Zitga needed?

[sandbergc9]

New here. I have been fighting PC for 8 years. Dec 17, PSA rising and bone scan showing mets, one major. Immediate orchiectomy, PSA dropped to non detect (say zero). Large meta radiated. Sept 18 PSA-0 started zytiga. After 6 weeks liver issues , reduced Zytiga by 25%. Bone scan Jan 19 no metastatic disease. My question is why the Zytiga? PSA has remained at zero since dec 17. Sytiga is aimed at castration resistant tumors and the mets disappeared since Dec 17. (hurray) Zytiga is killing my energy!

Thanks

[3putt]

Welcome to the site. Question - are they starting you on Zytiga after you had an orchiectomy?

[sandbergc9]

Orchiectomy Dec 17. PSA zero since. Zytiga Sept 18. So my big Q is since PSA zero and mets gone, why the zytiga, which is for castration resistant PC.

Yes

[Shooter1 in reply to sandbergc9]

Also kills micro-mets.

[drsridhar53 in reply to sandbergc9]

I had orchidectomy 8 Years back. Was treated on and off with ADT. I don't think any ADT including Zytiga and Xtandi work after Orchiedectomy. If still localized you may opt for Radiation which also I had, to good effect. Zytiga and Xtandi are very debilitating and fearfully expensive. With doubtful positive contribution.Tall_Allen is most usually right, please wait to see if he responds.

[Tall_Allen]

It is a mistake to think that you have no mets just because you can't see them. You have to treat what you can't see. Zytiga improves survival in all men with metastases, whether one is castration-resistant or newly diagnosed. In fact, it improves survival more when used earlier.

[sandbergc9 in reply to Tall_Allen]

OK thanks for your thoughts.

[charlesmeyers1964 in reply to Tall_Allen]

i had a very informative conversation with my urologist that i had just changed over to. he told me ( which i had reds on line) the longest time with zyriga could give me 3-5 years but he's telling me maybe wks. for me why would anyone fight for the cost of zytiga for wks to me its not worth it. were switching to calcium, and vitamin d3 plus at least is looking for alternative meds even some us for women nd some kind of mappying.

charlie

[billy1950 in reply to charlesmeyers1964]

Charlie,

Are you still doing zytiga? How are you doing...

[charlesmeyers1964 in reply to billy1950]

yes until my foundation has run out then most move on to something else

charlie

[billy1950 in reply to charlesmeyers1964]

I am not sure what you are referring to regarding your ' foundation'...

[charlesmeyers1964 in reply to charlesmeyers1964]

zytiga use to cost 10,200 per month for zytiga per month. since i'm not rich i found a foundation that will cover my cost of the zytiga some times a month 6 months or a year. they now have a generic zytiga its a cost of only $8,000

[Hidden]

Adding zytiga to primary ADT (castration) has shown increased survival in 2 important trials:

STAMPEDE ascopost.com/News/55699

and LATITUDE ascopost.com/News/55700

[sandbergc9 in reply to Hidden]

Thx I read about STAMPEDE not Latitude.

[tango65]

Zytiga is part of the standard of care for patients with metastatic hormone sensitive cancer. In this population it has a significant effect in survival when compared with ADT only. I am not aware of data about intermittent ADT+Zytiga. In general Zytiga is used until failure or intolerance by the patient.

ncbi.nlm.nih.gov/pmc/articl...

[ellie2211]

is zytigia used after casodex? or why would one be used instead of the other?

thank you

[MMMayhem in reply to ellie2211]

While the majority respond similarly, we also can respond differently. Often casodex is used at the beginning of ADT in conjunction with starting something like Lupron. It helps prevent a testosterone flare which is a common reaction to starting the Lupron. I took it for 2 weeks then Zytiga after that. There are some here that I've read stay on Casodex too. Each patient/regimen is tailored to suit the individual patient.

[Hirsch in reply to ellie2211]

casodex blocks androgen receptor..

abi. zytiga diminishes extragonadal testosterone..

casodex blocks effects of the testosterone on tumor..whereas abi along with adt

brings testosterone level down to very low levels..that which is beneficial if one is castration naive.. sensitive.

[charlesmeyers1964]

its a side effect of the drug plus the cost as will

[gleason9guy]

I am on Lupron and Zytiga following rounds of chemo, Brachy, and direct beam radiation therapy. The Zytiga eventually seems to amplify the side effects of Lupron. But when those side effects get increasingly bad, my doc allows me a break from the Zytiga. A week off can do wonders. Then I go back on. I'm supposed to be done with Zytiga in April. I'm hoping this will keep that PSA where it's at now...undetectable.