Clinical trial using Enzalutamide and Cisplatin

[Newyork6264]

My oncologist has suggested a clinical trial involving Enzalutamide and Cisplatin. Right now I am on Lynparza and my PSA has started to rise. Does anyone have any experience or information on this trial?

[Hidden]

Possibly this one?

clinicaltrials.gov/ct2/show...

[Newyork6264 in reply to Hidden]

I think so. Roswell and U of R is where I have gotten treatment. Looks like it’s just a phase 1.

[Hidden in reply to Newyork6264]

Seems to me that it would be better to go with proven chemotherapy treatments Docetaxel or Cabazitaxel with the possibility of adding a platinum chemo if indicated rather than a single platinum chemo, especially one that generally has tougher side effects. My understanding is Cisplatin is a tougher chemotherapy than Carboplatin.

[Hidden]

Since it looks like you've already had chemotherapy, the results of this clinical trial might interest you:

nejm.org/doi/full/10.1056/n...

[Newyork6264 in reply to Hidden]

I’ll look into it. Thanks for all the help.

[CAMPSOUPS in reply to Hidden]

Thanks. Verifies the approaches we see lately. The Card trial.

[Hidden]

I have been using Olaparib since May 2020, PSA was 0.46. - now 0.15. Biallelic BRCA2. I am discussing with the MD using Ponatinib when PSA starts to rise, please see nature.com/articles/s41467-... does not work well when the effect of a PARPi no longer works.

[Newyork6264]

Presently my wife has endometrial cancer. Would you have any related showing links related to its use forendometrial cancer.