could be of interest for those on BAT

[Maxone73]

Extreme responses to immune checkpoint blockade following bipolar androgen therapy and enzalutamide in patients with metastatic castration resistant prostate cancer

ncbi.nlm.nih.gov/pmc/articl...

[OsloN]

It seems that PD-L1 is upregulated as well as in Enza, but also BAT. Number of patients are few, but the response rates in this subgroup at JH may not be just a coincidence. I have BRCA2 + ATM, and now I am on BAT + ARSi following STEP-UP.

Merck donated Avelumab, interested to see the result. I will start on Avelumab when the current treatment no longer works.

[Maxone73 in reply to OsloN]

You contacted Merck directly??

[OsloN in reply to Maxone73]

No, the MD did - showing them the extreme responses after BAT with BRCA2 and ATM

[Maxone73 in reply to OsloN]

I am ATM as well!!

[KocoPr in reply to OsloN]

Hi Olsen, i have a few questions on your bio.

Bio

G9, Enza 12 months to CRPC, Olaparib 18 months PSA nadir 0.11, BAT 04, 05, 06 2023,

PSA 2, 3, 3.4 - the Enza again, PSA dropped to 0.14. Currently 0.5, new round of BAT-ARSi, add Ola in the T-L phase.

————-

What is meant by BAT 04. 05, 06?

The other question is you said add Ola during T-L phase. Do you mean low T phase?

I started Ola on my high T phase. I could only do a week of it instead of my whole two week phase as i was wiped out from fatigue from it. So i will continue Ola on next high T phase for just the one week.

[OsloN in reply to KocoPr]

April, May, June - T Cypionat.

I use Ola contineously during the BAT period, 50 % dosage, no SE.

[KocoPr in reply to OsloN]

50% is what 300mg/day?

I am doing 150mg twice a day

[OsloN in reply to KocoPr]

Yes

[KocoPr in reply to OsloN]

Your doing great on BAT. Looks like your enza got another round from BAT! Thats excellent.

[KocoPr]

Thanks for that Max! It can also be injected subcutaneously so one can self administer. Since im doing my own BAT with testosterone propianate and still hormone sensitive with a RAD50 mut (VUS; Variable of Unlnown Significance) in the BRCA family and a somatic MSH6-LOSS, I would have to peruse this myself.

[Maxone73 in reply to KocoPr]

Can't even put earrings on my wife's ears, or inject my (big tribe of) cats and dogs when the vet tells me to (thanks god my wife can do it)....can you imagine me doing that to myself?

[KocoPr in reply to Maxone73]

Watch you tube videos of it. It is wicked easy.

[j-o-h-n in reply to Maxone73]

Easy Peasy, just go to a Jeweler who advertises "Ears pieced while you wait"....

Good Luck, Good Health and Good Humor.

j-o-h-n

[Ramp7]

This may be an avenue for the next step for me. Thank you!

[Maxone73]

it’s not that I don’t know how to do it! Or that I am afraid of pain (could not be after that damn biopsy) it’s a phobia 😀😀