Zytiga clinical trial: Has there been a... - Advanced Prostate...

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Zytiga clinical trial

Advo__cate profile image
10 Replies

Has there been a clinical trial for Zytiga without the inclusion of Prednisone? If not, how do they conclude Zytiga 'must be taken' with prednisone?

My husband has not been on the prednisone while taking Zytiga and his labs (every 6 wks - 3 months) have been completely normal. Potassium remains in the high-normal range. Blood pressure remains in normal range. No fluid retention.

Just wondering.

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Advo__cate
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10 Replies
Tall_Allen profile image
Tall_Allen

They concluded that based on the fact that Zytiga also shuts down cortisol production by the adrenals. It is a very low dose and is meant as a replacement dose only - if the dose is right, it should not have any side effects. Watch for edema.

Advo__cate profile image
Advo__cate in reply to Tall_Allen

watching for it all. It's in his 'tool box' to start up at any time. He is under observation.

Tall_Allen profile image
Tall_Allen in reply to Advo__cate

Cortisol has wide ranging effects :

en.wikipedia.org/wiki/Cortisol

Low cortisol levels cause many long-term problems, and causes an accumulation of ACTH.

tango65 profile image
tango65

Is he taking eplenerone (Inspra)?. Inspra is an aldestorene receptor blocker and it may help to control the effects caused by the increase of aldosterone when taking Zytiga.

Advo__cate profile image
Advo__cate in reply to tango65

No, need to look that up.

Advo__cate profile image
Advo__cate in reply to tango65

Actually, he was put on that for about two days when he was in the midst of cardiac issues a couple of months ago. It gve him a debilitatating headache so he dropped it and switched to amlodipine instead.

NPfisherman profile image
NPfisherman

It is necessary for prevention of adrenocortical insufficiency:

sciencedirect.com/topics/ne...

Prednisone can cause an increased potassium--don't worry about that high normal potassium... Hope it is working well for him.....

Fish

Advo__cate profile image
Advo__cate in reply to NPfisherman

Potassium is in normal ranges, MO is pleased with the labs.

GP24 profile image
GP24

You can use Dexamethasone instead of Prednisone. This trial reports better results with Dexamethasone:

sciencedirect.com/science/a...

theoncologist.alphamedpress...

Advo__cate profile image
Advo__cate in reply to GP24

Thanks for the info...much appreciated.

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