Long-term remission of prostate cancer with extensive bone metastases upon immuno- and virotherapy: A case report

[JLS1]

researchgate.net/publicatio...

Long‑term remission of prostate cancer with extensive bone

metastases upon immuno‑ and virotherapy: A case report

VOLKER SCHIRRMACHER1,2, AKOS-SIGMUND BIHARI1, WILFRIED STÜCKER1 and TOBIAS SPRENGER1

Immunological and Oncological Center, Cologne; 2German Cancer Research Center,

Division of Translational Immunology, Heidelberg, Germany

Received February 19, 2014; Accepted August 7, 2014

DOI: 10.3892/ol.2014.2588

Abstract.

The present study reports the case of a patient

with hormone-refractory metastatic prostate cancer who had

failed standard therapy, but then achieved complete remis-

sion following combined treatment with local hyperthermia

(LHT), Newcastle disease virus and dendritic cell (DC) vacci-

nation, which was an unusual combination. In August 2005,

the patient underwent a radical prostatectomy. Despite

standard treatment, the patient developed progressive bone

metastases and stopped conventional therapy in June 2007.

Starting in October 2007, the patient was treated with LHT,

oncolytic virotherapy and DC vaccination. Prostate‑specic

antigen (PSA)-levels, with the highest level of 233.8 ng/ml in

January 2008, decreased to 0.8 ng/ml in late February 2008.

In March 2008, a reduction in bone metastases could be

detected by positron emission tomography/computed tomog-

raphy. Since then, the PSA levels have remained low and the

patient is doing well. The treatment induced a long-lasting

antitumor memory T-cell response. This possibly explains the

long-term effectiveness of this novel experimental combined

treatment approach.

Introduction

Prostate cancer is the most common malignant tumor in

males (1). Conventional treatment, including surgery and

radiotherapy, has potential secondary effects, such as

impotence or incontinence, that can greatly impair quality

of life. By contrast, specic immunotherapy has no severe

side-effects, as it affects only the malignant cells and spares

the healthy tissue. Dendritic cell (DC) vaccination is an

important immunotherapeutic strategy. Oncolytic viro-

therapy and hyperthermia can have synergistic functions

with immunotherapy (2).

The approval of the rst therapeutic anticancer vaccine,

sipuleucel-T, by the Food and Drug Administration for the

treatment of metastatic hormone-refractory prostate cancer in

April 2010 has enforced a new era of immunotherapy (3). In a

phase III trial, following vaccination with activated autologous

DC, a prolonged overall survival time was demonstrated in

patients suffering from castration-resistant prostate cancer (4).

In addition, a number of other clinical trials have reported the

clinical benet of DC vaccination (5).

Another promising approach is the use of oncolytic viruses

that preferentially infect tumor cells. Newcastle disease virus

(NDV) is an avian RNA paramyxovirus with a high safety

prole in cancer patients. The three properties that make NDV

suited for ghting human cancer are its tumor-selective repli-

cation, antitumor cytotoxicity and immunostimulation (6).

Hyperthermia has been used for the treatment of a diverse

range of solid tumors. Various techniques for the application

of heat have been developed. The cellular effects that have

been described include the induction of apoptosis and the

expression of heat shock proteins (HSPs) (7). Also, synergistic

effects of hyperthermia in combination with chemotherapy

and irradiation have been observed (8). The present study

reports the effects of combining hyperthermia with oncolytic

virotherapy and DC-based immunotherapy

use the link above to continue read the case report and the entire article

[tango65]

Very interesting. Thanks for posting it.

[Canoehead]

Wow. Single case, but promising. Everyone realizes that ADT and related treatments are for the most part a stop gap, albeit a very long one for some. The future and the “cure” seem to be in immunology. If I ever need a third opinion, i’m going to Cologne. I speak passable German and like beer, so I will think of it as a vacation.

[FISHLAND]

Its like a dream....10 years ago... what thinking about this. They didn't continue the treatment why?

[j-o-h-n]

FYI

Immunotherapy for my stage IV lung melanoma.

After 16 Treatments of Keytruda starting 02/07/2017 and last treatment on 1/10/2008 my tumor shrunk from 2.4 x 2.2 cm. to a decreased residual ill-defined left lower lobe metastasis, barely perceptible.

I met with Dr and based upon my CT Scan of 01/26/2018 he said that I do not need any more treatments (if any) for 3 months. Each treatment is $30K

Good Luck and Good Health.

j-o-h-n Thursday 03/08/2018 5:41 PM EST

[FISHLAND]

Bonjour John what kind of immunotherapy did you get?

[andrew61]

More info...

health24.com/Medical/Prosta...

[JLS1]

This sounds VERY promising! The article is dated Feb 14, 2018, so I wonder how much progress they've made since then towards beginning human clinical trials.