CAR-T Cell Therapy Trials

Most of these trials are in the recruiting stage. This is a followup of Nal's thoughtful CAR-T Cell Therapy explanation: healthunlocked.com/advanced...

Thanks Nal.

Courtesy of Tango:

bloomberg.com/press-release...

ascopubs.org/doi/abs/10.120...

Trials:

Study 1:

Title: A Study of JNJ-75229414 for Metastatic Castration-resistant Prostate Cancer Participants

Status: Recruiting

Study Results: No Results Available

Conditions: Prostatic Neoplasms

Interventions: Drug: JNJ-75229414|Drug: Bridging Therapy

Locations: City of Hope Cancer Center, Duarte, California, United States|Cedars-Sinai Medical Center, West Hollywood, California, United States|Emory University - Winship Cancer Institute, Atlanta, Georgia, United States|Norton Cancer Institute, Louisville, Kentucky, United States|Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States|University Of Minnesota, Minneapolis, Minnesota, United States|Icahn School of Medicine at Mount Sinai, New York, New York, United States|Columbia University Medical Center, New York, New York, United States|Levine Cancer Institute, Charlotte, North Carolina, United States|University of Pennsylvania, Philadelphia, Pennsylvania, United States|University of Utah Huntsman Cancer Institute, Salt Lake City, Utah, United States

URL: ClinicalTrials.gov/show/NCT...

Study 2:

Title: P-PSMA-101 CAR-T Cells in the Treatment of Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Status: Recruiting

Study Results: No Results Available

Conditions: Prostatic Neoplasms, Castration-Resistant|Neoplasms by Histologic Type|Neoplasms, Prostate|Prostate Cancer|Metastatic Castration-resistant Prostate Cancer|Neoplasms|Prostatic Neoplasms|Genital Neoplasms, Male|Urogenital Neoplasms|Neoplasms by Site|Prostatic Disease

Interventions: Biological: P-PSMA-101 CAR-T cells|Drug: Rimiducid

Locations: City of Hope Comprehensive Cancer Center, Duarte, California, United States|University of California San Diego, San Diego, California, United States|University of California San Francisco, San Francisco, California, United States|Sarah Cannon Research Institute at HealthONE, Denver, Colorado, United States|University of Maryland, Baltimore, Baltimore, Maryland, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, United States|Massachusetts General Hospital, Boston, Massachusetts, United States|Memorial Sloan Kettering Cancer Center, New York, New York, United States

URL: ClinicalTrials.gov/show/NCT...

Study 3:

Title: PSCA-CAR T Cells in Treating Patients With PSCA+ Metastatic Castration Resistant Prostate Cancer

Status: Recruiting

Study Results: No Results Available

Conditions: Castration-Resistant Prostate Carcinoma|Metastatic Prostate Carcinoma|Stage IV Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8|Stage IVB Prostate Cancer AJCC v8

Interventions: Biological: Autologous Anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes|Drug: Cyclophosphamide|Drug: Fludarabine|Drug: Fludarabine Phosphate

Locations: City of Hope Medical Center, Duarte, California, United States

URL: ClinicalTrials.gov/show/NCT...

Study 4:

Title: PD1 Integrated Anti-PSMA CART in Treating Patients With Castrate-Resistant Prostate Cancer

Status: Not yet recruiting

Study Results: No Results Available

Conditions: Castrate-Resistant Prostate Cancer

Interventions: Drug: PD1-PSMA-CART cells

Locations: The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China

URL: ClinicalTrials.gov/show/NCT...

Study 5:

Title: A Study of CART-PSMA-TGFβRDN in Patients With Metastatic Castration Resistant Prostate Cancer

Status: Active, not recruiting

Study Results: No Results Available

Conditions: Metastatic Castration-resistant Prostate Cancer

Interventions: Biological: CART-PSMA-TGFβRDN|Drug: Cyclophosphamide|Drug: Fludarabine|Drug: Anakinra

Locations: Moffitt Cancer Center, Tampa, Florida, United States|The University of Kansas Hospital, Kansas City, Kansas, United States|Washington University School of Medicine, Saint Louis, Missouri, United States|Columbia University Medical Center, New York, New York, United States|University of Pennsylvania, Philadelphia, Pennsylvania, United States|Thomas Jefferson University, Philadelphia, Pennsylvania, United States|University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States|Sarah Cannon Research Insitute, Nashville, Tennessee, United States|University of Washington Medical Center, Seattle, Washington, United States

URL: ClinicalTrials.gov/show/NCT...

Study 6:

Title: Safety and Activity Study of PSCA-Targeted CAR-T Cells (BPX-601) in Subjects With Selected Advanced Solid Tumors

Status: Recruiting

Study Results: No Results Available

Conditions: Metastatic Castration-resistant Prostate Cancer|Metastatic Prostate Cancer|Metastatic Pancreatic Ductal Adenocarcinoma|Metastatic Pancreatic Cancer|Metastatic Pancreatic Adenocarcinoma

Interventions: Biological: BPX-601|Drug: Rimiducid

Locations: Moffitt Cancer Center, Tampa, Florida, United States|Emory Winship Cancer Institute, Atlanta, Georgia, United States|John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey, United States|Columbia University Medical Center, New York, New York, United States|Tennessee Oncology, PLLC, Nashville, Tennessee, United States|Baylor Sammons Cancer Center, Dallas, Texas, United States|The University of Texas MD Anderson Cancer Center, Houston, Texas, United States

URL: ClinicalTrials.gov/show/NCT...

