Hi all. My husband’s MPC has become resistant to all standard treatment. Xtandi was discontinued in May, as PSA began to rise again and lymph node cluster was growing. 2nd line chemo was done May-August, but PSA rose between every treatment, lymph node cluster doubled in size, two new bone mets appeared. He has qualified for an immunotherapy clinical trial for which he will sign consent this week. Obviously, his cancer is aggressive. Here is my question- He has not yet tried Zytega. The doctor said it only has a 30-35% chance of helping since he became resistant to Xtandi. My husband feels like the experimental route is the only way to go at this point, and doesn’t want to lose his spot in the trial. I am a wreck about the trial, as dosing can be toxic, side effects unknown, effectiveness unknown, etc. My mind keeps coming back to Zytega. Any thoughts? P.S. our son is getting married July 2019. Our main goal is for him to make it to the wedding.