My Dad is Here with Me Now..Seeking Advice for Pain and Zytiga? Please help, need some insight...

[missh2]

Hello all, my Dad is here in Florida with me right now. The Dr. he saw at Cleveland Clinic advised Docetaxel and then Xofigo after that. He advised to discontinue Xtandi right away. His psa 9/19/19 was 16 and Psa drawn last week was 18. He has multiple bone mets. He is in some significant pain now that he is here, and he was having trouble with insurance getting set up to begin Docetaxel. We are still waiting to hear back from University hospitals to set up the first treatment which he will fly home for. He has to see an oncologist at University Hospitals first to then start the Docetaxel and that is the hold-up- getting him in with someone there.

We have two questions:

1. Should he try Zyitiga again just so he is hitting it with something while we get this appointment worked out? He was last one Zytiga in 2018. He went to Xtandi after that.

2. For pain, he has hydrocodone. He is going to take one now, but has not taken that since about 2017 at initial diagnosis. He takes aleve or tylenol and does not like to take pain killers. He took Tramadol that he was prescribed and that did not help. He also thinks some of the pain could be due to a kidney stone he knows he has that now seems to be moving. What works best for you for pain?

So- should he take Zytiga since he has it? Anyone have any thoughts that may help us? He feels pretty bad at the moment. Many thanks for any help you can offer.

We will be calling University hospitals on Monday morning; I should say I will be calling and making sure they do not put him off again. Many thanks-

Lora

[Tall_Allen]

(1) If Zytiga stopped working, there is no point in continuing. The cancer has learned to manufacture its own androgens. He should continue on Lupron, however. I think it might be synergistic to start on Provenge before docetaxel.

(2) Both docetaxel and Xofigo should help a lot with the pain. If he is still taking Zometa, he might discuss taking Celebrex with it. Not only does it relieve pain, but the combination of Celebrex and Zometa increased survival by 22% in metastatic men.

[j-o-h-n]

Could you describe/explain what your Dad means by pain due to a moving kidney stone? I've had a few of them and have some experience with pain from kidney stones...

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 11/17/2019 7:28 PM EST

[Captsquid2u]

I would be careful with aleve it can elevate liver enzymes, I take 10 mg 300 Tylenol, Vicodin. Works for me, and you get alittle endorphin bonus.

[Captsquid2u]

And Zytiga also can raise liver enzymes, watch your blood work!