CR to zytiga and xtandi. PSA went from 3 to 290 in last 4 months. Had 4 bone mets and 22 rounds of radiation that just ended last week. In two weeks I start taxotere. Does anyone know what I can expect from the taxotere? Chances of working?
taxotere may be last thing left - Advanced Prostate...
taxotere may be last thing left
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truckerbob
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Wow, you've been through some tough times already. I did not have too much problem with Taxotere. My hair fell out, fatigue was worse. Nausea and vomiting weren't bad. I only did five doses because my PSA increased steadily. I tried RAD223 next and that made me pretty sick and my PSA increased even more rapidly. Taxotere is often very effective but not always
I recommend that you start talking about what constitutes successful treatment. From here you may begin to struggle with how long to continue treatment that may not be completely successful. you may want to talk with MD and you family about several next steps.
Do you have a good pain management plan? I'm guessing you've got some significant back pain. I wish the best to you.
I just finished up 13 treatments of taxotere. I was able to tolerate it fairly well and after experiencing the side effects, I'd anticipate them in advance as much as I could in order to minimize the negative consequences of the side effects. For the most part this worked except for the fatigue. The Chemo has managed to keep the PSA from going up and with the Bone Scan and MRI that I had at the end of the 13th treatment my bone mets have not changed significantly. I am on a Chemo Holiday right now because I was highly toxic after 13 treatments. So far in the 6 weeks I've been on the Chemo Holiday my PSA has only gone up slightly. In two weeks I go back to my oncologist to evaluate where I at. I'm expected from earlier discussions that I will need to go back on taxotere again or switch over to Jevtana.
Good Luck
Dennis
Dennis,
I just met with my team today, and am real close to where you are. My PSA has been slowly bumping up the last 4 of now 10 cycles. Today up 6% again.
I am heading for scans after round 11, and they say if no soft tissue or node mets - which I have not had, then we do 223.
If node mets, holiday then Jevtana.
I was wondering why you didn't go the 223 route after Docetaxel?
Peace
Greg
I'm on a Chemo holiday right now. I go back to my Oncologist next week. At that time we will talk about options that are available. He indicated that the next step for me when the taxotere stops working would be Jevtana. The taxotere was still working when I went on the Chemo holiday so it is possible that I may go back on that drug. The bone mets that I have, have not changed in 4 years and do not cause any pain. I have a couple of my lymph nodes that are cancerous, which is probably why my Oncologist is recommending jevtana next. The 223 would do nothing to help me with the lymph nodes.
got ya. Thanks
When you state above that you are "highly toxic" can you please explain what that means? I am 10 rounds in, and my MO has told me that 12-18 rounds is all they will do consecutively before taking you off - due to the damage the chemo does long term to the body, and explained zero about the specifics of the effects. So, what do they mean by "highly toxic"?
Thanks ahead of time for your response.
The taxotere builds up in your body with each treatment. I could really tell by the 12th and 13th treatments. By the 13th, the side effects got so bad that I thought I would almost be better off dead. The rash that I usually get actually looked and felt more like a bad sunburn on my hands and neck. I slept one day for about 22 hours with little energy the rest of the time. And my feet we swollen up to the point I couldn't get most of my shoes on. I've been on the Chemo Holiday now for about 2 months and am feeling great. So far my PSA has only slightly gone up. Next week we'll check it again to see where we go next. All of the side effects have disappeared.
I was also on Zytiga. Now I'm on a taxotere (docetaxel), I'm getting 4 doses on Friday. I tolerate it quite well. I have a little problem with white blood cells. And the second problem is that I'm more tired. The worst is the first five days after the application, then it gets better before I get the next dose. The positive thing is that my pain has stopped in my hip and leg.
Make sure you have your white blood cell count checked. Mine went really low and they had to put me on Neulasta. On the positive side, my PSA went from 70 to 1.
Bob,
You refer to "Last Thing Left". That is pessimism and not justified. What about ADT? Lupron, Casodex before the Zytiga and Xtandi?
