Hi All...I'm learning a lot from your previous posts. Thank you! Thus far, Metformin and/or Berberine seem to be worthy of further consideration. Although there does not appear to be convincing scientific evidence of their effectiveness for PCa patients (absent diabetes), both your reported experience and the low cost suggest at least a trial use.
Like others, my MO quickly dismissed Metformin with "metformin has been and is being studied as an anti-cancer treatment but is not proven and is not standard of care or something I would recommend at this time" -- even though I argued that I've long been "pre-diabetic" with fasting glucose consistently around 100 (95-105) for years despite multiple glucose control supplements and a low carb diet. How have others managed to work around their unsupportive MO and does doing so sound reasonable with or without ADT?
Berberine, as a natural alternative, sounds appealing. What dosages and brands have others found helpful? And any sense of the relative effectiveness compared to Metformin?