Study 7:

Title: Dose-escalating Trial With UniCAR02-T Cells and PSMA Target Module (TMpPSMA) in Patients With Progressive Disease After Standard Systemic Therapy in Cancers With Positive PSMA Marker

Status: Recruiting

Study Results: No Results Available

Conditions: Prostate Cancer

Interventions: Drug: Cyclophosphamide (Non-IMP)|Drug: Fludarabine (Non-IMP)|Drug: UniCAR02-T-pPSMA|Drug: UniCAR02-T (IMP)

Locations: Universitätsklinikum Ulm, Ulm, Baden-Württemberg, Germany|Universitätsklinikum Würzburg, Würzburg, Bayern, Germany|Universitätsklinikum Dresden, Dresden, Sachsen, Germany|Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

URL: ClinicalTrials.gov/show/NCT...

Study 8:

Title: A Clinical Research of CAR T Cells Targeting EpCAM Positive Cancer

Status: Unknown status

Study Results: No Results Available

Conditions: Colon Cancer|Esophageal Carcinoma|Pancreatic Cancer|Prostate Cancer|Gastric Cancer|Hepatic Carcinoma

Interventions: Biological: CAR-T cell immunotherapy

Locations: IEC of Chengdu Medical College, Chendu, China

URL: ClinicalTrials.gov/show/NCT...

Study 9:

Title: Haplo / Allogeneic NKG2DL-targeting Chimeric Antigen Receptor-grafted γδ T Cells for Relapsed or Refractory Solid Tumour

Status: Unknown status

Study Results: No Results Available

Conditions: Colorectal Cancer|Triple Negative Breast Cancer|Sarcoma|Nasopharyngeal Carcinoma|Prostate Cancer|Gastric Cancer

Interventions: Biological: Adoptive Cell Transfer of NKG2DL-targetting Chimeric Antigen Receptor-grafted Gamma Delta T cell

Locations: Landmark Medical Centre, Johor Bahru, Johor, Malaysia

URL: ClinicalTrials.gov/show/NCT...

Study 10:

Title: CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors

Status: Recruiting

Study Results: No Results Available

Conditions: HER2-positive|Adenocarcinoma|Bile Duct Cancer|Biliary Tract Cancer|Bladder Cancer|Breast Cancer|Breast Neoplasm|Carcinoma, Ductal|Carcinoma, Hepatocellular|Cancer|Lung Cancer, Non-Small-Cell|Carcinoma, Ovarian Epithelial|Carcinoma, Small Cell|Carcinoma, Squamous|Carcinoma, Transitional Cell|Colorectal Cancer|Esophagogastric Junction Neoplasms|Inflammatory Breast Cancer|Stomach Neoplasms|Malignant Neoplasms|Ovarian Neoplasms|Pancreatic Cancer|HER2-positive Solid Tumors|HER2-positive Breast Cancer|HER2-positive Gastric Cancer|HER-2 Protein Overexpression|HER-2 Gene Amplification|Prostate Cancer|Head and Neck Cancer|Endometrial Cancer|Lung Cancer, Small Cell

Interventions: Biological: CT-0508

Locations: City of Hope National Medical Center, Duarte, California, United States|UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, United States|Abramson Cancer Center, Philadelphia, Pennsylvania, United States|M D Anderson Cancer Center, Houston, Texas, United States

URL: ClinicalTrials.gov/show/NCT...

Study 11:

Title: PSMA-specific CAR-T Cell Therapy

Status: Recruiting

Study Results: No Results Available

Conditions: PSMA Positive Tumors or Tumor Tissues

Interventions: Biological: 4SCAR-PSMA T cells

Locations: Shenzhen Children's Hospital, Shenzhen, Guangdong, China|Shenzhen Geno-immune Medical Institute, Shenzhen, Guangdong, China|Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, China|The Seventh Affilliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China

URL: ClinicalTrials.gov/show/NCT...

[Hidden]

That's a lot to digest. Are any of these for other than castrate resistant? Obviously my cancer is responding to ADT, hence my undetectable PSA, but when I go off of it is going to be a whole different situation, maybe, hopefully not.

[Hidden in reply to Hidden]

I didn't see any for HSPC. I think that the push right now would be to work on something beneficial to use after the slam dunk of ADT fails (2+ years).

But if CAR T works on CRPC then it should work on HSPC.

[Hidden]

Sure. It was actually embarrassingly easy to collect the trials. I just went to clinicaltrials.gov, entered cancer and CAR T in the search. When the results came up I downloaded them in a text format. Opened in notepad and copied/pasted.

Another really cool thing is to use an RSS reader and subscribe to a clinicaltrials.gov feed. You enter your search criteria and get any trials that are updated or posted within a timeframe you specify (I get all prostate cancer trials with results that have been updated within 14 days, I also made feeds for CAR T and BAT). I just noticed that a BAT trial was updated today...

I could paste screenshots of the steps if you want.

[Hidden in reply to Hidden]

This is the BAT trial that was updated: clinicaltrials.gov/ct2/show...