New here. I have been fighting PC for 8 years. Dec 17, PSA rising and bone scan showing mets, one major. Immediate orchiectomy, PSA dropped to non detect (say zero). Large meta radiated. Sept 18 PSA-0 started zytiga. After 6 weeks liver issues , reduced Zytiga by 25%. Bone scan Jan 19 no metastatic disease. My question is why the Zytiga? PSA has remained at zero since dec 17. Sytiga is aimed at castration resistant tumors and the mets disappeared since Dec 17. (hurray) Zytiga is killing my energy!
Thanks
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sandbergc9
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I had orchidectomy 8 Years back. Was treated on and off with ADT. I don't think any ADT including Zytiga and Xtandi work after Orchiedectomy. If still localized you may opt for Radiation which also I had, to good effect. Zytiga and Xtandi are very debilitating and fearfully expensive. With doubtful positive contribution.Tall_Allen is most usually right, please wait to see if he responds.
It is a mistake to think that you have no mets just because you can't see them. You have to treat what you can't see. Zytiga improves survival in all men with metastases, whether one is castration-resistant or newly diagnosed. In fact, it improves survival more when used earlier.
i had a very informative conversation with my urologist that i had just changed over to. he told me ( which i had reds on line) the longest time with zyriga could give me 3-5 years but he's telling me maybe wks. for me why would anyone fight for the cost of zytiga for wks to me its not worth it. were switching to calcium, and vitamin d3 plus at least is looking for alternative meds even some us for women nd some kind of mappying.
zytiga use to cost 10,200 per month for zytiga per month. since i'm not rich i found a foundation that will cover my cost of the zytiga some times a month 6 months or a year. they now have a generic zytiga its a cost of only $8,000
Adding zytiga to primary ADT (castration) has shown increased survival in 2 important trials:
Zytiga is part of the standard of care for patients with metastatic hormone sensitive cancer. In this population it has a significant effect in survival when compared with ADT only. I am not aware of data about intermittent ADT+Zytiga. In general Zytiga is used until failure or intolerance by the patient.
While the majority respond similarly, we also can respond differently. Often casodex is used at the beginning of ADT in conjunction with starting something like Lupron. It helps prevent a testosterone flare which is a common reaction to starting the Lupron. I took it for 2 weeks then Zytiga after that. There are some here that I've read stay on Casodex too. Each patient/regimen is tailored to suit the individual patient.
I am on Lupron and Zytiga following rounds of chemo, Brachy, and direct beam radiation therapy. The Zytiga eventually seems to amplify the side effects of Lupron. But when those side effects get increasingly bad, my doc allows me a break from the Zytiga. A week off can do wonders. Then I go back on. I'm supposed to be done with Zytiga in April. I'm hoping this will keep that PSA where it's at now...undetectable.
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Zytiga did not Work - Chemo or RA 223 Next
What you know might help me
Disappearing Mets 
Zytiga and PSA
Advice needed please.
