I have read at least 3 times (I think) on this website that some claim that Docetaxel has been known to help with a successful re challenge with Zytiga. But I haven't been able to find anything in the literature that provides any information about this at all. Can anyone provide a reference for me on this topic? Zytiga worked 2 years for me very successfully, lowering my PSA considerably until it finally stopped working. I also had minimal side effects (in fact, none of which I was aware) with Zytiga. Since then I have had 6 doses of Docetaxel -- one every 3 weeks -- my last treatment was this last week. My PSA stayed about the same on Docetaxel. I certainly would be interested in trying Zytiga again (and talking to my oncologist about it) if there is evidence that Zytiga might be effective again after Docetaxel chemo treatment.