Next Step Docetaxel after Abiraterone & Xtandi failed.

[Yadifan]

After being on abiraterone for 10 months, my husband's PSA numbers started climbing again. His doctor switched him to Xtandi in July of this year. Hubby's PSA climbed from 35.5 in August to 78.6 in October after being on Xtandi for 3 months. Had nuclear bone scans and CT scans done again a few weeks ago. CT scans show no soft tissue involvement. Bone scan showed persistent uptake in most areas. Our next step is Docetaxel starting soon. I asked the doctor if after chemo he would try ADT again. He told us it wouldn't work again. It seems that I've read on this site that it can be reintroduced with success after chemo. Has anyone here had any experience with that? Hubby's has some pain issues with his back and left arm (the left arm being a newer pain). I was wondering how long after starting chemo would he start to feel some pain relief? He's scheduled next week for a port and a bone marrow biopsy. Genetic testing and immunotherapy testing will be done.

Thank you in advance for all your help and advice and sharing your stories. I admire the strength and compassion of everyone here.

Blessings,

Marie

[Tall_Allen]

Why not try to rechallenge with Zytiga after chemo? It seems he has nothing to lose, and everything to gain.

[Yadifan in reply to Tall_Allen]

Thank you TA. "Rechallenge" was the term I was looking for. It seems like this wife has a little lupron fog going on. I will push for this. I appreciate your quick reply.

[Brackenridge in reply to Tall_Allen]

Hello Tall_Allen - could XTandi be the rechallenger after Docetaxel or does it have to be Zytiga? My Dad is in the midst of chemo but just wondering for the future and he had longer efficacy with XTandi than Zytiga previously. 5 sessions of Docetaxel has brought his PSA down from 274 to 114 so fingers crossed the decline continues. He hasn’t had new scans done yet but we’re hopeful 🤞🏻🙏🤞🏻🙏🤞🏻🙏🤞🏻🙏

[Tall_Allen in reply to Brackenridge]

Which did he have first?

[Brackenridge in reply to Tall_Allen]

XTandi. I pushed for my Dad to switch to dexamethosone (sp?) from Prednisone when it was apparent the Zytiga was quite ineffective but to no avail with his MO. SIGH. Thank you for your incredible knowledge and for this site - keeps me sane at times.

[Tall_Allen in reply to Brackenridge]

So it makes sense that the first one lasted longer. Cross resistance kept the Zytiga from working. After chemo, maybe he can try to get in on a clinical trial for Erleada, Nubeqa, or one of the experimental hormonal agents?

[Brackenridge in reply to Tall_Allen]

I hope so. His MS has been pretty strained by the chemo and he’s had to fight to keep his mobility through the treatments. The MS looms large in treatment options. We will talk to his doctor about clinical trials that might be a good fit after chemo. Anyone participating in Moffitt trials?

[j-o-h-n]

Hello Marie, I've posted this many times. And it may be apples to oranges, but I have received Keytruda (Immunotherapy drug) for my lung melanoma and it's working. I keep seeing advertisements on tv that Keytruda is a meds to fight "cancer". Let's hope it works for your dear husband.

To steal a little thunder from you: "We admire the strength and compassion of all the wonderful caregivers like you".

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 11/10/2020 6:35 PM EST

[Yadifan in reply to j-o-h-n]

Thank you j-o-h-n. I will ask about Keytruda also. I recall seeing those commercials also. I'm glad it's helping you in your battle. Stay tough and thank you for helping all of us smile every now and then.

[Kevinski65 in reply to Yadifan]

Can he take aspirin or maybe ,Celebrex with Zometa? Bringing down inflammation is important as well as strengthening bones.