Enzalutamide plus BIRM any conflict?

[cromone]

My March 2016 diagnosis was T4 N1 M1aGleason 8 and Gleason 9 grade group 4&5

. For the past 32 monthsI have been on 3 monthly ADT injections of Triptorilin and I had 6 infusions of Docetaxel. 17 months ago I started Enzalutamide

My PSA at diagnosis was 78 but since starting Enzalutamide has been <0.1.

I used to walk a lot but the constant fatigue has been getting me down. I thought I might try BIRM to counteract the fatigue.

At my last meeting at my local oncology clinic I asked if they new of any conflict with my existing medications, I was referred to the pharmacist who had not heard of BIRM but said she would look into it. She eventually responded by email.

"Unfortunately I can’t find enough information on the pharmacokinetics of BIRM (how it is metabolised, which specific enzymes in the body metabolise it) to determine if there is an interaction with enzalutamide or not. As such, I wouldn’t recommend taking it.

"

I had emailed her a link to the NCBI report on BIRM which I had found on this site which I had found too complex to understand.

Can anyone advise.

[Tall_Allen]

Wise pharmacist! What is the link?

[cromone in reply to Tall_Allen]

ncbi.nlm.nih.gov/pmc/articl...

[Tall_Allen in reply to cromone]

That's a mouse study. if there are clinical trials going on, you may want to wait for some safety data in humans.

[cromone]

Thank you very much for your responses gentlemen.