Free PSA & Alzheimer's

[pjoshea13]

New study below [1]. Posted because of the odd finding.

I can't remember when I last saw a reference to free PSA [fPSA]. It was a big deal 15 years ago, although many men seemed to be getting biopsies purely on the basis of PSA.

"The risk of cancer increases if the free to total ratio is less than 25%." [2]

So it's good for free PSA to be higher? Seemingly not:

"fPSA serum levels were {four times} higher in {Alzheimer's disease} males ... compared to control males ..." [1]

So there might be an inverse association between Alzheimer's & PCa?

From December (Korea) [3]:

"... Lung and prostate cancer risks were ... significantly lower for the AD group (HR, 0.52 and HR, 0.72, respectively).

Conversely, also from 2018 (Taiwan) [4]:

"... the OR of prior Alzheimer's disease for prostate cancer patients was 1.52 ..."

Why "prior" Alzheimer's? Probably because ADT has been associated with future Alzheimer's in some studies [5].

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/309...

[2] en.wikipedia.org/wiki/Prost...

[3] ncbi.nlm.nih.gov/pubmed/309...

[4] ncbi.nlm.nih.gov/pubmed/294...

[5] ncbi.nlm.nih.gov/pubmed/266...

[cujoe]

Thanks, Patrick.

Since my urologist didn't use my low fPSA along with the stellar results of my first needle biopsy (12 cores, 6 with some cancer, 2 +50%, gleason 6, 66% total tissue involved) to recommend that I should consider immediate treatment, it is at least some consolation to find that I am at less risk for Alzheimer's . . . but . . . but . . . wait a minute . . . what forum am I posting to?? Be Well - ? ? ?

[j-o-h-n]

I was gonna post something here but I forgot what I was going to post.

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 04/14/2019 6:36 PM DST

[Garp41]

Higher estrogen leads to less Alzheimers and lower free PSA?

Doug

[pjoshea13]

Doug,

From a 2006 paper [1]:

"higher estrogen levels increase risk for cognitive decline and AD" {Alzheimer's disease}.

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/168...