Your history does not cite any complementary medicine strategies. Few persons posting here do mention natural supplements that are compatible with their chemo or ADT treatments. Here is a post of mine that contains responses from community members who have tried natural supplements (esp., IP6 and Beta Glucan) to help in the battle.
healthunlocked.com/advanced...
Thanks CalBear74. I am a big believer in complimentary therapies. The one thing that I would like to try is Hyperbaric Oxygen therapy along with IV Vitamin C therapy. Unfortunately my doctors at Memorial Sloan Kettering don't believe in it. Maybe I'll invest in an HBOT chamber for myself. Thanks for the tips CalBear74
I have never researched HBOT.Good luck!
I have no experience of HBOT but many years ago I tried IV vit C. I did two cycles of two weeks each (5 infusions per week). The first cycle was 125 g per infusion, the second 200g (about the most my doc was prepared to risk). The only effect was a minor placebo effect. A month after, PSA was back where it would have been if nothing had been done. I conclude not of much use to me. Expensive, very painful (those concentrations really inflame the infusion site) during the several hours for an infusion. For someone with your history, BAT (bipolar androgen therapy) may be worth a shot - there's a good chance it may re-activate the Xtandi.
CalBear74... he has probably exhausted all of the ADT therapeutics. I was never given proscar or adovart...my med onc stated that ADT therapy was no longer an option due to PSA rise while on Xtandi. So again he is prob out of options like me except for chemo and I'm not doing that again.
It distresses me to hear PCa patients say there is nothing left. Perhaps nothing in conventional oncology drugs: ADT, chemo, etc., but that is constantly changing. Also, in complementary medicine I have read Shamsuddin's book and I am familiar with R. Agarwal's research at the Univ. of CO=Denver. Here is a sample of his work on IP6 (aka "inositol hexaphosphate", Phytates. phytic acid) The other links will help.
ncbi.nlm.nih.gov/pubmed/195...
amazon.com/IP6-Inositol-Nat...
Here is Dr. Greger's summary of the IP6/phytate successes in treating prostate cancer.
nutritionfacts.org/video/ph...
I was reading Shamsuddin's book and his summary of Agarwal's contributions. Not the first time I had read it. They both have done some amazing lab work on in vivo and in vitro tests of IP6.
CalBear74
I understand what you are saying. I am also trying alternatives ...but I watched my dad die from this...he was 63... so... I know what's ahead. It's a horrific way to die. So...until someone finds a way to completely halt its progression and put us all in a permanent remission...I have a hard time seeing anything else in what lies ahead. Apologies.
Good chance of working. It is working on me right now. I just had infusion 5. After that you can try to challenge the cancer again with xtandi and look at clinical trials for LU177 that are starting up here in the USA. There is one in November at UCLA. If LU177 helps you, you can look at Radium 223 after that to keep fighting that cancer.
Main side effect for me was diarrhea, bottom of feet hurt, fatigue, hair loss, but side effects were not as bad as I expected.
Taxotere was given to me at diagnosis.
Dose was too strong and was in hospital for 8 days with neutropenia.
It did Work vet well on reduced dose.
Now on Zytiga
Radiation has been done
Lupron and Xgeva currently
Also added Xofigo due to increase in Mets
PSA remains low
We are targeting at this point increase in already widespread Mets.
Seems to be working.
I would say the entire treatment strategy has been effective and not just Taxotere.
After chemotherapy, have the doc check your ARV7 Gene to see if Xtandi/Zytiga would be indicated.
Good Wednesday Morning truckerbob,
I have been in this battle for six years (please see bio for complete treatment history).
Completed 6 cycles of Docetaxel/Carboplatin chemo on 1/9/18.
Here are my hints/advice on chemo:
1. Docetaxel can cause peripheral neuropathy, so Med Onc suggested taking 100mg B6 orally daily to mitigate and I iced my hands and feet during chemo. Ended up with tingling/numbness in left foot, not so bad in right foot.
