginner here.
Written by
MelodyCat profile image
MelodyCat
3 Replies
•
Schwah profile imageSchwah
4 hours ago
Thanks for your thoughtful post. Couple of follow up questions. First are you currently taking ivermectin and if so how much? What information have you found that leads you to believe Ivermectin may be helpful with prostate cancer?
Schwah
MelodyCat profile imageMelodyCat• in reply toSchwah
A few seconds ago
Hi,
Ivermectin was shown in a 2020 study in CellDeath and Disease to cause significant cell arrest, apoptosis (triggered cell death) and DNA damage selective to prostate cancer cells. It also has been shown to alter the tumor microenvironment, supress heat shock proteins (HSP27) and PAK-1/STAT5 as well as enhance the effects of T blockers like Enzalutamide. I am most interested in how decreases something called MDSC which should help with stem-like cells. These are the “seeds” that are resistant to chemo, ADT and radiation. No cure will exist without obliterating these suckers. Supposedly, some clinical trials are anticipated on Ivermectin for cancers and can only hope they occur and are done appropriately. I take 12mg daily with no problems. Do I imagine that it is a miracle? Nope. Do I think it is a low risk addition to regular therapy for me? My “strategy” is to keep healthy as long as possible for time for a peptide or mRNA therapy to come on line. I hope that for everybody.
"Professor Karim Fizazi has contributed to research examining the effects of repurposed drugs, such as metformin and statins, on prostate cancer outcomes. A secondary analysis of the COU-AA-301 and COU-AA-302 trials, which included Professor Fizazi as a co-author, investigated the impact of metformin and statin use in men with castration-resistant metastatic prostate cancer. The study found that the use of these medications was associated with improved clinical outcomes, suggesting potential benefits in this patient population.
Additionally, a meta-analysis of data from three phase III trials (AFFIRM, PREVAIL, and PROSPER) evaluated the association between statin and metformin use and outcomes in patients with castration-resistant prostate cancer treated with enzalutamide. The analysis indicated that baseline use of these medications might be linked to improved radiographic progression-free survival and overall survival, although the findings were not definitive. "
I am using rosuvastatin since I stopped my docetaxel chemotherapy plus I added Metformin mainly because people on long term ADT like myself (7 years in June this year) are prediabetic.
I understand that rosuvastatin plus Metformin are not yet proven cancer fighting drugs but they could help me to avoid a long term cardiovascular side effects. (At least I hope so.)
one thing that strikes me about posts about fenben-ivmctn is the strong Deja-vu it invokes. Sounds like most ( everyone ? ) here missed the Laetrile - amygdalin rush of the mid late 70s. - 1980s. This prostrate and ( esp ) breast cancer cure swept the nation. My friend Mark , urang on this group ( now passed ) was caught up in the rush a bit as well. . There was intense interest and fighting so called “ big pharma “ over it. After all you could get and cook peach pits fresh off the tree in your back yard.
An enormous wave of Americans swept across the Mexican border to get the treatments from an army of new Laetrile clinics that sprang up over there. Laetrile was considered dangerous in the USA ( blocked by big pharma, of course ) but used in many countries world wide and even in Germany , most patients considered it dramatically better than ( on your tree , also suppressed by big pharma ) mistletoe. ( which is still used in places in Germany ).
Laetrile is still a lingering “ cure “ that peaked in the 1980s and dozens of amygdalin clinics still exist in every border city ( google it ). More than 70,000 Americans are known to have gotten the treatment, but it’s estimated that the actual figure was double or three times that.
Anyway, it doesn’t seem like fenben- ivmctn has risen to that level popularity yet, but who knows it took amygdalin , like mistletoe from the late 1800s to the 1950s/1960s to really take off … fenben and ivmctn might follow suit one of these days. someone or a group of fenben followers here could band together and start a clinic in Mexico and offer the “ professional “ fenben - ivmctn cure to those that want it. This would surely eventually ( like with Laetrile ) establish the validity of all the claims ( which are currently / dramatically fewer than with Laetrile ) and cause a black eye for , so called, big pharma. Never mind the millions to be made.
