I have been on antiretrovirals / protease inhibitors (ritonavir. saquinavir, norvir) for many years with excellent results.
Recently I was diagnosed with aggressive PCa and have been on Zoladex for 4 months. My doctor is considering augmenting that with bicalutamide to reduce PSA levels as I await radiation therapy (TE is already <0.1 but PSA appears to be not fully responsive).
The problem is that norvir (at least) slows metabolism of Bicalutamide (and possibly other PCa drugs), thereby slowing their elimination from the body and increasing concentrations and potential side effects.
I wonder if any of you have encountered this situation, and what potential work-arounds were applied.
Thanks to all.