Lupron and Metformin: Hey gang...I'm... - Advanced Prostate...

Advanced Prostate Cancer

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Lupron and Metformin

bean1008 profile image
39 Replies

Hey gang...I'm not sure if it's all the holiday treats or that I'm six weeks into my first shot of Lupron but my blood sugar has gone up. Normal fasting glucose is around 115-120 but lately it's been 140-150. I'm now taking four 500mg Metformin ER at dinner...dosage used to be three...but still seeing the elevated numbers. How do you diabetics deal with your disease when on Lupron?

Thanks and happy holidays!

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bean1008
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LearnAll profile image
LearnAll

It is very very common to see worsening of diabetes in men who are on Lupron. Increased blood sugar can be countered by adjusting dose of Metformin and reaching to ideal body weight ..BMI of 24 or less. This can be accomplished with strong lowering in the caloric intake and avoid all high calorie dense foods along with frequent physical activity all day long. This article may provide more understanding about connection of Lupron and Diabetes.

acsjournals.onlinelibrary.w...

CINNAMON spice can help somewhat with both PCa and Diabetes.

bean1008 profile image
bean1008 in reply to LearnAll

Thanks for the link, LearnAll! Working on the BMI...so easy to gain but so hard to lose!!

MateoBeach profile image
MateoBeach in reply to LearnAll

... and everything nice. Just don’t try a teaspoonful of cinnamon. 😆. Want to thank you LearnAll for all of the great informative posts and ideas you have given me (us) this year. All the best to you.

LearnAll profile image
LearnAll in reply to MateoBeach

I too do not like taste of Cinnamon...I found a way..I have capsules filled with Cinnamon powder 2000 mg /2 caps from Nature's Bounty brand. This is much better then trying to tolerate taste of Cinnamon. Thank you for thank you.

See more info about cancer cell killing effect of Cinnamon-

pubmed.ncbi.nlm.nih.gov/329...

bean1008 profile image
bean1008 in reply to LearnAll

Thanks for the info on cinnamon, LearnAll! Really interesting!

KJMinPhx profile image
KJMinPhx

You got it right. I Had been on metformin prediagnosis but a few months of Lupron +p and Zytiga made my sugars rise. Dr doubled the dose. Seems stable now.

bean1008 profile image
bean1008 in reply to KJMinPhx

Great info...thanks KJM!!

Kaliber profile image
Kaliber

Yes Lupron can cause “ drug induced diabetes “ , it’s one of the diagnosis on my illness list at Kaiser. I’ve been taking more metformin and adding glimepiride to boost the metformin. I was taking 500mg and they jacked it up to 2000mg. Unfortunately, I’m not tolerant of that much metformin and have been experiencing about 7 months of unpredictable uncontrolled explosive diarrhea at first. We’ve been juggling my meds, changing to time release pills etc ... now I’m taking 500mg time release metformin and 1mg glimepride and have a semblance of control. I was having A1C readings in the 6.3 - 6.7 range (/bg 120-150 range ) ( with 2000mg + glimepiride ) but life wrecking explosive diarrhea. Now the docs say if I can just keep my daily bg readings under 200 , on average, they will settle with that. That would be a A1C of about 8,5. Of course if you can adhere to a strict keto diet , you will need far less metformin to have a A1C under 7. I’m late in my PCa diagnosis and escaped hospice 25 months ago. I have to balance the unpleasantness and strain that a keto diet brings to my life against my QOL for my remaining time left. If I won’t eventually benefit from keto’ing myself in the long run , why do that to myself ?

You’ll want to talk to your docs about glimepiride most likely.

Just say’in 💪💪💪👍👍👍

treedown profile image
treedown in reply to Kaliber

Seems like it comes to what will take us down first the PC or the treatment.

Kaliber profile image
Kaliber in reply to treedown

No kidding yayahahahaya 💪💪💪👍👍👍❤️❤️❤️

bean1008 profile image
bean1008 in reply to treedown

That's for sure...it all keeps compounding, doesn't it? I just want enough QOL that I might do some traveling to see the places on my bucket list before I kick the bucket!

bean1008 profile image
bean1008 in reply to Kaliber

Thanks so much, Kaliber! The battle is ongoing, right? Will mention the glimepiride to my doctor. And since I went up to 2000mg maybe that explains my adventure with the sudden explosions and gas! I've been lucky so far but there's been a couple of times where the unstoppable urge was barely contained! Best wishes to you!

