Slowly But Surely Rising PSA

[Here4Dad]

Hi All!

Things have actually been going well. All things considered! My Dad continues to live life to the fullest with his metastatic prostate cancer. He has continued to work throughout treatments and has stents in his ureters to allow his urinary tract to function properly.

However, his last 3 appointments his PSA is creeping up. First, it was 0.3, then 0.4 and now 0.7 at the most recent appointment. His oncologist does not seem to be concerned but I am. At what point should we seek additional treatment?

He currently is on zytiga and his ct scan and bone scan show no new lesions. Any advice is welcome.

Thank you in advance ❤️❤️

[Here4Dad]

Thank you. I forgot to mention he is also on Lupron. What else should we consider?

[Tall_Allen]

Don't give up on Zytiga so soon. It is still working well if his scans show no new mets. Many oncologists will wait for PSA to rise over 2 and the appearance of new mets before giving up on Zytiga. Meanwhile, switching from prednisone to dexamethasone may extend the use of Zytiga.

onlinelibrary.wiley.com/doi...

[Here4Dad in reply to Tall_Allen]

Thank you so much 🙏🏻

[nycrunner]

Hi

I guess the concern I would have is when the PC becomes resistant to the Zytiga.

I have purchased a PEMF device from E Pulse Magnetics in LA.

For an explanation check out YouTube and especially the TED address by Bill Doyle.

I took Zytiga for about 2 weeks and stopped as my blood counts dropped and felt fatigued.

At the moment I feel good and closely monitor PSA.

I read in "How Not to Die" by M Greger 3 tablespoon of ground flax seed per day can stabilize and reduce PSA.

Good Luck

Dave

[Here4Dad in reply to nycrunner]

Thank you for your advice!

[hansjd]

Hi Here4Dad. My husband’s story sounds similar to your dad’s. When diagnosed almost two years ago, he was started on ADT and did 6 rounds of docitaxel. After about 10 months his PSA began to creep up from a nadir of 0.4 to 0.7 over about 4 months. His oncologist suggested adding bicalutamide which he did 10 months ago. He hadn’t had it earlier in his treatment because he is on Firmagon (an antagonist) not Lupron (an agonist) so needing to take it to counteract the flare caused by an agonist wasn’t an issue. After starting the bicalutamide his PSA stabilised and then dropped to a new nadir of 0.3. It’s risen only slightly just now, so it was effective for 10 months. Maybe longer as the current rise is only slight and his MO thinks it’s still working. Perhaps your dad could try adding bicalutamide and see if it’s effective for him. Just a thought. All the best.

[Here4Dad in reply to hansjd]

Thank you 🙏🏻

[j-o-h-n]

Concern is good....anxiety is bad.... Pat yourself on the back for being a wonderful daughter (btw can I adopt you?)

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 12/14/2019 10:48 AM EST

[Here4Dad in reply to j-o-h-n]

Thank you 🤗 my mom and brother passed away early in mine and my Dad’s life so we are very close. He’s all I have for a parent so I’m fiercely overprotective and feel responsible for his treatment and care. If that makes sense.