I have posted before re my progression. 12 years down the line now .Original PSA37 Gl 8. Ext Beam Radiotherapy and ADT for 2 yrs. ADT on and off until 2 years ago. then PSA climbed continuously to 14. Bicalutamide added to Zoladex, PSA dropped to 7 for a few months then started rising again so Bicalutamide stopped, PSA continuing to rise. expecting to go on to Aberaterone but CT scan showed no identifiable metastasis so NICE rules in UK say no Aabiraterone or Enxalutamide allowed. it seems I have to get more ill before I can better treatment. My oncologist is putting me on Dexamethasone and continuing monitoring. what will Dexamethasone do for me, hence the original question. I have had a very good quality of life up to now , side effects of zoladex practically non existent now.