Does the new Circulating Tumor DNA blood test have any use for APCa patients?

[JPnSD]

Signatera is a personalized, tumor-informed assay optimized to detect circulating tumor DNA (ctDNA) for molecular residual disease (MRD) assessment and recurrence monitoring for patients previously diagnosed with cancer. Does it have a place in our APCa arsenal?

[Tall_Allen]

What decision are you trying to make based on it?

[JPnSD in reply to Tall_Allen]

At present on ADT (Orgovyx) and PSA undetectable....would this test indicate whether additional systemic drug intervention is needed for cancer cells present.....or if an ADT vacation might be prudent?

[Tall_Allen in reply to JPnSD]

Not that I know of. Someone has to try it for that purpose and see if it successfully predicts more or less therapy.

[JPnSD in reply to Tall_Allen]

Does it sound like it might make sense from a biochemical perspective?

[Tall_Allen in reply to JPnSD]

Like every test, it requires prospective tests.

[timotur]

I would think if a non-metastatic patient (M0) with a reliable test indicating a high CTC count would benefit from early chemo.

[ocman]

What is the cost of the test?

[MateoBeach]

Note that it is not the same as circulating tumor cell count CTCs. It is looking for non cellular (molecular) tumor DNA. Perhaps it could be a useful additional monitor for APC that does not produce PSA such as neuroendocrine PC. Just speculating.

[JPnSD in reply to MateoBeach]

Makes sense. But wouldn't it be beneficial for any form of PCa?

[MateoBeach]

Well if they can do genetic analysis on the DNA that could be valuable to those who don’t have sites that can be biopsied for genetics. But am doubtful they can do that. I was thinking more of a quantitative measure reflecting cancer burden growth and response to treatments when PSA is not produced. Otherwise PSA is much more convenient. Just speculating. 🤔

[Farmhand]

Looking for a liquid biopsy test to identify and quantify CTC's(Advanced metastatic prostate cancer). Has anyone had any luck finding a company which can accurately identify cancer stem cells including stemlike cells with EMT transition mesenchymal cells and Nuro endocrine cells? I am having a hard time finding a company which will offer testing commercially for individuals have only been able to find these type of asses available for clinical research

[Farmhand in reply to Farmhand]

"assays"