Hands OK.
2. Began each chemo session with an infusion of Aloxi, to prevent nausea, and it worked.
3. Med Onc prescribed Dexamethasone day before, day of, and day after chemo to lessen side effects.
4. Left each session with On Body Injector of Neulasta to boost white blood cells. Med Onc recommended Claritin day before chemo and for 6 more days to reduce bone pain.
5. Used Biotene products for mouth care.
6. Took Wisconsin American ginseng to combat chemo fatigue. Google Mayo Clinic and ginseng for their trial results.
7. Had a chemo port implanted in right upper chest before beginning and it saved my arm veins.
All in all, not too bad. Fatigue is cumulative so as cycles progress, it will take longer to get back to "normal". My chemo was on a Tuesday, so I was fine on Tuesday and Wednesday (because of Dexamethasone), but began to slow down on Thursday and stayed in pjs on Friday. At beginning, I recovered over the weekend. At end, it would take a week to get over fatigue.
Best news is that it worked--lowered PSA from 10.8 to .4 and liver lesions less distinct!
Best wishes. Never Give In.
Mark, Atlanta
Forgot to add a most important result--rechallenge with Xtandi after chemo has been working for past 5 months during my chemo break. Like you, I had failed Xtandi, but chemo reset cancer cells/AR-V7
and by the grace of God, it is working a second time!
Mark, Atlanta
I went through 6 cycles in 2017. didn't miss a day of work, Got chemo on Wednesdays, effects didn't hit until Friday evening, slept until Monday morning. Had to get shots to jump start white blood cells. No neuropathy, I was only 53 so oncologist says that helped being younger...
PSA went from over 300 to 5.
Have you already gone through the casodex/Lupron therapy before going to Zytiga?
Thanks so much guys. I have read every reply and feel a lot better. Yes I went thru casodex- Lupron before I went onto zytiga and xtandi. I am still fatigued and have bad back pain after radiation for the 4 mets. I finally ate today because I was actually hungry. Cant wait to get over residual pain from the radiation at MSKCC and move on to chemo
Hey Bob. Taxotere (along with Lupron) took my husband's PSA to undetectable. A while back I posted a long article on avoiding side effects of taxotere. If you search for it and can't find it please let me know and I'll find it and post again. Good luck!
If its not too much trouble could you find me a link to that article. Thank you TNCanuck
P.S. My husband (58 at the time) worked full-time while going through chemo.
Here you go! This post was originally made by a gentleman on another, similar site. I have not vetted the facts of the post, but can tell you that following the advice regarding minimizing side effects worked very well for my husband. Regarding hair loss, my husband chose to use cooling caps and did not experience any hair loss. Prayers for great results for you!
"TAXOTERE was first approved for the F.D.A. for use in the treatment of prostate cancer in the year 2004. Researchers spent YEARS finding chemotherapy compounds that could attack prostate cancer cells. At that time, TAXOTERE was typically used for advanced prostate cancer, after all other treatments had failed. It was once considered a "Hail Mary" pass in the last quarter of the football game, so to speak --- but certainly a tremendous STEP FORWARD in treatment options !
Things have CHANGED since then, my friends --- new breakthrough medications, used in combination with TAXOTERE, have created an entirely new landscape in the treatment of advanced prostate cancer and TAXOTERE has shifted to an upfront treatment option, rather than a "last shot" treatment option. It has now moved its way to the "front of the line" --- which means that now some fellows get started on a chemotherapy regimen almost immediately upon diagnosis --- often in combination with other medications or treatments.
In more recent times, based on the results of clinical studies such as the STAMPEDE trial and the CHAARTED trial, the use of TAXOTERE has been used MUCH more frequently as an upfront treatment for specific cases of advanced prostate cancer. It's important to note that TAXOTERE is also used as a chemotherapy treatment option for other types of cancer besides prostate cancer, as well.
