Trichomonas vaginalis

[pjoshea13]

New study below [1].

"Trichomonas vaginalis is an anaerobic, flagellated protozoan parasite and the causative agent of trichomoniasis. It is the most common pathogenic protozoan infection of humans in industrialized countries. Infection rates between men and women are similar with women being symptomatic, while infections in men are usually asymptomatic. Transmission usually occurs via direct, skin-to-skin contact with an infected individual, most often through vaginal intercourse. The WHO has estimated that 160 million cases of infection are acquired annually worldwide. The estimates for North America alone are between 5 and 8 million new infections each year, with an estimated rate of asymptomatic cases as high as 50%." [2]

There are 26 PCa hits on PubMed, where papers often open by describing the role of Trichomonas vaginalis (TV or T. vag) as being "controversial.

Unlike other STDs, a man might have no symptoms - providing oportunity for prostate infection.

[3] Studies where Siobhan Sutcliffe was the lead, author or co-author. It's a mixed bag.

[3a] (2006 - U.S. - Health Professionals Follow-up Study)

"Although several previous case-control studies have investigated associations between sexually transmitted infections (STI) and prostate cancer, most have focused on gonorrhea and syphilis, two well-recognized, symptomatic STIs. Another STI of interest for prostate carcinogenesis is trichomonosis, a less well recognized and frequently asymptomatic STI with known prostate involvement."

"Thirteen percent of cases and 9% of controls were seropositive for trichomonosis (adjusted odds ratio, 1.43 ...)"

"Interestingly, this association was strongest among men who rarely used aspirin, and weakest among men who used aspirin regularly over the course of their lives and thus presumably at the time of infection."

[3b] (2009 - U.S. - Prostate Cancer Prevention Trial)

"No association was observed between T. vaginalis serostatus and prostate cancer. 21.5% of cases and 24.8% of controls had low seropositivity, and 15.2% and 15.0% had high seropositivity."

[3c] (2009 - U.S. - Physicians’ Health Study)

"Although not statistically significant, the magnitude of the association between T vaginalis–seropositive status and overall prostate cancer risk (OR = 1.23 ...) was similar to that reported previously {in [3a]}."

"Furthermore, a seropositive status was associated with statistically significantly increased risks of extraprostatic prostate cancer (OR = 2.17 ...) and of cancer that would ultimately progress to bony metastases or prostate cancer–specific death (OR = 2.69 ...)."

[3d] (2013 - U.S. - Health Professionals Follow-up Study again)

"... we investigated effect modification by Toll-like receptor 4 (TLR4) variation on" the "positive association between Trichomonas vaginalis serostatus and risk of prostate cancer"

"Although not statistically significant, TLR4 variation appeared to influence the association between T. vaginalis serostatus and prostate cancer risk consistent with the hypothesis that inflammation plays a role in this association."

[3e] (2016 - U.S.)

"A total of 146 men with advanced (metastatic or fatal) prostate cancer and 181 age-matched controls were selected from two prior population-based, case-control studies."

"The seroprevalence of Tv in controls was 23%. Tv serostatus was not associated with an increased risk of metastatic or fatal prostate cancer (ORs < 1)"

...

In the new study ("Trichomonas vaginalis: a possible foe to prostate cancer."):

"Prostate cancer (PCA) is the most common malignancy in men in USA, and the role of Trichomonas vaginalis (T. vag) in the development of PCA is still controversial."

"Culture supernatant of T. vag inhibits growth of PC-3 prostate cancer cells ..."

"Culture supernatant of T. vag induced apoptosis of PC-3 cells"

"The growth inhibition effect of culture supernatant of T. vag is also demonstrated in another prostate cancer cell line DU145, suggesting that its effect is not specific to one prostate cancer cell line."

"Culture supernatant of T. vag inhibits growth of prostate cancer by inhibition of proliferation and promotion of apoptosis."

{"supernatant" is a liquid - perhaps obtained via centrifugation}

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/276...

[2] en.wikipedia.org/wiki/Trich...

[3a] cebp.aacrjournals.org/conte...

[3b] ncbi.nlm.nih.gov/pmc/articl...

[3c] ncbi.nlm.nih.gov/pmc/articl...

[3d] ncbi.nlm.nih.gov/pmc/articl...

[3e] ncbi.nlm.nih.gov/pubmed/268...

[BigRich]

I think a couple weeks of Cipro would not out the infection. There are so many ways this disease can be influenced to grow. I believe, if there is a correlation then its due to inflammation.

Rich

[pjoshea13]

Nalakrats,

I have an old list, but, in effect, my series of posts on "Foods/Supplements-Vitamins" will be the new list, when completed. But I must clean up my list at some point.

& I am very interested in how your list differs. Stuff I don't know about, or disregarded for some reason.

& then there is the assessment of each.

Equally of interest to some, perhaps, are the supplements that we both view as having no value. We can't both be wrong - LOL.

-Patrick

[Hidden]

I've been told to lay off red meat and dairy as these presumably fuel the growth of PCa. Taking eligard, along with omeprazole, which both interfere with calcium absorption. Eligard in particular requires monitoring of bone health and osteoporosis. So how do I ingest enough calcium, other than slamming Tums? Thanks.

Ed

[pjoshea13 in reply to Hidden]

Ed,

I don't know how Omeprazole (Prilosec), a proton pump inhibitor, affects bone - or rather, how that can be circumvented - but for Eligard (Lupron), I suggest the following.

Have an estradiol [E2] blood test. Ideal range is 20-30 pg/mL. If less than 12 pg/mL, bones are at risk. A low-dose E2 patch can rectify that. But 20 pg/mL is a reasonable target IMO, & E2 should be monitored until you are happy with the dosage.

& vitamin K2 (MK-7) should be used to ensure that calcium transport to bone is optimal.

Bone health requires much more than calcium (magnesium, boron, etc., etc.). Calcium supplements can suppress formation of hormonal vitamin D. I'd keep it low if you are not eating plenty of leafy greens. I,000 mg & up is associated with more aggressive PCa.

-Patrick

[Hidden in reply to pjoshea13]

Thanks. I've copied and pasted your reply into a file where I am accumulating the wisdom and suggestions I find on this board. I'll search out that Vitamin K on Vitacost, which has been my go to source for supplements and vitamins.

Ed

[BigRich]

Being on a blood thinner for A-Fib, I am glad you mentioned the work around regarding Vitamin K. The only problem I have with Magnesium is 500mg daily, it would be a problem for me, for I have kidney disease. I did find your reply informative. Thank you for your contribution.

Rich

[BigRich]

"If interested I can explain the work around..." I am interested.

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