Kaliber profile image
Kaliber in reply to bean1008

Yes exactly ... same here, Ive had some unexpected nasty accidents too. I sit on a large heavy plastic garbage bag in my truck when driving and carry a porta potty setup in the back. Several changes of clothes and handy wipes yayahahahaya yayahahahaya it’s always something.

💪💪💪🌈🌸🌼🦋🌻❤️❤️❤️

Cleodman profile image
Cleodman

I don’t think that you should look to medicine to fix the problem when you already know your problem is your diet. Decrease your sugar intake and try your best to exercise for 30 minutes 5 times a week. Bet after 1 month you will be golden!

bean1008 profile image
bean1008 in reply to Cleodman

Right, Cleodman! Our peleton bike arrives next week and I hope to drop 20-25lbs. Going to get back into fighting form! 👍

Cleodman profile image
Cleodman in reply to bean1008

I have no doubt that you got this bean1008!

NRH_Beach profile image
NRH_Beach in reply to Cleodman

I agree that medicine should not replace a diet/fitness program, but you are not showing empathy - or awareness - of the needs if those who come into this battle with metabolic syndrome/pre-diabetes.

noahware profile image
noahware

As others have suggested, the diet is going to be more important than the meds in controlling blood sugar. And it sure is tough for some of us, from Thanksgiving through New Year's!

Aside from reducing overall carb intake, consider also moving from higher glycemic carbs to lower glycemic ones (steel-cut oats instead of bread/cereal, berries instead bananas/grapes, etc.) as well as time-restricted eating (nothing more to eat after the sun sets, for example).

It's all about the carbs, but type and timing as well as quantity.

LearnAll profile image
LearnAll in reply to noahware

Good suggestions about type of diet. Prostate cancer cells utilize amino acids and fatty acids in beginning part of illness....(at least in first 2 to 3 years) But the cancer cells as they grow more abundant and form colonies with their own blood supply.. learn to utilize glucose. Lot of people get confused about this because in many other cancers , glucose use is from the beginning...but its not so in case of prostate cancer cells.Avoiding eating Animal proteins and Animal fats reduces proliferation of prostate cancer cells/

Eating Lentils, Vegetables and Fruits does not cause any problems until PCa gets into terminal final phase. Of Course, people with Diabetes needs to minimize high glycemic index carbs.

Go to YouTube write "Does Sugar Feed Prostate Cancer" Dr Mark Scholtz explains it beautifully.

noahware profile image
noahware

Trolling again?

noahware profile image
noahware

I am not on keto, but definitely on the bandwagon. Since you mention it, keto is one of the best ways to reverse T2 diabetes and insulin resistance (and very useful for losing extra pounds of fat, too).

The reason I did not mention it here is that it is a pretty strict and radical approach to eating that many men, including myself, find either difficult to maintain or less enjoyable than more "normal" eating, or both.

The direct benefit for PC is a matter of debate. For losing weight/fat and improving blood sugar, though, it is pretty much slam-dunk effective if done right.

Kaliber profile image
Kaliber in reply to noahware

I’ve had weight issues for decades. I attended weight clinics that gave you “ diet pills “ for 10-12 years and they worked, but my bp started to become an issue and I had to quit those. After a lot of different trials I discovered that keto worked very well for me. It allowed me to stop taking both heart meds and bg meds..... and I was able to manage my weight pretty well. In my case keto, although difficult at first , worked very well. Snacking on any meat and cheese was great for a while too yayahahahaya Then my health collapsed and I discovered I had hospice level PCa. Looking back I can’t help but having that nagging suspicion that 20 years of keto screwed with my body and was instrumental, somehow, in causing such vast cancer proliferation in me. I’m sure there is no way to know, still I can’t help but wonder.