As a weapon of attack, TAXOTERE has cytotoxic properties that attack rapidly growing cancer cells. Some of the cytotoxic, cancer-killing compounds used in TAXOTERE are derived from California yew trees. Who would have thought that yew trees would become a source for a potent form of defense against various forms of cancer, including prostate cancer ?!! Thank you, research scientists !
Meanwhile --- it's important to know each person's experience with chemotherapy, typically TAXOTERE, can vary widely. Some oncologists are now adding additional components to their chemotherapy blends, such as CARBOPLATIN and other compounds, to address the individual needs of the patient. These are commonly nicknamed CHEMOTHERAPY COCKTAILS, as the science of blending patient-specific chemotherapy mixtures continues to evolve in recent years.
During my chemotherapy treatments with TAXOTERE, I felt fortunate, in that I went to work each day and kept up a full schedule during my treatments, for the most part.
Several of us have banded together on this thread, with a common goal of sharing some of our experiences with chemotherapy in a "one brother to another brother" style ... honest and straightforward. We felt that learning about chemotherapy from other comrades who have been "soldiers from down in the trenches of battle" would provide a factual and honest account of our collective experiences, from a wide range of BATTLE BROTHERS, trusted and true ... from right here on our forum.
With that intent in mind, here are some things that I have learned, from my own first-hand experiences while undergoing a series of chemotherapy infusions, that might give you some insight if you are considering TAXOTERE chemotherapy treatments, now or in the future:
1. HAIR LOSS: Truth be told, fellows ... we'll get right down to it ... it's usually every fellow's first question aboutchemo treatments ... yes, I did lose all of my hair from the top of my head --- perhaps two weeks after my first chemo treatment, which is a common occurrence. However, some of my friends kept some of their hair, while ironically, other friends of mine kept ALL of their hair. So, as you can see ... hair loss can vary widely. Hair loss is quite typical for the MAJORITY of chemotherapy patients, so just be prepared in advance, my friends !
2. BUZZ CUT STRATEGY: When my hair started falling out, it was very SUDDEN. Almost every person who loses their hair reports this sudden phenomenon. My hair suddenly began falling out in clumps one morning in the shower, without any warning ! CLUMPS of hair in the shower drain ! As I continued to shampoo and then dry my hair with a towel ... even more fell out ! I went to work, not quite sure what would unfold next for me ... it soon became clear that even more hair was falling out throughout the work day, even at the slightest touch. MESSY ! What's a fellow to do, right ? Here's a simple strategy that works ... that evening after work, I quickly drove to a nearby barber shop and got a "buzz cut" to help ME make the transition. In the days thereafter, even the "buzz cut" started falling out completely. So ... about a week later, I finally got out my electric razor and used the electric clipper and completely buzzed off the rest ... and I was bald. To be honest, this was a bit hard to deal with at first, as you can lose some social confidence when you lose your hair so suddenly. At the first sign of hair loss, though, getting the buzz cut FIRST helped ME make the transition to total hair loss. If it begins to happen, go for a buzz cut that day. That strategy helped me immensely !
3. SOCIAL CONFIDENCE RESTORED: To help me deal with my hair loss, I just went and bought some casual hats and also a few dress hats --- I used the casual hats for everyday events and I used the dress hats for formal occasions. Having a VARIETY of hats helped me regain that little edge of confidence for social situations at various times. I also bought some winter hats to help me get through the cold winter season. Here in the Midwest region, the winter season is long and cold, so I was suddenly sporting some new stocking hats when winter rolled around. Hair loss --- if it happens, you deal with it, you throw vanity out the window, and you MOVE ON with your life. People DO understand --- they realize you are going through treatments --- they have compassion. When you put it in perspective --- I had always admired the bravery of others who experienced hair loss when THEY were going through medical treatments --- so, I suddenly realized that any traces of personal vanity needed to be put on the back burner --- and I just forged ahead with my treatments. This is a topic that needs to be addressed ... because fellows DO ask, "Does this mean I'm really going to lose my hair?" The truth ... maybe ... yeah, probably ... and you get over it ... with that being said, it's time to move on, fellows !
