Does this look like a viable source of the benefits of BIRM in tincture form?
BIRM is an aqueous extract of dried roots of an Ecuadorian medicinal plant, Kalanchoi gastonis-bonnieri. BIRM is extensively used in Western Hemisphere mainly as Herbal immune booster, as by the manufacturer (Ecua-BIRM Inc., Quito, EC and on their website [WWW.EcuaBIRM.Com]. In addition, as per the manufacturer of BIRM, this product has been dispensed as a complementary medicine for ailments such as AIDS, lupus, arthritis related psoriasis and various treatment-refractory cancers. However, the mechanism of BIRM action and whether it is a cancer chemopreventative is unknown. We previously reported anti-tumor activity of BIRM against prostate cancer models, and have shown that it inhibits proliferation of all PCa cells, induces apoptosis and inhibits extracellular matrix (ECM) degrading enzyme, hyaluronidase . Further, we showed that BIRM inhibits tumor growth and metastasis of Dunning MAT LyLu rat prostate tumor with no observable adverse effect. The mechanism of BIRM inhibitory activity against PCa, both in vitro and in vivo, has opened a new avenue for us to investigate the mechanism of anti-tumor activities of BIRM.
Kalanchoi gastonis-bonnieri. tropilab.com/kalanpinnatati...
The Bufadienolides in the leaves have antibacterial, antitumorous, cancer preventative, and insecticidal actions. These isolated compounds isolated include bryophillin A which showed strong anti-tumor promoting activity, also included are bersaldegenin-3-acetate and bryophillin C.
Bryophyllin compounds have marked anticancer therapeutic value against cancer cells. Bersaldegenin-1, 3, 5-orthoacetate inhibited cancer cell growth on several cancer lines.