What's next after my failure of ARV-1... - Advanced Prostate...

Advanced Prostate Cancer

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What's next after my failure of ARV-110 trial

HopingForTheBest1 profile image

Am I missing out on having a proven effective treatment of Carboplatin + Taxane/Docetaxel chemo, since I am BRCA2+, by going on to another trial instead? Next trial is possibly AC225 + Xtandi + Keytruda combo therapy.

Trial effectiveness is clearly unknown, and could possibly make me too weak to handle chemo? I have been on more trials than on SOC treatments at this point. No chemo to date. While I may be helping others by participating in these trials, I am not really helping myself so far.

I am still here 3 years since initial diagnosis of pelvic bone metastatic PC and Gleason 10. But PSA is rising (from 4.3 to 9.8) and one lesion has grown 20% while on the ARV-110 trial for 8 weeks. Testosterone has been in the single digits with ongoing ADT.

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HopingForTheBest1
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4 Replies
Tall_Allen profile image
Tall_Allen

If you go for carboplatin+taxane, that qualifies you for clinical trials that require previous chemo.

NWLiving profile image
NWLiving

My husband did not have any significant side effects from dosetaxel. And it seemed to keep back the beast for a significant time....

HopingForTheBest1 profile image
HopingForTheBest1 in reply to NWLiving

With undetectable, or very low, PSA? And clean scans?

NWLiving profile image
NWLiving in reply to HopingForTheBest1

I think his lowest PSA was .44. He remained pain free with a low PSA for about 18 months following the treatment. He started with bone Mets so seems like a win. The scans were also stable.

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