Hello everyone: I had an orchiectomy in mid May, which was just about the time I was supposed to get my Lupron depot at 4 months cycle. I am on Abiraterone as well, and prednisone.
I am surprised that all of a sudden my ham string muscles are stronger and it's quite a bit easier to get up off the floor
Has anyone else noticed the leg weakness as a side effect of the lupron? I always assumed it was the abiraterone that caused the leg weakness. Thanks.
Not sure about Lupron, others can answer that. But don't discount the effects of Prednisone, I've dealt with massive doses for extended time for non-PC disease. It interacts with other drugs and your body in sometimes almost unpredictable ways. Loss of muscle mass and strength is a commonly listed side effect. Four years on/off then many months on high dose let me experience most of it's tricks.
No its the lupron....i have littrraly lost half of all my strength...cannot get up off floor without a hand or aid...sucks
I’ve been on lupron for over 5 years and I swear my leg muscles and strength have about halved and I have been thinking about orchiectomy for a while now think I might ask my oncologist in August when I have a appointment. So do let us know how things proceed.
I think Lupron is the culprit....my legs suck.....
BTW Can you tell us more about yourself: age? location? treatments? Psa and Gleason scores? Treatment center? doctor's name(s)? All info is voluntary, but it helps us help you and helps us too. Thank you.If you wish to reply please do so on a future date and Not directed to me.
Good Luck, Good Health and Good Humor.
j-o-h-n Sunday 06/30/2019 5:22 PM DST
Yes I will give my details shortly. I know when lupron started and the zytiga, and of course my cancer details; just want to look at records I kept about running and when muscle failures started. And, I'll see how my running goes now too.
Thank you kind sir.... No hurry.... just so we can help you...
Good Luck, Good Health and Good Humor.
J-o-h-n Sunday 06/30/2019 11:21 PM DST
So. It's the lupron that makes it so hard for me to get back up off the floor? Another piece of the puzzle.
It has been 2 months since my Orchiectomy, and 5 months from my last lupron shot. My legs are feeling much better and stronger. I don't have any weakness getting up off the floor anymore. Plus, my legs muscles don't fail during runs (1 mile at a time now). But exercise is still quite fatiguing, I presume due to the loss of testosterone, and the Zytiga. I have been a bit depressed lately, dwelling on life's changes.
My specifics:
Age 60
Dx: 9/2018; Stage 4, Gleason 8, PSA initial 25, 12 of 14 cores positive, SV invasion, a few lymph nodes; bone met in pelvis.
Treated at Kaiser Portland, Interstate Oncology.
Current meds: Zytiga, Pred., Losartan, Flomax(max dose). SABR: Prostate 5500cGy/20, Pelvic met: 2700cGy/3.
Hi Marc_ee
Side effects from cancer treatments vary a lot for different men depending on age and fitness and the "unknown unknowns" 
I have had ADT since 2010, after Dx 2009, Gleason 9, 9/9 positive samples, and inoperable, but low Psa at only 6. No mets were found until 2016 when ADT began to fail. I had salvation IMRT to PG and 2 mets in lymph nodes. I had
a procession of drugs, Cosadex, the Zytiga, Psa went up / down up down and then chemo then Psa went up-up and then I quite after 5 shots, Psa halved. I had countless soft mets and bone mets, then began Lu177 last Nov, finished 4 x 8 week cycles in June, Psa now 0.57.
Aches and pains along the way occurred, muscle cramps on early ADT.
But since 2009, and all through my Pca treatment I've cycled about 100,000km, or 220km average a week to stay fit. I'm 72 now, and a hip went bad last April, so I had to quit the bike. But no hip pains or any other pains now so when weather warms I'll try to get back on bike because maybe hip has healed itself. I did have both knee joints done in early 2017 during lull in Psa and within 3 months I was back cycling real well, and guys I used to ride with said I must have a secret rocket up me arse to go that fast. Docs said I was the healthiest stage 4 patient ever seen at their hospital. Wooee. But I could relapse soon, die soon, Hoo Noze?
I eat mainly vegetables, small amounts, and even while not doing anywhere near enough exercise this winter like I used to, weight is not rising. BMI 25, waist < 95cm, resting HR 55. No other obvious problems except the darn Pca lurking now, but it still may kill me. Such is life without a wife, someone said.
I am not a needy man, and get by quite OK without a dame, sun is shining today, Nature has allowed me to stay alive, and have a better life than maybe 6 billion other folks, so I is grateful, tanks Nature.
Patrick Turner.
Hey Patrick, I visited your website this morning. I am retired now, but I was an electronics engineer (but worked in the computer systems field). I saw your log graphs of psa and was really impressed (just, wow!) And your work with electronics, the tubes....
I am starting to bike a bit again. I have a surly long haul trucker with front and rear surly racks and the bike really looks good. Last summer I actually fractured my pelvis by slipping off the pedal and nailing the site of my metastasis.... Didn't think much of it but had to sit on the bike differently for the rest of the summer, and take daily ibuprofen. I seem all healed now, but always have pain similar to one or two toothaches in that area.
I too did orch 9-16 .. glad I did no more shots . Keep active & live well friend 😎
Thank you my brother. And thanks for the link to the song as I want to learn to play and sing that.
Record it and post it . I want to hear . I’ll sing back up for you ..
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