Does this counter view have any merit?

[CrocodileShoes]

canceractive.com/article/th...

Wonder what Nalakrats and Patrick make of the science?

[pjoshea13]

16 years ago there were already papers that reported that the androgen receptor [AR] in prostatectomy samples was invariably "wild type" (normal) & that abnormalities were linked to ADT.

At the same time, papers were appearing that noted an early falling off of protective beta estrogen receptor [ERbeta] & an upregulation of pro-proliferation ERalpha.

PCa occurs in men who have experienced a 1-2% annual drop in testosterone levels since their early 30's (considered normal) - & often an increase in estradiol [E2] due to a build up of visceral fat. The E2:T ratio has been associated with other health issues, so why not PCa?

Note. E2 can drive down T levels, & is undesirable in otherwise healthy men - so why is it used in PCa? A massive dose of E2 will cause T production to cease. E2 cannot stimulate PCa in the absence of T.

-Patrick

[Magnus1964]

This sounds like some bad advice.

[j-o-h-n]

See "Interesting stuff from CancerActive" above (prior post)....

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 02/26/2020 6:24 PM EST

[Canton44]

Nalakrats! I was referred to you and found you! Lol. Any initial guidance?

Hello. Brand new here! Diagnosed with Stage 4, Gleason 9 PCa during TURP surgery on 10/30/19. Mets to pelvic bones and bladder neck invasion. PSA has always been 2-3. ADT (Lupron and Erleada)has me at PSA of <.03. Confused about what’s next. MO says ride out ADT, urologist wants to remove prostate and bladder, RO wants to radiate all cancer areas. Any thoughts??