4. APPETITE: Before each chemotherapy treatment session begins, they give you anti-nausea infusions and steroids right before the TAXOTERE chemotherapy infusions. These components help you OVERCOME some of the side effects that once gave chemotherapy treatments a nasty reputation decades ago. Quite honestly, I did NOT have any digestive problems or nausea, whatsoever. I was very thankful for that ! Chemotherapy has improved in that regard in the past few years. Many of us have learned from personal experiences that it's best to eat properly while going through chemo treatments --- just do your best to stay away from greasy foods, fast foods, and junk foods, overall ... but don't deprive yourself of your favorite comfort foods along the way ! Personal confession ... after every chemotherapy infusion, I always went out to dinner that night at my favorite barbecue restaurant, just as a way to relax after "treatment day" was over ...
5. HEALTHY HYDRATION: An important lesson that I learned from my experiences and other CHEMO COMRADES here have concurred with this helpful tip over time --- drink plenty of water before each TAXOTERE infusion, but also keep drinking a healthy amount of water FOLLOWING each treatment after you get home. Your body needs WATER to deal with the toxins that are infused with each TAXOTERE treatment. Lesson learned - stay hydrated before AND after each chemo treatment. Water seems to be the best "elixir" for so many types of prostate cancer treatments and medications. Another helpful tip, from one fellow to another --- if you need to use the restroom DURING a chemo infusion, they can easily unplug the infusion machine and then you just plug it back in after you return from the restroom. No problem, no worries!
6. CHEMO ENERGY CRASH: A couple of days after each infusion, then you will typically experience what I call "CHEMO CRASH" --- 2 or 3 days after the treatment, usually. Ahhhh, yes ... the "crash" ... as we all call it, is somewhat of a delayed reaction, occurring a few days after a treatment, because of the initial steroids that they give you when you receive each treatment. A few days after each chemotherapy infusion, a feeling of malaise or lethargy is typical. You're going to feel like a car battery that needs a set of jumper cables on a cold winter's morning to get jump-started. I just found that resting on the couch or in a recliner seemed to help me the most. In a day or two, your body will begin to re-bound and your energy will be restored. The "CHEMO CRASH" feeling will begin to drift away. You can expect to feel this sensation after each treatment, but then it fades away and your energy returns.
7. ENERGY RESTORED: For fellows who are still active in their careers --- my oncologist timed my treatments so that my "chemo crash" would hit over the weekends, so that I could keep up my full work schedule. So, in my case, I had my treatments late on Wednesday afternoons and then the "chemo crash" would often hit Saturday evening or Sunday. By Monday and Tuesday, I could feel my energy coming back. Other fellows starting chemo often ask me, "How bad is the 'CHEMO CRASH' after each treatment?" Here is the description that seems to resonate the best with most fellows ... I tell them that it feels like a MILD hangover ... the mild hangover you might have felt in college the morning after a fraternity party, back in the day. Most fellows then say, "Thanks for that description ... feels like a mild hangover, you say ... been there, done that ... thanks for the honest answer, my friend." With that being said, I felt fortunate that I was able to keep working, with just a couple of days of feeling somewhat drained. My work kept me focused --- gave me goals to meet --- kept me grounded. Living your life during chemo --- many of us have found out that it truly CAN be done !
