PCa & Alzheimer's.

[pjoshea13]

New U.S. study below [1].

"Studies have demonstrated an inverse relationship between Alzheimer dementia (AD) and cancer."

"In addition, Pin1 expression has been implicated in the cell cycle regulation of both disease processes."

***

From Wikipedia [2]:

"Studies have shown that the deregulation of Pin1 may play a pivotal role in various diseases. Notably, the up-regulation of Pin1 is implicated in certain cancers, and the down-regulation of Pin1 is implicated in Alzheimer's disease."

Pin1 is Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1.

***

"A cross-sectional analysis was performed using discharge data from the National Inpatient Sample from 1999 to 2008. Cancer was defined as the primary discharge diagnosis and AD was defined as the secondary discharge diagnosis. Cancer types were grouped according to their Pin1 expression to examine its relationship with AD."

"Of ∼3 million cancer discharge diagnoses, 1.0% had a secondary diagnosis of AD. Discharge data of all 10 cancer types revealed a lower likelihood of secondary AD diagnosis. Prostate [crude odds ratios (OR): 0.26 .., multivariate OR: 0.39 ...] ..."

Impressive. I wonder how good the "secondary discharge" data is?

"When cancer types were grouped per Pin1 expression, cancer types with Pin1 underexpression were more likely to be associated with secondary diagnosis of AD than cancer types with Pin1 overexpression."

***

This is in contrast to a paper last year [3]:

"Association Between Androgen Deprivation Therapy Use and Diagnosis of Dementia in Men With Prostate Cancer."

"Among elderly patients with prostate cancer, ADT exposure was associated with subsequent diagnosis of Alzheimer disease or dementia over a follow-up period of at least 10 years."

***

I 'hedge my bets' by doing a puzzle from "Absolutely Nasty Kakuro (4)" with my morning coffee. When I come to the end of the book, my wife buys me another. That's Ok, since I never remember the puzzles! LOL

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/319...

Alzheimer Dis Assoc Disord. 2020 Jan 27. doi: 10.1097/WAD.0000000000000369. [Epub ahead of print]

Alzheimer Disease and Cancer: A National Inpatient Sample Analysis.

Sherzai AZ1, Parasram M2, Haider JM3, Sherzai D1.

Author information

1

Department of Neurology, Loma Linda University Health, Loma Linda.

2

Department of Neurology, Weill Cornell Medical College, New York, NY.

3

Department of Neurology and Neurosurgery, University of California, Los Angeles, CA.

Abstract

INTRODUCTION:

Studies have demonstrated an inverse relationship between Alzheimer dementia (AD) and cancer. This inverse relationship was further explored. In addition, Pin1 expression has been implicated in the cell cycle regulation of both disease processes. The relationship of Pin1 expression in 10 cancer types and secondary diagnosis of AD was examined.

MATERIALS AND METHODS:

A cross-sectional analysis was performed using discharge data from the National Inpatient Sample from 1999 to 2008. Cancer was defined as the primary discharge diagnosis and AD was defined as the secondary discharge diagnosis. Cancer types were grouped according to their Pin1 expression to examine its relationship with AD. Analysis was performed by logistic regression.

RESULTS:

Of ∼ 3 million cancer discharge diagnoses, 1.0% had a secondary diagnosis of AD. Discharge data of all 10 cancer types revealed a lower likelihood of secondary AD diagnosis. Prostate [crude odds ratios (OR): 0.26 (0.24 to 0.29), multivariate OR: 0.39 (0.35 to 0.43)], ovarian [crude OR: 0.38 (0.32 to 0.44), multivariate OR: 0.35 (0.30 to 0.41)], and lung cancer [crude OR: 0.39 (0.36 to 0.41), multivariate OR: 0.41 (0.39 to 0.44)] demonstrated the lowest odds of secondary AD diagnosis. When cancer types were grouped per Pin1 expression, cancer types with Pin1 underexpression were more likely to be associated with secondary diagnosis of AD than cancer types with Pin1 overexpression [crude OR: 1.4 (1.3 to 1.4), multivariate OR: 1.08 (1.02 to 1.14)].

DISCUSSION:

This secondary data analysis further demonstrated an inverse relationship between AD and 10 cancer types, with prostate, ovarian, and lung cancers displaying the greatest inverse relationship. Pin1 underexpressing cancer types had a significantly higher likelihood of secondary diagnosis of AD than Pin1 overexpressing cancer types.

PMID: 31990712 DOI: 10.1097/WAD.0000000000000369

[2] en.wikipedia.org/wiki/PIN1

[3] ncbi.nlm.nih.gov/pmc/articl...

[kmack57]

Great, we have that to look forward to as well!

[snoraste]

Absolutely - physical and mental activities

[Mjex]

Finally, a benefit from PCA, besides, of course, being a member of this group.

[PhilipSZacarias]

The type of ADT may have a bearing. I came across a paper that indicated that testosterone antagonists like bicalutamide increase the risk of AD. LHRH agonists and antagonists have differential effects on FSH and other hormones. Antagonists are reported to be better for people with pre-existing CVD. I am always impressed at the references that you provide to support your post - I have not organized my files in a way to easily find mine (it would take a long time). Cheers, Phil