CAR-T Cell Therapy

[PhilipSZacarias]

While only one type of immunotherapy, Sipuleucel-T, has yielded only modest improvements in survival most other types such as viruses, PD-1 and PD-L1 inhibitors, etc. have not been very effective, because of PCa's comparatively low mutational loads, I still have hope that immunotherapy will one day be the most effective means to achieve durable management of the diease (dare I say cure?)

The following two papers may be of interest to those who want an update on CAR-T cell therapy, which looks promising.

CART cell therapy for prostate cancer: status and promise

ncbi.nlm.nih.gov/pmc/articl...

CAR-T cell therapy: a potential new strategy against prostate cancer

ncbi.nlm.nih.gov/pmc/articl...

Cheers,

Phil

[tango65]

There are clinical trials with these cells :

clinicaltrials.gov/ct2/resu...

[PhilipSZacarias in reply to tango65]

Unfortunately, the trials do not include any in Canada.

[tallguy2]

Thank you for posting this. I completed the three rounds of Provenge last month. As advertised, Provenge did not lower PSA nor did it reduce the cancer burden (small) in my body. In fact, my PET/CT with Axumin revealed 3 new mets last week (!)

I agreed to Provenge because it was shown to "prolong life" in clinical trials. A 13 month advantage for men with a PSA <20. For guys like me with a PSA <2? Who knows.

[I add that my research MO thinks Provenge is so- last decade. It is all about abiraterone plus PARP inhibitors and new drugs that target certain genetic mutations.]

[PhilipSZacarias in reply to tallguy2]

I agree with your oncologist re PARP inhibitors. I was recently tested for a panel of DNA repair defect genes because my oncologist wants to see if I can qualify for a trial testing PARP inhibitors he is recruiting for. Cheers, Phil

[tallguy2 in reply to PhilipSZacarias]

I am waiting on the results of a tumor biopsy completed last week. I too hope to qualify for a trial.

[PhilipSZacarias in reply to tallguy2]

I hope you qualify. Cheers, Phil