Clinical trial Xtandi and Keytruda - Advanced Prostate...

Advanced Prostate Cancer
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Clinical trial Xtandi and Keytruda

My husbands oncologist has suggested a clinical trial. Xtandi plus infusion of Keytruda every 3 weeks for 2 years. Has anyone heard of this? Scary side effects from Keytruda it seems, but makes sense to boost immune system to fight. PSA now up to 8.7, has been on Zytiga for 3 years with great result now failing. He has to stop Zytiga and Onco said don't panic is psa jumps to 12 before we start trial in January. Options are just Xtandi, or chemo, so scared.

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In order for the keytruda to work you must have the correct genetic markers. I suspect you will need to do some genetic testing before they will let him into the trial..When Zytiga fails, there is little chance Xtandi will work effectively or for very long. This trial must have a name and a trial number. Please post them if you can..Is the trial location nearby to where you live ?

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Fairwind is quite correct. There are a couple of reports that Xtandi worked longer than 6 months after failure on Zytiga. Most times you get just 2-3. The culprit seems to be the AR-V7 gene splice. Sometimes rarely the gene splice turns off from---- in plain speak from positive to negative. My understanding, is there must be a finding of the marker Pdl-1---for Keytruda to be selected. And it is not approved for Pca, but Trials can use it. If going forward in this realm, getting tested for the AR-V7 gene splice, and the Pdl-1 may be worthwhile in providing more info. If doing genetic testing--you might as well get the whole deal including gene mapping to determine any Mutated genes. Many here use Foundation One--for this--they have an 800 number at their web site--you get hooked up to a advocate, who can sometimes provide more info than a run of the mill oncologist. Also if seeking more info than us amateurs you can contact PCRI--and speak to and get a full time Advocate--where they have lots of info, contacts, trials etc.

Nalakrats

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The trial is MK 3475-365 study sponsor, Merck sharp & Dohme, at Rutgers Cancer Institute in New Brunswick NJ We live in NJ so convenient. He had Guardant testing, plus another test that apparently showed he would benefit from Zytiga or Xtandi. He did very well on the Zytiga, but obviously with psa of 8.7 and rising, no longer working. I am concerned with side effects of both Xtandi and Ketruda also going for these infusions every 3 weeks for 2 years!! Not sure what to do at this point. He has been fighting for 7 1/2 years with Gleason 8/9 and psa of 22 and feeling good, hate to see him now feel horrible unless it will keep this monster in check

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My guess the test he had was for the AR-V7 gene splice--that it was negative, or in a turned off position, so either Zytiga or Xtandi would work--as long as this Gene Splice stayed negative--when it goes positive these drugs fail--so I just wonder about the efficacy of using Xtandi at all--all the Keytruda uses I know of--have been by itself--but I am not following any combinations--and lightly on Keytruda--as there are not many men here that have reported on its Off Label Use for Pca. I assume your husband tested positive for the Pdl-1 marker, thus indicating Keytruda has a chance to work.

Nalakrats

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As I've posted here ad nauseam I am being treated for stage IV Melanoma of the lungs besides my Pca. I have had 15 treatments with Keytruda and it's working. I did NOT have any side effects from these treatments. Each treatment is $30K.

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 12/02/2018 1:00 AM EST

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Thank you John, and good luck to you. Since this is clinical trial the Keytruda will be free, thank God as we couldn't afford otherwise

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Has it helped PCa or only melanoma?

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Melanoma...

I asked both my Pca and Melanoma Oncologists whether or not the Keytruda would be beneficial with my fight against Pca? Both said NO.

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 12/02/2018 4:37 PM EST

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Where are they doing Xtandi and keytruda?

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Rutgers Cancer Institute New Brunswick nj

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