Trelstar and Xofigo

[Altamontt]

Has anyone used this combination? My oncologist is thinking of this. I'm th liking of Pluvito. Had PMSA scan that showed multiple Mets on spine , ribs, pelvis and femurs.

[tango65]

Do you know the SUV values of the mets? Did you get a FDG PET/CT. ?

If the SUV values of the mets are below the SUV value of the liver the response to Lu 177 PSMA treatment will not be optimal.

Have you discuss having a biopsy of the mets?

[cesces in reply to tango65]

what's an SUV value?

[tango65 in reply to cesces]

Standard uptake value.

[dhccpa in reply to tango65]

is FDG PET also known as a PET bone scan?

[Spyder54 in reply to tango65]

Tango, dont know where you get your info, but you are always on it Man. Thank you.

I just re read my Pylarify Scan Notes, and there is no mention of SUV in Liver, only the 3 Lymph mets they found. SUV of 6,12,17. So cannot compare to Liver?

Mike

[tango65 in reply to Spyder54]

12 and 17 are above the SUV of the liver which usually has a SUV around 7 to 9. I believe you could have qualified for the Vision trial.

Best of luck with the Lu 177 PSMA treatment.

[meowlicious99 in reply to Spyder54]

This video explains PSMA and LU

youtube.com/watch?v=JoJomAC...(Not working as expected?)

[cesces]

Trelstar

I've not heard of Trelstar.

What advantages or disadvantages, including price, does it have compared to other agonists?

[dhccpa in reply to cesces]

same as Lupron or Eligard

[EB6653497 in reply to dhccpa]

it was explained to be newer option. Same results but half the medication of Lupron and Eligard. Therefor not as much to process with side effects. And Lupron was in short supply over the last 2 years.

[dhccpa in reply to EB6653497]

It's possible, but I wasn't told that. My first shot was Trelstar four years ago, but by next shot I had moved over to a different institution in a different city, which used Lupron. My understanding at the time is that they were essentially identical (as opposed, say, to Lupron vs Firmagan), and that each institution tended to align themselves with one drug or the other, for whatever reason. But I certainly didn't drill down on that at the time. Along the way, when there was a Lupron shortage in 2020, I got 4-5 Eligard shots, then went back to Lupron in 2021. I haven't noticed any difference in side effects, but most of that four years I've had Lupron.

[Seasid]

What was your PSA at the time of the PSMA PET scan?

Do you have bone pain?

[Altamontt in reply to Seasid]

PSA was 4.5. I have some pain in hips and spine. Been Advil Dual makes that manageable.

[Seasid in reply to Altamontt]

are you on bone strengthening medication?

[Altamontt in reply to Seasid]

xgeva

[Seasid in reply to Altamontt]

that is very important if you want to do Xofigo. My medical oncologist said that Xofigo is only indicated for bone pain paliation but it will not fight prostate cancer. Chemotherapy would be better or if you have only pain at one site than maybe that site could be radiated if the chemo will not help with your pain.

You could save Xofigo for the future. It can break bones if you are unlucky. I am not a doctor nor i am in a position to see everything but i wouldn't jump into Xofigo if I could solve the limited bone pain by other means. Xofigo is not risk free.

[Seasid]

just letting you know that your profile is empty. It would help if you could fil it out.

[Seasid]

you can only receive 6 Pluvicto infusions in your lifetime because of the radiation.

If you would fill out your profile better maybe we could advise you better. It is very risky to say anything if we don't have your full information. Pluvicto is usually given if your life expectancy is under 8 to 10 years. We don't know your age etc.

[MateoBeach]

a bone strengthening program with either Xgeva or Zometa will help reduce risk of adverse skeletal events (fractures etc). Combining with celecoxib May improve progression free survival.

PSMA PET scan can show if Pluvicto can be of benefit vs Xofigo now. With either of these try to get Provenge along with either Pluvicto or Xofigo for enhanced immunologic response.

These are just some ideas to consider and discuss with your oncologist. Not prescribing. Details of your status must be all considered.