Moespy4 years ago

Also, Thanks to Tall_Allen for current and past posts/recommendations for my possible treatment path. Much appreciated!

dac5004 years ago

Your result is very similar to mine, except that I had about 10 lymph nodes lighting up. I had brachytherapy in 2011 and extra-capsular recurrence in 2016 treated with cyber knife and ADT. With a PSADT less than two months, I am now under ADT2 (Casodex and Lupron) treatment at Penn Medicine.

Moespy in reply to dac5004 years ago

Were you able to test the LN's?

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dac500 in reply to Moespy4 years ago

Yes I had biopsy of one of the lymph nodes that tested positive for metastatic prostate cancer.

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kmack574 years ago

Looks like you finally found the source of your PSA, the good news is that you still have curative options. I wish you the best with whatever treatment you choose and will pray for a full cure!

GeorgeGlass in reply to kmack572 years ago

This is where I get confused. If this is true then why do many of the doctors say that radiation would just attack the tip of the iceberg and the cancer is probably throughout the lymphatic system in microscopic levels?

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Moespy4 years ago

Thanks Kevin! Hoping for your PSA to drop to 0!

Ahk1 in reply to Moespy4 years ago

I have similar stats like yours but no psma test, my psa is .44 after failing surgery and IMRT. I am thinking of following the same path as yours. Please update us on your progress. Thanks

Happy new year

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Moespy in reply to Ahk14 years ago

Thanks Ahk1. The only thing I would maybe do differently is add ADT to the IMRT radiation on my first recurrence after surgery. I will update once next treatment path is chosen. I will discuss this my RO and my MO and together with the invaluable info learned on this forum will make the decision.

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Ahk1 in reply to Moespy4 years ago

Thanks mospy,

I made the same mistake by not including adt in the IMRT. The doctor didn’t tell me I need it and I didn’t know and when I asked why, it only adds 10% to success rate.

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Portugal-2 in reply to Ahk14 years ago

Hi My RO said exactly the same thing. I was told to still do the axium by urologist. They both said the G8 PSMA is not accurate and waiting for the rest and not doing salvage radiation would be a mistake. Doctors both think the jury is out on how effective adding ADT to your radiation makes that much of a difference. Plus the hormone may be needed later. My head is spinning . I am rescheduling and getting the axium test done. U of P is not recruiting yet and still trying to get an answer from NIH to get whatever I need to be on waiting list. Again both my urologist and RO said the same thing as TA, waiting for these tests may make it incurable period. So much appreciation to TA, he was right on the money. RO is not agreeing about whole pelvic area. So is doing the lower bed only and then watching PSA again. Can you then do radiation again?? Sorry if this is a stupid question but I don’t know and grateful for all the knowledge here!!

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Ahk1 in reply to Portugal-24 years ago

I am not really sure about doing the radiation again later. I am not experiencing in this sort of thing. I did the prostate bed only and it failed. I have not done the pet scans yet to see if nodes has cancer, so I didn’t investigate this approach but if I remember correctly that TA on another forum had told me it can be done but I am not totally sure.

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GeorgeGlass in reply to Moespy2 years ago

Have you heard from many guys who have already done this type of salvage radiation or adjuvant radiation and whether they recommend it or not based on their longer term outcomes?

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GP244 years ago

Radiating this met may be difficult since you already had IMRT radiation. Also, after the planned radiation new mets could show up at different places, which I consider very likely. With a PSADT of 10 months and just one met, you could safely just observe this for several years without any side effects.

Your situation is discussed in detail here:

europeanurology.com/article...

Citation: "More than half of nodal recurrences are located outside the true pelvis."

Ahk1 in reply to GP244 years ago

He only had radiation to prostate bed. I am in the same situation and thinking of taking the same path if the psma found any node Mets. Is approach wrong?

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Moespy4 years ago

GP24, Thanks very much for the info (link).

The IMRT I received did not include LN's so I think we can radiate the affected node.

