On ronrons advice and experience I decided to give estrogen replacement a try. I get horrible hot flashes every hour that leaves me drenched in sweat. I stopped taking lupron 6mo ago hoping that was the biggest culprit.
Last blood test still showsT <12. I take 500mg of zytiga and 5mg of prednisone. Ironically, I had my first psa rise from .6 to 2.7 the last 6 weeks, ~20 week mark.
I use 2 pumps, 1.5mg of estrogen per day. Been on for 2 weeks along with Zytiga. No noticeable changes in hot flashes. I have to pay $170us out of pocket for this stuff so curious about other ppls experience before I continue. Did it help with hot flashes? How long did it take before you saw a change in symptoms?
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thank you. Yes it's been maddening to put it lightly. I'll literally try anything, QOL has been terrible. I'm absolutely dreading the winter coming up. The sweat is like stepping out of the shower in your clothes. I'm soo jealous and happy for you.
WOW...$170! I'm trying to do a comparision between your gel and what I'm using. I don't see a % on my tubes? I can sell my gel for $25/tube if we can figure out how they compare?
I'm so sorry to hear that what you're using isn't working for you. I have only used this gel when my PSA rose above .71...nothing else.
Regarding smurtaw's post below: I am applying the gel twice daily which is giving me about 2.5 mg of E2 per day. I can't imagine why the patches would be anymore effective?
My MO gave me low dose Paxil - 20 mg for the hot flashes. It's working for me and low enough dose that we are not worried about withdrawal systems when I stop.
I'm 30 days into using Estradiol 0.1% gel using one sachet per day. The drenching sweats have stopped and flashes are now "warm" and less frequent (were very 90 minutes or so and now 4 hours). It didn't happen immediately but improved over time.
I did not, but one letter to my insurance from the MO got it approved. I did have to stomp my feet a little though. I don’t think they truly appreciate how debilitating these side effects can be for some. Good luck!
Which gel patch or oral med deserves close study - cardiovasc risk is high ( see pubmed)
One may try avoiding caffeine, hot or cold liquid intake, and changes in external temps. Some of the antidepressants and anxiety drugs, as well as, pain meds will cause sweating, and so will the various ADT formulas.
You should see results in two weeks if absorbed dose is adequate. Nipple tenderness could indicate you are getting enough E2, short of a blood level test. I used generic patches, Dotti, 0.10 mg/24 hrs. Worked very well for stopping hot flushes and made me feel more energetic and clear headed while on ADT.
I currently use Orgovyx for the ADT periods of my mBAT program as I can start and stop it more quickly. Not currently having hot flushes while on that for some unknown reason.
I just saw my oncologist, Dr. A. Sartor, for a 6 month visit. I had been taking Androgel for about 1.5 years after being below castrate level for 7 years and he felt I was debilitated because of no t. I began and the T was usually about 120-130 ng/dl. PSA began rising and when it hit 3.16 I stopped the Androgel. T went it 11ng/dl and PSA began decreasing by 1/2 every two months. But I had never had hot flashes like this before. Just brutal. He proscribed Oxybutynin Chloride 5 mg twice daily. and haven’t had a single hot flash since ( about 2 months ago). It is off label as it is normally prescribed for bladder spams. It certainly worked wonders for me.
I will definitely look into this. I feel like I tried everything and I don’t have any confidence that my medical team has taken it seriously enough. If I’m told one more time that it’s like a woman going through menopause and your body will eventually adjust I’m going to scream. It’s more than apparent two years in that I’m experiencing the extreme case when it comes to hot flushes. In my case, hot flashes above and beyond any other side affect is what affects my QOL the most. I pray no-one else is dealing with this to this level.
I'm taking MedroxyProgesteron TB 10mg twice a day and the hot flashes are 95% gone.
Hey guy! I followed Ron Ron and got a tube of gel a year back . I started applying it to my thigh twice daily .. But by the time I had finished my first tube my tits swelled and the nips became super sore and painful . I dropped it . It wasn’t for me at the time . So much for self medicating? Good luck .
From A to C . Really sensitive and painful which I didn’t have prior . Not for me .. However I’d Try anything . N= 1 .. we don’t know until we try . ✌️
I’m happy to report that I’m finally getting relief from hot flashes using the gel. Took about 2 weeks for me at 2 pumps a day. I also finally got insurance to cover it. This is a great day!!!
(So far no nipple soreness, chest is still rock solid, MO was 100% supportive, didn’t have to sell him at all) If I ever have real money, I’m donating to this website. This group has been an invaluable source of dialogue. Thank you from the bottom of my heart.
Trying to get my regular MO on board with topical estrogen while on Lupron. Funny I get the same replies, could cause blood clots. Even when I mention alternate delivery method and effects. Have there been any studies done regarding topical application, QOL dose?
My mo said the same when I brought it up, but did not dismiss it and Cleary did some research because he prescribed it with very little pushback. My suspicion is insurance plays a big part in it, as anything that is outside of SOC is work to get paid on. Drs aren’t looking for more work. IMO, if your MO doesn’t want to consider this for you, it’s time to change oncologist.
With Smutaw's help, I'll see what he says. I kind of agree with you. I think he will do it, wished to see documents regarding recommended dose. It is kind of interesting. This behavior reeks of inattentiveness.
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