canceractive.com/article/th...
Wonder what Nalakrats and Patrick make of the science?
canceractive.com/article/th...
Wonder what Nalakrats and Patrick make of the science?
16 years ago there were already papers that reported that the androgen receptor [AR] in prostatectomy samples was invariably "wild type" (normal) & that abnormalities were linked to ADT.
At the same time, papers were appearing that noted an early falling off of protective beta estrogen receptor [ERbeta] & an upregulation of pro-proliferation ERalpha.
PCa occurs in men who have experienced a 1-2% annual drop in testosterone levels since their early 30's (considered normal) - & often an increase in estradiol [E2] due to a build up of visceral fat. The E2:T ratio has been associated with other health issues, so why not PCa?
Note. E2 can drive down T levels, & is undesirable in otherwise healthy men - so why is it used in PCa? A massive dose of E2 will cause T production to cease. E2 cannot stimulate PCa in the absence of T.
-Patrick
This sounds like some bad advice.
See "Interesting stuff from CancerActive" above (prior post)....
Good Luck, Good Health and Good Humor.
j-o-h-n Wednesday 02/26/2020 6:24 PM EST
Nalakrats! I was referred to you and found you! Lol. Any initial guidance?
Hello. Brand new here! Diagnosed with Stage 4, Gleason 9 PCa during TURP surgery on 10/30/19. Mets to pelvic bones and bladder neck invasion. PSA has always been 2-3. ADT (Lupron and Erleada)has me at PSA of <.03. Confused about what’s next. MO says ride out ADT, urologist wants to remove prostate and bladder, RO wants to radiate all cancer areas. Any thoughts??