More promising work on the horizon. CAR T cell treatment.

[kreg001]

Recent review in Nature. And, Google reveals at least one clinical trial at City of Hope. FYI.

cityofhope.org/physician-ne...

nature.com/articles/d41586-...

[Hidden]

I know its only an animation on the City of Hope website, but it was very satisfying to watch those t cells zap the cancer cells.

[tango65]

It may work for some patients. It could have significant treatment related adverse events.

bloomberg.com/press-release...

CAR T CELLS PSMA 101 trials are recruiting being in several places around the USA

clinicaltrials.gov/ct2/show...

[CAMPSOUPS in reply to tango65]

I think out of 9 men in the trial 3 had experienced cytokine release and it was "manageable" ?

Was there some "work" in this area previously and cytokine release was more severe? For some reason I think I read that.

In this current trial "chemo pre-treatment is given" and mention of "All patients received a lymphodepletion regimen consisting of 30 mg/m2 fludarabine + 300 mg/m2 cyclophosphamide.'"

[Javelin18]

The Nature article refers to the success they had with a type of leukemia. I thought it was interesting that the modified T cells stick around for years.

[tango65]

onclive.com/view/car-t-cell...

[dentaltwin]

CAR-T of course has had greatest success with hematologic cancers; there are promising results from CAR-M (chimeric antigen receptor macrophage ):

pennmedicine.org/news/news-...

[Bjry in reply to dentaltwin]

An Australian company Chemerictherapeutics.com works with City of Hope and Penn; prostate cancer is in their pipeline. See chimerictherapeutics.com/ou...