Clinical trial ODM-201: Has anyone had... - Advanced Prostate...

Advanced Prostate Cancer

22,290 members27,988 posts

Clinical trial ODM-201

Bobkar profile image
16 Replies

Has anyone had any experience with ODM-201 clinical trial . My brother is to start this week. Have read all the info but it’s nice to hear from someone who has first hand experience.

Written by
Bobkar profile image
Bobkar
To view profiles and participate in discussions please or .
Read more about...
16 Replies

Hi:

I do not have experience with this drug and/or the trial i just wonder why is he going to a placebo trial when the FDA just approved apalutamide an anti androgen which offers a survival advantage. Just curious. Did he fail enzalutamide and/or apalutamide?

Bobkar profile image
Bobkar in reply to

No he has had no treatment yet except lupron shot and casidex.I will call and ask about this. He just had first appt Friday at Moffitt cancer center and it was so overwhelming and we are just grasping for any hope. Thank you will call and ask this question.have not signed any papers yet. As I understand it,he will get all the standard treatment but this pill can also extend his life. double blind trial that he has 50% chance of getting the pill .

Cynthgob profile image
Cynthgob in reply toBobkar

My husband is in the trial. Same treatment as your brother. He’s just finishing chemo tomorrow. We picked this trial as we thought it was the best choice. He’s a Gleason score of 8 and many many bone mets. He’s finally out of pain and seems to have managed to get through the chemo . Hair loss and damaged nails . But he’s still standing.Had lupron and casidex as well.

Bobkar profile image
Bobkar in reply toCynthgob

My brothers Gleason score is 8 also with the bone Mets. Your husband is giving me some hope! Did you ice the fingernails before or after chemo? Pray your husband continues his path. Please keep me updated. Thank you

Cynthgob profile image
Cynthgob in reply toBobkar

No we didn’t as it didn’t start until the end. Will ask today and see what they say. We are on sixth chemo today . Just praying all goes well

Bobkar profile image
Bobkar in reply toCynthgob

Praying

Bobkar profile image
Bobkar in reply toCynthgob

How is your husband doing, my brother is waiting for the paperwork to sign for the trial and then more scans, blood work, chemo is delayed about 5-6 was until the trial pills are taken. Getting anxious seems like things are moving slow and we want to hurry up and start,I guess there is a lot of protocols to go thru.

Cynthgob profile image
Cynthgob in reply toBobkar

It took us awhile to get things going too. But the thing they reassured me is that he was already in treatment as the hormone shots and pills are working against the cancer right now. We finished chemo Tuesday and now he has the flu. I cannot imagine how bad he must feel. Lupron shot, chemo and the flu. We just got home from hospital now.

Tall_Allen profile image
Tall_Allen in reply to

Apalutamide was only approved for castration-resistant prostate cancer that is not metastatic, a relatively rare indication.

Bobkar profile image
Bobkar in reply toTall_Allen

Yes , that is also what we were told. Thank you. He is definitely going on the trial just waiting for more scans, paperwork etc it just seems so long to wait even though he is receiving the lupron, casidex.

Tall_Allen profile image
Tall_Allen

If this is the ARASENS trial, it is a really good one. BOTH groups get docetaxel, which has already been proven to extend survival in men who are detectably metastatic and hormone sensitive. If he is in the darolutamide placebo group, he will still be eligible for other therapies later. For a discussion of his options and other clinical trials, see:

pcnrv.blogspot.com/2017/06/...

Bobkar profile image
Bobkar in reply toTall_Allen

Yes this is the trial,, pray it works.

Cynthgob profile image
Cynthgob in reply toBobkar

How is your brother? Has his psa dropped to 0? I am worried as my husbands is still hanging around 7. Did he finish his chemo? Pray that it worked.

Bobkar profile image
Bobkar in reply toCynthgob

Cynthgob, I just replied to another message that you posted and then I saw this message. That is so strange we must be on the same pathway!!!! I was just telling my sister earlier that I was going to ask if your husband had his F/U scans after last chemo.praying they gave you some relief. My brother has one chemo left then 3 wks later repeat all scans which is good since we thought it would be 3 MONTHS later. PSA down 0.5 Alk Phos 40 still has shoulder pain and dr and trial said he could get it injected and not effect trial. Then he was told will only stay on trial and lupron for now....hope and pray these 2 men will be well. Please keep me updated.

Cynthgob profile image
Cynthgob in reply toBobkar

Yes he had his follow up scans and all looked stable. His psa is 7.0! I’m not really happy with that. They are doing scans sept 12 . He is doing pretty well. Able to work out . I think if he was on odm he would be at 0. So am anxious about September . We are planning trips right now and just trying to get as much out of each day that we can. Everything I read about psa makes me worry that he hasn’t had better results .

Bobkar profile image
Bobkar in reply toCynthgob

Completely understand. The only comfort that has helped is the oncologist and trial drs. Have said that on this trial it is significant when your PSA is so high to start with and does respond and quickly drop that that is also one of the grading tools that they use to show progress. Ex. Brothers was around 2800-200-0.5 somehow there is a formula that is used to determine effectiveness so your husbands may not be in NORMAL range yet but is progressing.

Not what you're looking for?

You may also like...

Drug 17777 or ODM-201

Husband is in clinical trial combining docetaxel and ODM-201. I was wondering if anyone here is on...
Cynthgob profile image

Another promising androgen blocker in clinical trials: Darolutamide (ODM-201)

Another second line androgen blocker, Darolutamide is in phase III clinical trials. It's showing...

New Drug BAY1841788 (ODM-201) has been successful for CRPC patients, Clinical trial Phase III completed.

This drug is for patients with Castration Resistance Prostate Cancer , apparently the clinical...
bboby profile image

Chemo or clinical trial?

Am scheduled for bone biopsy of met(s) from my hip tomorrow. Stopped Pluvicto after #3 due to...
rsgdmd profile image

Clinical trial using Enzalutamide and Cisplatin

My oncologist has suggested a clinical trial involving Enzalutamide and Cisplatin. Right now I am...
Newyork6264 profile image

Moderation team

Bethishere profile image
BethishereAdministrator
Number6 profile image
Number6Administrator
Darryl profile image
DarrylPartner

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.