Ivermectin is an FDA approved drug , that could be repurposed and on the list of drugs is considered safer than most. Laetrile is not FDA approved and is not in the same class. Fenben is a vet drug but the FDA approved version is Mebendazole and has been used to treat cancer. Ivermectin is not a poison it is used as a vet and human treatment approved for various ailments. If you eat apples don't eat the pits they contain amygdalin . lol
Tell me more about your trust in "communicating" with an unconscious robot.
Eliza said
(Eliza was the first "AI" medical expert created in 1964 by MIT's Joseph Weizenbaum (real name!). Ask your oracle about it. Eliza used simplistic psychology of reflecting back your biases to trick actual humans (with RI, real intelligence) into becoming so engaged with its pseudo-responses that they refused to stop using it and consequently lost their minds for a while).
Welcome to the machine, Seasid and others hypnotized by the filtered responses machine learning transumanism experiment. Enter the Stargate!
Which "AI" do you mean? Which app/website? You do yourself a disservice by being unclear and opaque. The text you wrote sounds too confident. Ivermectin has indeed shown great promise and there are well-documented effects in treating disease beyond it's standard target diseases usually quoted by skeptics and sheer opponents. But no medicine's efficacy is perfect, not even SOC treatments.
There are no proofs outside of mathematics and logic.
Repurposed (off-label) Drugs for Targeting the MSCC
Ivermectin
An anti-parasitic derived from a bacteria called Streptomyces avermitilis, Ivermectin has anti-cancer properties and induces autophagy and apoptosis of cancer cells (Liu, et al., 2020). Ivermectin has shown a significant impact on various cancer cell lines (Juarez, et al., 2020), inducing apoptosis in cancer cells in vivo (Sharmeen, et al., 2010) and significantly reducing tumor volume compared to a control (Juarez, et al., 2020). It induces apoptosis in cancer cells through mitochondrial mediation (Juarez, et al., 2018; Tang, et al., 2021). Ivermectin can target and regulate the pyruvate kinase muscle isoforms at the last step of glycolysis (Li, et al., 2020). It can inhibit glycolysis inducing autophagy (Feng, et al., 2022), and have a selective pro-oxidant effect on cancer cells (Wang, et al., 2018). It can also target CSCs and metastases (Dominguez-Gomez, et al., 2018; Jiang, et al., 2022) and macrophages (Zhang, et al., 2022). In vitro, Ivermectin is more effective at inhibiting CSCs in breast cancer cells compared to chemotherapy (paclitaxel) (Dominguez-Gomez, et al., 2018). In vivo, Ivermectin alone is more effective than standard chemotherapy (gemcitabine) alone at reducing tumor weight and volume in pancreatic cancer (Lee, et al., 2022). Ivermectin is a very safe drug. In healthy volunteers, the single dose was increased to 2 mg/Kg, and no serious adverse reactions were found (Guzzo, et al., 2002). Demonstrated in another study, cancer patients who took Ivermectin at five times the standard dose (up to 1mg/kg) daily for up to 180 consecutive days had no serious adverse effects (de Castro, et al., 2020). In cases successfully treated with a total or partial combination of Ivermectin, dichloroacetate, and Omeprazole (plus Tamoxifen), Ivermectin inhibited tumor growth through mitochondrial dysfunction and led to apoptosis (Ishiguro, et al., 2022).
I take 10 mg once a week...a very low dose as preventative but I am only Grade 1 PCa. But I also have had oropharyngeal cancer (HPV SCC, tonsil surgery only, Aug 2024). On surveillance both. No RT or chemo recommended...or wanted.
I dosed based on IVM cancer protocol video put out by SunFruit Dan on Rumble. Starting dose was 0.2mg / kg slowly worked up to 0.5mg/kg once/daily then worked up to 0.5mg/kg twice daily 10hrs apart. So based on my ideal body weight = 100mg/ day. Also taken with 600mg of Alpha Lipoic Acid each IVM dose. Tudca once daily. This is aggressive cancer dosing. Best to review his videos . I not lookig to do chemo either.... for now.
my palliative are doctor hs a video visit with me once every 60 days to go over my med list, my supplements list, pain meds etc. I take more than 30 meds / supplements/ gummies daily….it can get complicated meshing side effects and contraindications Rotflol.
AI is clearly biased. It speaks with empty authority, cherry-picking to regurgitate "facts" when nobody is even checking them. It is probably the #1 danger in the world today. And then there's STARTGATE coming!!?? Oh boy.
