Dx advanced PCa in 12, 2016 at age 66. Gleason 4+4=8, PSA high was 20, one suspected met at hip. No other involvement beyond suspected perineural. 37 RT sessions and LD brachy mid 2017, at Dattoli Cancer Center (where Dr. Snuffy Myers was treated) 10 additional RT sessions to pelvic lymph nodes there early 2018. I've been on LHRH shots (Luporon, Zolodex, now Trelstar) for 18 months, and Casodex & Avodart for the last 12 months, due to look at stopping ADT around December 2018. MRI, CT and bone scans in October 2017 were clear. PSA and testosterone continue to be at or below measurable levels. I have all the usual ADT SEs, and at this point, the cognitive, depression and fatigue issues are becoming increasingly debilitating, to the point that I am reluctant to make work or social commitments because can't predict how I will be. I was advised by the clinic to take Creatine 800mg twice a day, stay with the heart healthy diet and supplements, and to do as much vigorous exercise as I can manage. These have had some positive effects, but they are as random as the symptom manifestations. Does anyone have any suggestions beyond what I'm already doing? I'm pretty much at my wits' end, as I know many others are.