Just say’in 🦋🌻🌸🌼🌈

noahware profile image
noahware in reply to Kaliber

I think some forms of keto are probably more healthy than others, whether with regard to PC or other ailments. The healthiest versions are probably the hardest to stick to: restricted calorie, intermittent fasting, low dairy, low meat, high in omega-3 fatty fish, mostly green leafy veg + avocado + olive oil, etc, etc. ?

Kaliber profile image
Kaliber in reply to noahware

Probably right .. mine was the standard ole keto ... still worked perfectly ... it’s impressive if you stick with it. Hev e a great Christmas Eve brother ..

noahware profile image
noahware in reply to Kaliber

Thanks, you too!

maley2711 profile image
maley2711 in reply to Kaliber

Were you having regular PSA checks before PC diagnosis?

Kaliber profile image
Kaliber in reply to maley2711

No, if I had been they would have saved me from stage 4 advanced

bean1008 profile image
bean1008 in reply to Kaliber

Same here...my first PSA was not until I was 60. I hear the US federal recommendation is finally changing. Wish I could sue the bastards...mine was found too late.

Kaliber profile image
Kaliber in reply to bean1008

I hear that 👍👍👍

beogradjanin profile image
beogradjanin

My sugar is ok, but as a complement to Xtandi therapy and LHRH, last month I added 580 mg daily of Metformin, and have intension of double it these days, plus added 20mg of Statin.

mrscruffy profile image
mrscruffy

I eat and train like a body builder and that seems to help immensely for me. I also believe Prednisone helps with that

OldFart81 profile image
OldFart81

Hello bean...your dosage is correct but your usage is wrong.

Even if your pills are ER, what you really want to do is take your MetF in concert with your meals. I've been on 2,500mg of Metformin for 15 or so years...like this:

500 before breakfast, 1,000 b4 lunch, 1,000 b4 dinner. Makes sense if your two heaviest meals are lunch and dinner. If you have a heavier breakfast and a lighter lunch, switch the two doses to 1,000 breakfast and 500 lunch.

MISC NOTES:

1 -- My calorie intake is averaging 1,500/day. (I also take 2mg Repaglinide aka Prandin with heavier food intake.) You'll only want Prandin if your A1C is over 7.0. My A1C last week was 5.4.

2 -- Your pharmacist may have trouble with the Rx because it's 2 different pills. You can solve this by asking your doc to issue 2 scripts, #1 for 500 mg, and #2 for 1,000.

I hope this helps. Stay safe during this hectic season of HOPE.

bean1008 profile image
bean1008 in reply to OldFart81

Thanks so much! My doctor and I had talked about changing up the time of day that I took my pills and after reading your suggestion I’m going to give it a go! Best wishes to you!

OldFart81 profile image
OldFart81 in reply to bean1008

Good 4 U. I wish you great success and a Happy, Safe New Year!

MateoBeach profile image
MateoBeach

Lots of diet perspectives here Bean. I went ketogenic a year ago with intermittent fasting. A bit of effort up front to learn about it and get started. Then when in ketosis it is easy and great to have unlimited energy as you burn body fat, lose wait effortlessly. No hunger pangs at all. Glucose and lipids improve. Eat as much as you want afternoons and evenings. Just keep the carbs very low. Very easy for meat chicken and fish eating omnivores. Kicks butt on type II diabetes and pre-diabetes. Get “The Ketogenic Bible” or see free levels of websites such as DietDoctor.com

bean1008 profile image
bean1008 in reply to MateoBeach

Thanks Mateo! Tried going keto many years ago and it worked well for me. Probably time to make some diet changes...I love them but know that carbs are not my friend. Best wishes to you!

Kaliber profile image
Kaliber

Well thanks brother..... I’m just playing cancer whack-a-mole . Hopefully most of you guys won’t have to play this game .... it’s the schitts ( yayahahahaya) ... yuck.

I’m determined to make my lemons into lemonade.

🌻🦋🌸🌼🌈🌈❤️❤️❤️

Kaliber profile image
Kaliber

💪💪💪👍👍👍❤️❤️❤️

bean1008 profile image
bean1008

Thanks XPO1! Actually I did not know that but it makes sense. I read recently that you need ‘impact’ aerobic exercise. My jogging days are over so I’ll be searching for an alternative. I appreciate hearing from you...best wishes!

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