Hi, can anyone help? Hoping to hear from anyone with experience in next treatment/step after docetaxel failed and Xtandi failed? Or places for further consults? Dear husband Barry first failed docetaxel (5 treatments), and then Xtandi failed after 6 weeks, PSA rising. Still on Lupron, continuing Xtandi for now. Diagnosed last August with PC with extensive bone mets, PSA was 49. It initially went down, then went up after second chemo treatment (he had 5 treatments).
I admit this is scary -- I didn't think the cancer would become resistant this fast. He's still feeling okay, exercising. Scans are scheduled next week, I think biopsy and genetic testing will come. I feel I really need the group's collective experience. Not sure if MO will recommend carboxitaxel (Jetvana) or something else.
Other options, or trials? Any ideas for places for further consults? Telephone conference with MO scheduled next week after scans. Thanks all!!!!
Written by
Barbara345
To view profiles and participate in discussions please or .
My guess is they will recommend a chemo regimen based on what they see in the biopsy.
If there is NEPC, they will probably add a platinum-based chemo. There are different combinations depending on the IHC. There are also nueroendocrine blood markers that can be looked at: Chromogranin A, Synaptophysin, Neuron Specific Enolase and
As far as I know, they wouldn't be looked at by Foundation One.
The blood markers can support the diagnosis, but are not by themselves specific enough to be determinant.
They could also be used as "tumor markers" to help determine progression in the future since PSA is often not useful for this purpose in prostate cancers with significant neuroendocrine differentiation.
The blood markers are found with a blood test, just like you would get for anything else in your blood. Those markers are separate from the mutations. I would talk to Foundation One about IHC. Another option for that is Guardant360.
RP, then Radiation washout after a few years, then Lupron and .5mg of prednisone twice daily for more than ten years. Small doses of prednisone reduce tumor size and slow metastatic disease. I supplement with lots of mild botanicals.
Everyone’s biochemistry is different. If you aren’t getting enough assistance, explanation, and guidance from your Oncologist or Urologist, you need to move on and find another. Preferably one who has treated many cases of PCa and is young enough to be current.
The experimental therapy with the most potential for treatment with intent to cure is CART-T for Prostate Cancer. Check for Clinical Trials frequently. Many times advanced tests that are not funded by your health care insurer are funded as part of a clinic trial.
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.