I'm curious about the opinions of members here on how they would currently rank Neutraceutical and off-label use drugs in order of highest benefit potential (most confirming clinical trial evidence combined with actual therapeutic or synergistic therapeutic effect) in slowing/stopping PCa progression?
I cannot yet speak from long-time actual experience (even still it's hard to pinpoint what works and what doesn't if you are doing multiple things at once) but based on lots of reading here on this forum and on Pubmed, etc., I would venture to guess:
1) Plant-based diet (or very close to it) combined with exercise - maybe not technically a neutraceutical but I would feel negligent if I didn't include it. (Most likely more significant as a preventative measure than in an intervention phase - but basically a no brainer in my opinion.)
2) Statin combined with blood glucose lowering Berberine or Metformin (No high-quality evidence Berberine or Metformin has significant benefit alone.)
3) Statin alone
4) Sulforaphane (free stabilized or Glucoraphanin with active Myrosinase) - weak on clinical study data but sounds very promising from a biochemistry point of view and initial studies sound like it may be worthwhile (the UK Broccoli soup study and the French Study using 60mg Prostaphane)
5) Modified Citrus Pectin (MCP - Pectasol)
The above 5 I personally feel are most significant. The remaining I think have weaker/conflicting evidence or no evidence of positive benefit on slowing PCa progression.
8) Lycopene (only in form of tomato concentrated products - paste or sauce, not supplements or raw tomatoes.)
9) Acetyl L-Carnitine
10) EGCG (Grean tea catechin)
11) Vitamin D2
Neutraceuticals to AVOID?
2) Vitamin E
3) Vitamin B-12
Interactions with pharmaceuticals/treatments to be wary of (other than don't take antioxidants during radiotherapy)????
For those new on the Neutraceutical Research Wagon, this is a pretty good summary although not necessarily cutting edge up to date as I'm sure there's quite a vetting process before the NIH adds new info to this PDQ.
Is there any other 3rd party or Oncologist that has published their own Neutraceutical PDQ based on the very latest cutting-edge research? Or other than the NCI PDQ are we left to piecing together Pubmed Articles with Forum Posts?
The other big question is, in general, if you are combining too many antioxidants and/or anti-inflammatories, can the combination essentially backfire and HELP the cancer progress? Wish I would have majored in Biochemistry at this point. I do know Pro Vitamina A Antioxidants (like Vitamin E and Vitamin A) have been shown to promote cancer. But each substance can have different biochemical mechanisms.
Some of these substances have been shown to lower Testosterone/ADT, or AR binding. So another question is do nutraceuticals that have a mild ADT-like effect essentially accelerate the cancer to become castration-resistant like ADT but just to a slower degree?
This study I found particularly interesting as they seem to just throw everything at the wall and see what stuck - nothing. (Also seems to contradict other studies regarding Sulforphane.)
The overall pattern I'm seeing is that Prostate cancer is essentially fueled by Testosterone/DHT and Lipids. So anything that lowers either of those has the most potential to slow the progression. But as we know, at least on the former, the cancer eventually mutates so it can progress without that particular fuel.