8. NETWORK OF SUPPORT: Chemo can be a ROUGH ROAD sometimes ... I have described it to my other BATTLE BROTHERS as walking down a gravel road in your bare feet on those rougher days when you feel the "Chemo Crash" coming on in the days after a treatment. Yep, gravel road with a few ruts here and there along the way ... admittedly, there can be some rough days, from time-to-time. Overall, I was pleasantly surprised that I WAS able to go to work and keep up with my usual social events and activities. For any fellow beginning chemo treatments ... here's some brotherly advice ... you need some support along the way to stay motivated and encouraged. Best advice, you ask ? Here it is, quite simply ... stay in TOUCH with family, friends, neighbors, work colleagues, church members, and so forth. You NEED people's encouragement and support to get through the weeks and months of chemotherapy. I worked very hard to keep my head in the game, stay involved with friends and relatives, and to keep attending social events. Trying to keep up normal routines also helped me cope with everything going on around me. Chemo can be a ROCKY ROAD at times --- physically, emotionally, spiritually --- you have to keep forging ahead each day --- so do everything you can to keep busy mentally and physically. At the same time, realize that there are times when you are going to need to rest and relax and take it easy on yourself. I sometimes had to tell myself that I couldn't be "SUPERMAN" in a red cape all the time, and that I simply needed to become best friends with my living room couch on some evenings, stay home, and just relax. I've heard of some fellows whose bosses allow them to take a short "power nap" or rest break during the work day, realizing that they are going through chemo treatments. Kudos to those bosses, for their compassion and understanding !
9. FORGING AHEAD: I was fortunate, because I had a couple of CHEMO COMRADES who went through the experience at the same time that I did. We formed a powerful bond of brotherhood and kept each other going --- checking in with each other --- we felt like fellow soldiers, going onto the battlefield together, supporting each other through those weeks and months. Nothing better than a loyal comrade during chemo treatments, fellows ! We still feel a sense of loyalty to each other from that experience. My advice, fellows ... do whatever it takes to find a loyal friend or relative or neighbor or old classmate or work colleague whom you can talk with and confide with during chemotherapy. If nothing else, this forum can serve that function for you ! There's certainly a band of CHEMO COMRADES for you, right here on this forum, ready to support you, encourage you, and advise you. The loyalty and compassion found here on this website is beyond compare ! After I finished chemo treatments, I now have other friends who have been diagnosed and I have volunteered to be their CHEMO COACH, because I know how important it is for fellows in our situation to have a buddy that knows and understands what this is like. Do whatever it takes to reach out and find some connections ! Support --- we ALL need that !
10. STAYING ACTIVE: Well, what about EXERCISE and physical activity ? I found that keeping physically active, as much as possible, also helped me. You don't have to become an Olympic athlete, fellows --- just a walk around the neighborhood for 20 minutes or so can do a LOT to keep you going during the chemo treatments. I also visited the gym now and then. During the winter months, when snow and ice made walking outdoors treacherous, I walked in an indoor location instead. Do whatever YOU like to do --- walk the dog through the park, mow the yard, shoot some hoops, go fishing, run on the treadmill, pedal the exercise bike, work in your garden, lift a few weights, walk for a bit on the nature trail, stop by the gym for a bit --- whatever appeals to you. Maintain a healthy lifestyle and choose good foods to eat and remember to stay hydrated. After one of my treatments, I slacked off on the water consumption and didn't bounce back as well from that treatment, so I learned my lesson on the importance of staying hydrated after each treatment. Eat a healthy balance of foods, stay as active as you can, rest when you need to, and stay hydrated in a healthy way !
11. CAUTIONARY NOTE: My doctor warned me that a fever of 100 degrees or more is VERY dangerous for chemotherapy patients. Your immune system becomes compromised during your treatments, including your white blood cells --- so there is an increased risk of fevers or infections, of course. So, if you experience any sort of fever of 100 degrees or more, get to an emergency room as soon as possible. There's your cautionary lesson for today --- we have some fellows here who HAVE experienced a spike in fever and they went to the clinic IMMEDIATELY, as they should. A few helpful tips to share ... keep your hands washed before eating --- stay away from cold and flu germs, as much as possible. I teach in an elementary school, with hundreds of young students --- so, I used antibacterial soap throughout the day and used antibacterial cloths to disinfect the student desk tops each evening after school. Keep your kitchen and bathroom disinfected at home, as well, just as a precaution --- in the interest of avoiding colds, flu, strep throat, and fever. A fellow "chemo comrade" of mine gave me a new thermometer as a "gift of caring" when I started my first chemotherapy treatment. Sometimes, the clinic will also give you a courtesy thermometer to keep with you at home and work. DO take action if you feel a spike of fever, fellows --- it is NOT something to ignore.