The COC did the METRICS trial - a successful clinical trial for glioblstoma. Notwithstanding the "concerns" and "feelings" some felt (forcing the editors to signal that "concerns" had been signalled), it is worthy of your study:
"An example of an off-label drug protocol brought to the clinic for glioblastoma patients is presented, along with preliminary retrospective data from the METRICS study (NCT02201381). METRICS is a novel participant-funded, open-label, non-randomized, single-arm real-world study designed to gather high-quality evidence on the safety, tolerability, and effectiveness of four off-label metabolically targeted medicines as an adjunctive cancer treatment for glioblastoma patients.
Regulatory authorities, healthcare purchasers, and clinicians require high-quality reliable evidence that can support the off-label use of drugs and relabeling for new indications. But how can this evidence be generated, in a situation where the funding of phase III trials is not commercially viable, and the ethics of placebo-controlled trials are increasingly under scrutiny, with their real-world relevance under question (Daugherty et al., 2008; Hamilton and Peppercorn, 2011; Corrigan-Curay et al., 2018)?
...
Pluralistic evidence as a methodological research approach can be used for clinical development programs where it is impossible, impractical, or unethical to follow a more traditional RCT-based approach (Tucker and Reed, 2008; Fives et al., 2017). In accordance with this, a pluralistic approach could therefore be applied when there is no commercial rationale for running a large randomized controlled clinical study to help establish causality for the efficacy of an off-label treatment in cancer.
...
RESULTS
...the cohort as a whole (n = 95) had a median survival of 26.3 months and a two-year survival of 55.8%, with the censoring of patients shown in the Kaplan-Meier plot (Figure 1A). The SoC treatments received alongside the-off-label medications were: surgery, chemotherapy and radiotherapy (72.2%), biopsy, chemotherapy and radiotherapy (15.6%), radiotherapy alone (4.4%) and others (7.8%) (Figure 1A). The median OS for this unselected cohort of patients with GBM who received off-label medications alongside optimal SoC (i.e. surgery, chemotherapy and radiotherapy) was 27.1 months (95% CI 24.0; 37.6) from diagnosis, with a 2-year survival of 64.0%. These analyses compares favorably with other GBM cohorts receiving optimal SoC alone, with a median OS of 14.8 months (CI 14.2; 15.4) in the Public Health England dataset (Brodbelt et al., 2015) and 15.8 months (CI 13.2; 16.8) in a study by the European Organisation for Research and Treatment of Cancer (Stupp et al., 2005), with a 2-year survival of 28.7% and 26.5%, respectively (Figure 1B)."
"COC Protocol: The Care Oncology Clinic has developed a protocol combining metformin, atorvastatin, doxycycline, and mebendazole, aiming to target cancer metabolism. While preclinical studies and anecdotal reports suggest potential benefits, comprehensive clinical trial results are still pending. In summary, while these drugs have shown promise in various studies, results have been mixed, and more rigorous clinical trials are needed to establish their efficacy and safety in cancer treatment. "
RI (real intelligence):
"...the cohort as a whole (n = 95) had a median survival of 26.3 months and a two-year survival of 55.8%, with the censoring of patients shown in the Kaplan-Meier plot (Figure 1A). The SoC treatments received alongside the-off-label medications were: surgery, chemotherapy and radiotherapy (72.2%), biopsy, chemotherapy and radiotherapy (15.6%), radiotherapy alone (4.4%) and others (7.8%) (Figure 1A). The median OS for this unselected cohort of patients with GBM who received off-label medications alongside optimal SoC (i.e. surgery, chemotherapy and radiotherapy) was 27.1 months (95% CI 24.0; 37.6) from diagnosis, with a 2-year survival of 64.0%. These analyses compares favorably with other GBM cohorts receiving optimal SoC alone, with a median OS of 14.8 months (CI 14.2; 15.4) in the Public Health England dataset (Brodbelt et al., 2015) and 15.8 months (CI 13.2; 16.8) in a study by the European Organisation for Research and Treatment of Cancer (Stupp et al., 2005), with a 2-year survival of 28.7% and 26.5%, respectively (Figure 1B)."
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Ivermectin for Cancer