I believe my RO at Hopkins will agree with the preferred path forward being observation versus radiation for the QOL off of ADT.

GeorgeGlass in reply to Moespy2 years ago

I notice this post was 2 years ago. What did you end up doing and how did it go?

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Moespy in reply to GeorgeGlass2 years ago

I had the LN biopsied and it was positive for PCa. I had the entire Pelvic LN area radiated with extra radiation to the affected nodes. I immediately started Lupron and my PSA has been undetectable since then. I am happy with the result.

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GP244 years ago

If you are determined to get that met radiated I recommend to radiate all the lymph nodes in the pelvis. See this study:

ro-journal.biomedcentral.co...

I decided against that since I considered the benefit to be too small for six weeks of radiation and its possible side effects. Plus I was asked to have adjuvant ADT with it.

Moespy in reply to GP244 years ago

Agree with radiating all pelvic LN's and have been advised to go with adjuvant ADT (2 months prior to radiation and 2 years after). If you don't mind me asking, how long ago did you receive the PSMA and where are you now in your treatment? Thanks again.

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GP24 in reply to Moespy4 years ago

"did you receive the PSMA?" I am not sure what you mean by that. My last PSMA PET/CT I got four weeks ago. As far as I am aware I have five, maybe seven lymph node mets in the pelvis now.

As you may have read, I wanted to treat these with a PSMA treatment. I did not get that yet, this is now scheduled for next year.

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Moespy in reply to GP244 years ago

I meant how long ago did you receive the PSMA scan, I did not realize you have received more than one. What is PSMAtreatment entail?

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GP24 in reply to Moespy4 years ago

Maybe you get a first impression from this article:

targetedonc.com/news/novel-...

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Moespy in reply to GP244 years ago

I understand now, I did not know you were MCRP. Thank you very much for the education. Jim

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GeorgeGlass in reply to GP242 years ago

What did you end up doing and how did it turn out for you GP? I'm thinking about getting a PSMA PET soon and possibly get lymph node(s) radiated in my pelvis but I dont know if it usually helps extend lifespan and if the lifespan addition length outweighs the likely side effects from the radiation.?

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Moespy in reply to GeorgeGlass2 years ago

Hi GeorgeGlass, The theory is the PSMA full-body scan identifies the visible PCa, which is then treated and followed by a 2-year stint on Lupron which starves the circulating micro mets to their death. So far so good for me as my PSA is still undetectable. No effects from the radiation and I have no doubt that it has increased my survival by putting off the use of further therapies if the PCa returns. Radiation is a safe and effective therapy these days if in the hands of a competent and experienced radiation oncologist. Best wishes.

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GP24 in reply to GeorgeGlass2 years ago

I described how this turned out in this post:

healthunlocked.com/advanced...

There have been no trials to determine whether removing the mets extends survival. I just prefer to have no mets and not get ADT with its side effects just to stop them from growing until I become castration-resistant. Spot radiation of mets with SBRT usually causes no side effects.

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Moespy4 years ago

Agree with radiating all pelvic LN's and have been advised to go with adjuvant ADT (2 months prior to radiation and 2 years after). If you don't mind me asking, how long ago did you receive the PSMA and where are you now in your treatment? Thanks again.

Ahk14 years ago

Moespy,

Are you doing the node biopsy at NIH or John’s Hopkins please?

Moespy4 years ago

NIH. Part of the trial is to sign a consent to have them do the biopsy if you wish. I sent you a message regarding my experience getting into the trial.

Break604 years ago

Read my profile and you’ll see that we have quite similar path but my recurrence was sooner due to poor pathology post RP at Johns Hopkins due presumably to Gleason 9 PCa. Doing all pelvic lymph nodes is important.

Good luck.

Moespy in reply to Break604 years ago

Thank you Brother!

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GeorgeGlass in reply to Break602 years ago

Break, do you end up radiating all the pelvic lymph nodes? Does that extend lifespan? How bad are the side effects on average?

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