12. ICE CHIPS STRATEGY: To preserve my taste buds, my oncologist always insisted that I chew on ice chips DURING the actual chemo infusions and my sense of taste remained completely intact during all my months of chemo treatments. PLEASE ask for some ice chips before your infusion starts, fellows. It can't hurt, and it sure might HELP ! True story --- I had a friend who FORGOT TO ASK for ice chips and he regretfully lost his sense of taste --- spicy Mexican food suddenly tasted "bland" to him, so he knew he had lost some of his sense of taste and he wished later that he had remembered the strategy of chewing on ice chips during the chemo infusions. During your months of chemo, take GENTLE care of your mouth, as patients are prone to mouth sores. Brush and floss GENTLY, and avoid harsh brands of mouthwash, which can irritate your mouth because of the alcohol content. For the first couple of nights after an infusion, I took an extra shower, because you can almost feel the chemo "sweating out of your pores" at night for the first couple of nights. If I woke up in the night, I drank some more water. As the weeks of chemo treatments went on, I noticed that my face looked a little "puffy" due to the steroids that they give you before each chemo infusion to help your body tolerate the chemo. This is sometimes nicknamed "moon face" --- not a big deal, fellows, but something to mention. I will also say that my cheeks got a lot smoother --- I shaved every morning, because that's my habit, but your whiskers might really thin out, too, while you are doing chemo treatments. This is normal. Some of my friends who have recently gone through chemo were actually thankful that they could SKIP shaving, at times !
13. NEUROPATHY PREVENTION: Also --- my oncologist used this strategy and I have heard that more and more oncologists are now following this idea --- I was a bit incredulous at first, but now it is becoming more mainstream in its implementation among many doctors who oversee chemotherapy treatments. Other fellows here have now followed the same protocol. Here's how it worked in my case ... during infusions, they had me take off my shoes and I kept my socks ON --- then they put ice bags at my feet and told me to keep my feet on the ice bags during the infusions to prevent neuropathy --- they also placed ice bags on a pillow on my lap and told me to rest my fingers on ice bags to prevent neuropathy in my fingertips, which I did. I did this for EVERY chemo infusion session and had NO problems with neuropathy at all. My oncologist swore by this "ice bag method" method and so did my chemo nurses. So --- be PROACTIVE in advance and ASK for ice chips to chew on during the infusion process, to prevent loss of taste buds --- but also ASK your doctor about possibly using ice packs for your hands and feet to help PREVENT neuropathy damage in your fingertips and toes. Other fellows here have since affirmed that their doctors implemented this same method and reported positive results. PLEASE ask your doctor about this strategy, fellows ! Can't hurt and certainly MIGHT HELP !
14. HOT FLASHES & NIGHT SWEATS: Commonly, fellows who are starting chemo treatments are ALSO still taking ADT hormone shots to help control their P.S.A. levels. If you are taking ADT hormone shots and then begin chemo treatments, this COMBINATION of treatments is called "chemo-hormonal therapy" by doctors. Many men who are taking ADT hormone shots experience hot flashes throughout the day and/or nights sweats during the night. Some simple strategies for coping with these sudden and unexpected fluctuations in temperature that I have discovered over time include using room fans or ceiling fans to keep yourself cool and comfortable ... keeping glasses of ice water nearby throughout the day and on your nightstand by your bed ... wearing a lightweight cotton athletic shirt, with a button-down Oxford-style shirt over that, so that you can roll up the sleeves and adjust the buttons as necessary ... use cool cotton sheets and pillowcases for your bed, and you can double-sack your pillows to protect the pillows if you experience night sweats ... and some fellows use ice "gel packs" to apply to their forehead when a hot flash occurs. These are just some simple suggestions that I have gleaned over time if hot flashes or night sweats occur.
