R-Lipoic Acid - Are there any counter indications or reasons not to take it?

[cesanon]

R-Lipoic Acid - Are there any counter indications or reasons not to take it?R-Lipoic Acid apparently helps with neuropathy. I seem to remember someone here saying that there are countervailing side effects or reasons why you might not want to take it. Any thoughts?

[cesces]

"Maybe aoxs are good for prevention and possibly they are bad for progression of existing cancers."

I have always wondered if that was the case.

You are the first person I have seen to express that speculation.

[tango65]

Smurtaw is right. This is some information supporting what he has clearly expressed:

cancer.gov/news-events/canc...

[cesces in reply to tango65]

HmmmSo that means you should not be supplementing with vitamin C?

That's my go to vitamin.

[cesces]

I'm interested in it for neuropathy.

[cesanon]

I do 2 grams of Vitamin C per day just for general health principles. LOL

[Cooolone in reply to cesanon]

Liposomal?

[KocoPr]

ROS concentrations for cancer patients is a conundrum.

On one hand you want your mitochondria working efficiently by lowering ROS., but if we let enough free radicals clog our mitochondria our good and bad cancer cells die. During chemo, and radiation we are building up ROS to help cell death along especially on the faster growing cancer cells, but hair, gut/mouth, and skin cells also die. I can see not taking antioxidants during this time. My consternation is I always here prostate cancer is a slow growing cancer so in order to supposedly kill our PCa cells we are slowly aging all of our cells faster than a high or normal antioxidant healthy diet would do.

I did stop taking all of my mitochondria support vitamins, and am reluctant to take R lipoic acid. I even stopped my B12 self injections. I do take a multivitamin but once or twice a week depending on how im feeling.

For your peripheral neuropathy

I had peripheral neuropathy before cancer diagnosis and i was fairly healthy with normal glucose levels so it wasn’t diet related. I asked for a B 12 panel and it came back normal it include homocysteine but they did not include methylmalonic acid (MMA). I got the MMA test and it showed that i was not metabolizing my methylcobalamin.

Here is a good nih article from 2016 on B12, peripheral neuropathy, Himocystein, and Methylmalonic acid.

ncbi.nlm.nih.gov/pmc/articl...

[Cooolone]

Yes indeed, there's information supporting both sides of the argument. Interesting rabbit hole to deep dive into is the "Oxidative Stress" environment and it's effect upon cellular function.

This go round with radiation I just completed, I laid off the AOX and tried to oxidize as much as possible. Daily walks and also sucking down some oxygen (canned), prior to and post, each therapy session, lol. No proof of anything, just my own thoughts, to pump up the Ox a bit even of just a small bit. Lol

Good stuff

[FRTHBST]

I have read one theory behind possible efficacy of high dose IV vitamin C is that it becomes a powerful oxidant when delivered directly to the bloodstream at these more concentrated levels. Most non cancerous cells have enzymes to deal with this, some cancers do not and the resulting caspase cascade induces apoptosis. It doesn't work with every cancer, but can in some cases be beneficial. One good aspect is vitamin C's low toxicity, so to try one is only out some $'s.

[FRTHBST]

That's interesting about wear and tear and measurement with glucometer. Was it effective for the guy you knew? I did try it for about 8 months 2x a week. I understand some people have had it even more frequently than 3x. And it did set me back about $400 a week(ouch-that hurt more than the needle). It was not long after my diagnosis and I was exploring every avenue that didn't present a clear physical downside. In my case I don't think it had any great effect.

[Purple-Bike]

What Russ writes, and the article posted by tango65 indicates even though it is a mouse study, is disconcerting. Many of us are taking often strong antioxidants for antiinflammatory and low-level evidence of anti-cancer effects. Curcumin, EGCG, melatonin, lycopene, nattokinase, zinc... you name it. If there is low-level evidence that these could aid progression of existing cancer, wouldnt prudence dictate that one not take these?

[cesanon in reply to Purple-Bike]

While not exactly a good trials for our purposes.

It is certainly logical, isn't it.

[Purple-Bike]

Russ, would you mind commenting on my message of the possible prudence of quitting all aox? If there is a small risk of cancer progression for each, one or two or two of them just might actually cause this.......?

[Purple-Bike]

Antioxidants have anti-inflammatory and some other benefits, and may prevent new cancer. But carry a (small?) risk of worsening progression of existing cancer. Doesn´t seem like that great a trade-off... does temper enthusiasm for those substances!

Melatonin is the one substance that seems safe perpetually. As you say, proox at 10 mg. I will go down to that from the 20 mg I have been taking.

Phew, this is a big thing! I recall similar warnings about aox from TA earlier but only now does it sink in. That it actually may be a factor. A game-changer for many supps, if one follows thru on this. Cycling for less than half of the year, perhaps......

[cesces]

What exactly do you take?

[cesces]

I am not currently under ADT or bat.

Just trying to get some insight about what Ros you take and what your strategy is.

[Purple-Bike]

Meaning aox 25 % of the time?

[cesces]

What are Ros agents that can be commonly used?

How much melatonin is low dose? How much is high dose?

What is there other than melatonin?

[cesces]

Are there any other pro oxidants that might be of interest to the other folks here?