15. CHEMO BRAIN PHENOMENON: During the months of chemo treatments, I did feel that it was a bit harder to concentrate for longer periods of time. I functioned well at work throughout the day, but suddenly didn't feel that I could focus as well on a long chapter book or a long movie at night. Some chemotherapy patients describe it as "brain fog" or "chemo brain" and I think there is something to that. So, I contented myself with reading the newspaper, watching the news, and shorter television shows. Many fellows going through chemo feel that it's just harder to concentrate, to some extent. A common phenomenon experienced by many fellows who have undergone chemo treatments ! So --- if you find your attention span drifting a bit or find yourself forgetting a few things, now and then ... you can blame it all on what we have nicknamed CHEMO BRAIN ...
Again, while going through a series of chemotherapy treatments ... do EVERYTHING you can to stay interested in your family, friends, your usual activities, hobbies, and the world around you. Chemo is a CHAPTER in your life story --- don't let it become the TITLE of your BOOK OF LIFE. Keep living life as you go through the treatments, to the fullest extent possible !
I hope my list has given you some "real life" insight into my experiences with chemotherapy. These are the things that I learned from my experiences while going through TAXOTERE chemotherapy infusion treatments. These are some things that the standard chemo brochure from the doctor's office won't necessarily mention !
In all honesty, I felt I navigated through the entire series of chemotherapy treatments with side effects that were relatively MILD and very TOLERABLE ! I hope the things I have shared give you true-life insight and some things to consider. Each fellow has their own personal experience with chemo treatments. As I see all the responses being added to this thread, I feel that this thread is becoming very informative, with experiences gathered from a wide range of fellows who are now members of THE CHEMO CLUB.
"
Wow, I wish we could save your post on chemo, and managing side effects with a lnk to it, It is very comprehensive, Thank You
You're very welcome. Maybe I should post it under a new heading, hopefully making it easier to find in the search bar.
I do think that would be a good idea, I know I have saved it to my ipad.
This article is very helpful. I plan on making my own notes and going thru them with my doctor before I start my chemo in 2 weeks. Thank you so much TNCanuck
With all the research I’ve done taxotere is definitely not the end of the line in treatment. My husband just finished 3rd cycle of docetaxel and was scheduled for the fourth this week. Ct scans and bone scans last week showed enormous progression of the disease and psa jumped to 1900 - up 300 in just 3 weeks. Docetaxel is not working! We are now scheduled to start cabazitaxel next week. Still on Eligard. Just praying we see some slowing in disease progression. It is a beast! When cabazitaxel stops working we’ll be on to LU-177 or possibly other drug trials available in Canada.
Bob I had 6 rounds of taxotere, the chemo didn’t hurt that much but the gave me a followup shoot of Neulasta the next day for the bones that one put me down for a day or two. Just be ready for lots of rest and changes in your routine. Fight the good Fight
I went through 6 cycles of Taxotere with minimal side effects. Hair loss after 17 days, no nausea. And 1 day of fatigue on the 3rd day after my infusion. I did also gain some weight 15lbs. Overall it knocked my PSA to near 0.1. But now 2 years later I’m seeing my PSA triple every month so going for LU177 trial.
Stay strong and beat the beast back.
UCLA?
No I go to the Mayo Clinic in Rochester Mn
I had 10 cycles at 2 week intervals of Taxotere treatment recently and I agree that the post by TNCanuk is excellent advise. The side effects are well known and the treatments are easily taken. Stock up on the simple over the counter medicines and have them to hand if required. The use of Dexamethasone should keep the first few days after infusion easier to handle. I found exercising helped me. Good luck.
Hey truckerbob! Just saw your post from one month ago. How are now ?
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